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Chagas' disease: virulence factor identified

ion of Tc52's enzyme activity by anti-parasitic drugs or vaccines, against T. cruzi. Research projects are currently planned in conjunction with other institutes (3) with the objective of molecular characterization of particular receptors of this protein situated on the macrophages and the dendritic cells, and of devising specific inhibitors. In this way they will contribute to formulation of the tools necessary for drug development.

(1) UR 008 Pathognie des Trypanosomatidae of the IRD
(2) thioltransferase, involved in the parasite's protection against oxidation stress.
(3) CNRS Laboratoire d'immunologie et chimie thrapeutique (UPR 9021) at Strasbourg and INSERM joint research unit (UMR) 564 of Angers Faculty of Medicine.


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Contact: Bndicte Robert
presse@paris.ird.fr
33-1-48-03-75-19
Institut de Recherche Pour le Dveloppement
6-Jan-2004


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