HOME >> MEDICINE >> NEWS
Cholesterol-lowering drug may slow Alzheimer's progression

NEW ORLEANS, Nov. 9 The cholesterol-lowering drug atorvastatin slowed down mental decline and improved depressive symptoms in people with Alzheimer's disease, according to a small pilot study reported at the American Heart Association's Scientific Sessions 2004.

"This is the first off-label use of a drug tested in Alzheimer's patients in the last 10 years that has shown promise of benefit," said D. Larry Sparks, Ph.D., senior scientist and head of the Roberts Laboratory for Neurodegenerative Disease Research at Sun Health Research Institute in Sun City, Ariz.

Animal and human studies have shown that elevated cholesterol is an important risk factor for Alzheimer's disease. Based on this research and Sparks's work for the past 20 years, he and colleagues in Bethesda, Md., New York City, Phoenix and Sun City, tested the effects of lowering cholesterol in people with mild-to-moderate Alzheimer's disease.

The Alzheimer's Disease Cholesterol-Lowering Treatment Trial (ADCLT) was a double-blind, placebo-controlled pilot study that assessed whether lowering cholesterol with atorvastatin could stabilize or improve cognition in people with mild-to-moderate Alzheimer's. Doctors administered the statin drug in addition to the cholinesterase inhibitors the patients were already taking. Cholinesterase inhibitors are the only Food and Drug Administrationapproved therapy for mild-to-moderate Alzheimer's disease. The drugs inhibit the breakdown of acetylcholine, a transmitter that is decreased in Alzheimer's patients and thought to be related to mental decline.

The researchers evaluated 46 patients -- 25 on atorvastatin 80 mg and 21 on placebo -- for one year. The participants were, on average, 78-years-old with 14 years of education. One-third of the group was female. The patients were evaluated periodically for cognition, overall mental function and depression. Alzheimer's patients are known to have depression that usually gets worse as their Alzheimer
'"/>

Contact: Darcy Spitz
darcy.spitz@heart.org
212-878-5940
American Heart Association
9-Nov-2004


Page: 1 2 3

Related medicine news :

1. Cholesterol-lowering drug may also reduce risk of blood clots
2. Cholesterol-lowering medications may reduce risk of glaucoma
3. Cholesterol-lowering drugs may help stroke patients get well
4. Cholesterol-lowering drugs safe and effective in children
5. Cholesterol-lowering drugs should revolutionise treatment of heart attack and stroke
6. Cholesterol-lowering drugs provide double protection against heart disease
7. Chemical decoy shows promise for slowing Alzheimers by acting as decoy
8. Neuronal death and processing of Tau protein in Alzheimers disease
9. Researchers discover link between insulin and Alzheimers
10. New trials for counseling caregivers and patients with Alzheimers begin
11. Marijuana ingredient may stall decline from Alzheimers

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cholesterol lowering drug may slow Alzheimer progression

(Date:8/21/2014)... While golfing in Scotland and abroad, Biteback ... focused on his game due to the incessant buzzing ... and continual need to spray insect repellent became so ... from insects while golfing. He ultimately found a solution ... Banking Industry, decided to change direction and launch Biteback ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 Denver ... Inspirational Sponsor for the American Lung Association in Colorado’s ... thrilled to welcome Webolutions as a sponsor,” said Curt ... Southwest, and Executive Director, American Lung Association in Colorado, ... the table in this role they’ve defined.” , Webolutions ...
(Date:8/21/2014)... HIPAA Secure Now! rolled out its EHR (electronic ... vendors to now offer their customers a HIPAA security ... , HIPAA Secure Now! provides risk analysis services, ... U.S. The company assesses the risks of storing and ... and device used by the practice. , HIPAA ...
(Date:8/21/2014)... 2014 Consilium Staffing, Your Partner in ... temporary physicians in response to the President’s landmark VA ... billion to the Department of Veterans Affairs to hire ... more than one hundred fifty medical centers nationwide, and ... of patients awaiting treatment, including vets from the Vietnam ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 The employees ... Historic Park in Washington Crossing, Pennsylvania on Thursday, August ... park. “We have been looking for different ways that ... Matt Kiernan, Partner with Pharmica Consulting. “When we heard ... of U.S. history, we jumped at the opportunity.” , ...
Breaking Medicine News(10 mins):Health News:Financial VP Fights Pesky Bugs with Launch of Biteback Sports Insect Shield® Golf Apparel 2Health News:Denver Marketing Agency Webolutions Named Inspirational Sponsor for 2014 Run the ‘Rocks 5K 2Health News:Denver Marketing Agency Webolutions Named Inspirational Sponsor for 2014 Run the ‘Rocks 5K 3Health News:HIPAA Secure Now! Ramps up EHR Partner Program, Helps Healthcare Providers Achieve Meaningful Use under Revised CMS Deadlines 2Health News:Consilium Staffing Providing Locum Tenens in Response to VA Hospital Reform Legislation 2Health News:Pharmica Spends the Day Helping to Preserve Washington Crossing Historic Park 2
(Date:8/21/2014)... 2014   Royal Philips (NYSE: ... has received 510(k) clearance from the U.S. Food ... application for Transcatheter Aortic-Valve Implantation (TAVI) treatments. Through ... with pre-procedural, high-precision positioning to treat aortic stenosis ... is available as part of Philips IntelliSpace ...
(Date:8/21/2014)... CYBX ) today announced results for the quarter ...   Operating results for the first quarter of ... and other achievements, include: , Worldwide net product sales ... international net sales of $13.2 million, an increase of 14.5% ... sales reached a new high of $58.8 million, an increase ...
(Date:8/21/2014)... 2014  SI-BONE, Inc. ( San Jose, California ... use of the iFuse Implant System, ® a ... the sacroiliac (SI) joint, announced that Priority Health ( ... Lumbar Fusion Medical Policy No. 91590-R4 providing positive coverage ... states that the fusion procedure, which employs the iFuse ...
Breaking Medicine Technology:Philips receives FDA 510(k) Clearance for TAVI Precision Treatment Planning Application 2Philips receives FDA 510(k) Clearance for TAVI Precision Treatment Planning Application 3Cyberonics Reports Fiscal 2015 First Quarter Results 2Cyberonics Reports Fiscal 2015 First Quarter Results 3Cyberonics Reports Fiscal 2015 First Quarter Results 4Cyberonics Reports Fiscal 2015 First Quarter Results 5Cyberonics Reports Fiscal 2015 First Quarter Results 6Cyberonics Reports Fiscal 2015 First Quarter Results 7Cyberonics Reports Fiscal 2015 First Quarter Results 8Cyberonics Reports Fiscal 2015 First Quarter Results 9Cyberonics Reports Fiscal 2015 First Quarter Results 10Cyberonics Reports Fiscal 2015 First Quarter Results 11Cyberonics Reports Fiscal 2015 First Quarter Results 12Cyberonics Reports Fiscal 2015 First Quarter Results 13Cyberonics Reports Fiscal 2015 First Quarter Results 14Cyberonics Reports Fiscal 2015 First Quarter Results 15Cyberonics Reports Fiscal 2015 First Quarter Results 16SI-BONE, Inc. Announces Positive Coverage Decision by Priority Health 2SI-BONE, Inc. Announces Positive Coverage Decision by Priority Health 3
Cached News: