HOME >> MEDICINE >> NEWS
Changing chemistry helps explain estrogen threat to the heart

A piece of the topical puzzle of how estrogen goes from protecting women from heart disease to apparently increasing their risk later in life may have been found.

Medical College of Georgia researchers have found changes in blood vessel chemistry that may explain the dramatic flip-flop in estrogen's function that occurs in older women, taking it from a dilator of vessels to a potentially dangerous constrictor, says Dr. Richard White, MCG pharmacologist.

Dr. White will present the findings at the American Heart Association's Second International Conference on Women, Heart Disease and Stroke in Orlando, Fla., Feb. 16-19.

He hopes the findings will ultimately make hormone replacement therapy safer, possibly by adding to the mix compounds that enable estrogen's protective role before menopause.

Hormone replacement therapy, touted for its ability to reduce the risk of heart attack and stroke in postmenopausal women, appears to increase the risk of those conditions, according to findings of the Women's Health Initiative, a 15-year study of more than 161,000 women by the National Institute of Health's National Heart, Lung and Blood Institute.

This bad news about estrogen and the heart puzzled Drs. White and Scott A. Barman, also an MCG pharmacologist, as much as it did many physicians who had long prescribed it.

They were studying estrogen's effects on blood vessels, focusing on its impact on the smooth muscle cells that allow blood vessels to contract, thereby regulating blood pressure and blood flow. These researchers found that estrogen targets nitric oxide synthase 1, one of three versions of the enzyme that makes the powerful vasodilator, nitric oxide.

"What we were finding is that estrogen seems to be what you might call a natural nitroglycerin; nitroglycerin also works by making nitric oxide," Dr. White says.

Then they tried to block estrogen's activity by blocking nitric oxide. "What surprised the
'"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
16-Feb-2005


Page: 1 2 3

Related medicine news :

1. Changing trends in herbal supplement use
2. The Larry King Cardiac Foundation presents The Changing Face of Heart Disease on Feb. 2
3. Changing the timing of cancer vaccines
4. Changing prescribing behaviour through the mail
5. Changing partner increases risk of preterm birth
6. Changing Life, Challenging Cancer conference
7. Changing approaches to treating gum disease
8. Changing Drug Delivery For Rheumatoid Arthritis Patients Increases Effectiveness, Lowers Costs
9. NJIT chemistry professor edits text outlining best laboratory practices
10. Sealing corneal incisions with a drop of chemistry, BU researchers develop gel for cataract surgery
11. Herbal supplements testing topic of discussion at chemistry meeting March 30

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2017)... ... , ... “THE FLINTHILLS FAMILY-Our Journey to the Cross”: the personal journey of Bob Massey and ... creation of published authors, Bob and Margaret Massey. Bob Massey is small in stature ... and leather tough." His love for others is apparent in all of his life ...
(Date:5/26/2017)... ... ... the Garden of Eden”: retells the stories of three Bible figures in modern terms. ... Colt, mother, trader, horse farmer, artist and a former GM journeyman. Born in 1953 ... they moved to Dayton, Ohio, where Penny graduated high school. At sixteen, she toured ...
(Date:5/26/2017)... ... 2017 , ... Water damage to the flooring of several classrooms at The ... officials with a number of critical issues to address before students could return to ... with little or no disruption to class schedules. Second, the project had to comply ...
(Date:5/24/2017)... , ... May 24, 2017 , ... ... background. Understanind and choosing the most appropriate instruments for research and understanding the ... research finding. This webinar will focus on innovations in stereo microscopy for brightfield ...
(Date:5/24/2017)... ... May 24, 2017 , ... Altec Products, Inc., a ... 2017 – a one-day technology conference in San Diego, CA. , At nVerge ... users to fully utilize and enhance their Sage ERP solutions by providing improved visibility ...
Breaking Medicine News(10 mins):
(Date:5/15/2017)... May 15, 2017  Amy Baxter MD, chief executive ... in noninvasive pain relief, was awarded a 2017 Top ... Baxter was recognized at the MM&M Top 40 Healthcare ... City on May 10, 2017. The dinner ... industry go "beyond the pill."  "Innovation goes ...
(Date:5/11/2017)... -- Thornhill Research Inc. ( Toronto, Ontario, Canada ... five-year, firm-fixed-priced, indefinite-quantity/indefinite-delivery contract by the U.S. Department ... ( Ottawa, Ontario, Canada ) to ... to patients requiring emergency medical procedures in a ... have been a longtime partner with Thornhill Research ...
(Date:5/10/2017)... -- The Corporate Whistleblower Center says, "We are urging ... to call us anytime at 866-714-6466 if they possess ... a substantial scheme to overbill Medicare. We are ... of a medical equipment company if their employer ... practice groups with extra generous incentives to use, or ...
Breaking Medicine Technology:
Cached News: