HOME >> MEDICINE >> NEWS
Changing chemistry helps explain estrogen threat to the heart

A piece of the topical puzzle of how estrogen goes from protecting women from heart disease to apparently increasing their risk later in life may have been found.

Medical College of Georgia researchers have found changes in blood vessel chemistry that may explain the dramatic flip-flop in estrogen's function that occurs in older women, taking it from a dilator of vessels to a potentially dangerous constrictor, says Dr. Richard White, MCG pharmacologist.

Dr. White will present the findings at the American Heart Association's Second International Conference on Women, Heart Disease and Stroke in Orlando, Fla., Feb. 16-19.

He hopes the findings will ultimately make hormone replacement therapy safer, possibly by adding to the mix compounds that enable estrogen's protective role before menopause.

Hormone replacement therapy, touted for its ability to reduce the risk of heart attack and stroke in postmenopausal women, appears to increase the risk of those conditions, according to findings of the Women's Health Initiative, a 15-year study of more than 161,000 women by the National Institute of Health's National Heart, Lung and Blood Institute.

This bad news about estrogen and the heart puzzled Drs. White and Scott A. Barman, also an MCG pharmacologist, as much as it did many physicians who had long prescribed it.

They were studying estrogen's effects on blood vessels, focusing on its impact on the smooth muscle cells that allow blood vessels to contract, thereby regulating blood pressure and blood flow. These researchers found that estrogen targets nitric oxide synthase 1, one of three versions of the enzyme that makes the powerful vasodilator, nitric oxide.

"What we were finding is that estrogen seems to be what you might call a natural nitroglycerin; nitroglycerin also works by making nitric oxide," Dr. White says.

Then they tried to block estrogen's activity by blocking nitric oxide. "What surprised the
'"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
16-Feb-2005


Page: 1 2 3

Related medicine news :

1. Changing trends in herbal supplement use
2. The Larry King Cardiac Foundation presents The Changing Face of Heart Disease on Feb. 2
3. Changing the timing of cancer vaccines
4. Changing prescribing behaviour through the mail
5. Changing partner increases risk of preterm birth
6. Changing Life, Challenging Cancer conference
7. Changing approaches to treating gum disease
8. Changing Drug Delivery For Rheumatoid Arthritis Patients Increases Effectiveness, Lowers Costs
9. NJIT chemistry professor edits text outlining best laboratory practices
10. Sealing corneal incisions with a drop of chemistry, BU researchers develop gel for cataract surgery
11. Herbal supplements testing topic of discussion at chemistry meeting March 30

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Changing chemistry helps explain estrogen threat the heart

(Date:8/31/2015)... ... ... MeYou Health ®, a social well-being company and wholly owned subsidiary of Healthways, ... in-app step tracker. , Walkadoo is a pedometer-based walking program that provides ... every Walkadoo member 10,000 steps a day (as is typical for many walking programs), ...
(Date:8/31/2015)... ... August 31, 2015 , ... There’s big news for ... digital healthcare industry. , Consumer driven health plans (CDHPs) are a growing phenomenon, ... and strategic role to the company, and another to answer customers’ questions directly. , ...
(Date:8/31/2015)... ... August 31, 2015 , ... The Brooks Group, a ... , a department devoted to helping organizations identify and keep the best talent ... and The Brooks Group believes in offering a solution that goes beyond simply ...
(Date:8/31/2015)... ... ... Now here’s some good health news: Nearly two-thirds of Americans say they ... with the majority of Americans eating more whole grains than they did five years ... findings and others from the 2015 Whole Grains Consumer Insights Survey in time for ...
(Date:8/31/2015)... ... August 31, 2015 , ... Now through October 31st, ... will be featured on a digital screen projected above New York’s Times Square, ... and promote earlier awareness of the symptoms of ovarian cancer, and earlier conversations ...
Breaking Medicine News(10 mins):Health News:Walkadoo™ Walking Program Now Includes In-app Step Tracker 2Health News:ZendyHealth Adds Two Prestigious Consumer Driven Health Plan (CDHP) Experts 2Health News:ZendyHealth Adds Two Prestigious Consumer Driven Health Plan (CDHP) Experts 3Health News:The Brooks Group Introduces Talent Management Division 2Health News:The Brooks Group Introduces Talent Management Division 3Health News:Most Americans Now Make Half Their Grains Whole 2Health News:Most Americans Now Make Half Their Grains Whole 3Health News:Most Americans Now Make Half Their Grains Whole 4Health News:Most Americans Now Make Half Their Grains Whole 5Health News:National Ovarian Cancer Coalition Rolls Out "TAKE ACTION. NOT CHANCES. (SM)" Campaign for September, National Ovarian Cancer Awareness Month 2Health News:National Ovarian Cancer Coalition Rolls Out "TAKE ACTION. NOT CHANCES. (SM)" Campaign for September, National Ovarian Cancer Awareness Month 3
(Date:8/28/2015)... Aug. 28, 2015 ... the addition of the "Investigation Report on ... offering. Developed by Pharmacia & Upjohn ... agonist which effectively reduces intraocular pressure. As the ... (under the trade name of Xalatan) entered ...
(Date:8/28/2015)... The scientific team of a new biotech company ... academics in the field of aging Prof. Robert J. ... for model animals - 10 fold for nematodes) has recently ... primarily, around the stability and stress resistance of certain gene ... analysis of a model gene network links aging, stress resistance, ...
(Date:8/28/2015)... , Aug. 28, 2015 Perrigo Company plc ... the Mylan N.V. ("Mylan") (NASDAQ: MYL ) shareholder ... "Our views of Mylan,s offer to Perrigo ... based on our Board,s careful reflection of the value ... the limited choices that Mylan has allowed its shareholders ...
Breaking Medicine Technology:China Latanoprost Market Investigation Report 2015-2019 2Gero: Physics Meets Biology to Help Defeat Aging 2Gero: Physics Meets Biology to Help Defeat Aging 3Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 2Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 3Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 4Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 5
Cached News: