HOME >> MEDICINE >> NEWS
Changing chemistry helps explain estrogen threat to the heart

A piece of the topical puzzle of how estrogen goes from protecting women from heart disease to apparently increasing their risk later in life may have been found.

Medical College of Georgia researchers have found changes in blood vessel chemistry that may explain the dramatic flip-flop in estrogen's function that occurs in older women, taking it from a dilator of vessels to a potentially dangerous constrictor, says Dr. Richard White, MCG pharmacologist.

Dr. White will present the findings at the American Heart Association's Second International Conference on Women, Heart Disease and Stroke in Orlando, Fla., Feb. 16-19.

He hopes the findings will ultimately make hormone replacement therapy safer, possibly by adding to the mix compounds that enable estrogen's protective role before menopause.

Hormone replacement therapy, touted for its ability to reduce the risk of heart attack and stroke in postmenopausal women, appears to increase the risk of those conditions, according to findings of the Women's Health Initiative, a 15-year study of more than 161,000 women by the National Institute of Health's National Heart, Lung and Blood Institute.

This bad news about estrogen and the heart puzzled Drs. White and Scott A. Barman, also an MCG pharmacologist, as much as it did many physicians who had long prescribed it.

They were studying estrogen's effects on blood vessels, focusing on its impact on the smooth muscle cells that allow blood vessels to contract, thereby regulating blood pressure and blood flow. These researchers found that estrogen targets nitric oxide synthase 1, one of three versions of the enzyme that makes the powerful vasodilator, nitric oxide.

"What we were finding is that estrogen seems to be what you might call a natural nitroglycerin; nitroglycerin also works by making nitric oxide," Dr. White says.

Then they tried to block estrogen's activity by blocking nitric oxide. "What surprised the
'"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
16-Feb-2005


Page: 1 2 3

Related medicine news :

1. Changing trends in herbal supplement use
2. The Larry King Cardiac Foundation presents The Changing Face of Heart Disease on Feb. 2
3. Changing the timing of cancer vaccines
4. Changing prescribing behaviour through the mail
5. Changing partner increases risk of preterm birth
6. Changing Life, Challenging Cancer conference
7. Changing approaches to treating gum disease
8. Changing Drug Delivery For Rheumatoid Arthritis Patients Increases Effectiveness, Lowers Costs
9. NJIT chemistry professor edits text outlining best laboratory practices
10. Sealing corneal incisions with a drop of chemistry, BU researchers develop gel for cataract surgery
11. Herbal supplements testing topic of discussion at chemistry meeting March 30

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... Petersburg, FL (PRWEB) , ... April 29, 2016 , ... ... look at products on the market. They recently reviewed the ZEN BOX , ... Typically there are two single essential oils (like lavender or frankincense) and one Zen ...
(Date:4/28/2016)... ... April 28, 2016 , ... Sanford Health’s work in ... group of researchers and leaders from Sanford Health were selected to participate in ... Cultural Impact ” and receive the 2016 Pontifical Key Innovation Award at the ...
(Date:4/28/2016)... , ... April 28, 2016 , ... ... is proud to partner with AquaShieldUSA, the country's oldest waterproof cast protector ... and medical supply stores, the largest selection of daily, night, weatherproof and waterproof ...
(Date:4/28/2016)... Austin, TX (PRWEB) , ... ... ... Data Interchange Standards Consortium (CDISC) announces today the open availability of a ... official platforms and catalogs for registering clinical trials. This innovative standard will ...
(Date:4/28/2016)... , ... April 28, 2016 , ... ... the Campaign for Tobacco-Free Kids, a leading force in the fight to reduce ... state and local policies that can help reduce tobacco use. The initiative brings ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... TOKYO , April 28, 2016 /PRNewswire/ ... Ahuja , George Phillips und ... wachsenden Unternehmens    ArisGlobal®, ein ... Life Sciences, gab heute bekannt, dass neue ... wachsenden Unternehmens gestoßen sind, die vielfältige Erfahrungen ...
(Date:4/28/2016)... YORK , April 28, 2016 ... online consumer insights on healthcare, announced today that it ... their report Cool Vendor in Life Sciences, 2016, ... April 15, 2016.  The report focuses on life-science- oriented ... gain insight from patients and doctors, confirm medication ingestion, ...
(Date:4/28/2016)... , April 28, 2016 Dr. ... and Ste phen ... ArisGlobal®, a leading provider of cloud-based software solutions for life sciences, ... team to bring a wealth of insight to a growing business. ... knowledge. George Phillips joined ArisGlobal in the ...
Breaking Medicine Technology:
Cached News: