HOME >> MEDICINE >> NEWS
Cholesterol-lowering drug may slow Alzheimer's progression

NEW ORLEANS, Nov. 9 The cholesterol-lowering drug atorvastatin slowed down mental decline and improved depressive symptoms in people with Alzheimer's disease, according to a small pilot study reported at the American Heart Association's Scientific Sessions 2004.

"This is the first off-label use of a drug tested in Alzheimer's patients in the last 10 years that has shown promise of benefit," said D. Larry Sparks, Ph.D., senior scientist and head of the Roberts Laboratory for Neurodegenerative Disease Research at Sun Health Research Institute in Sun City, Ariz.

Animal and human studies have shown that elevated cholesterol is an important risk factor for Alzheimer's disease. Based on this research and Sparks's work for the past 20 years, he and colleagues in Bethesda, Md., New York City, Phoenix and Sun City, tested the effects of lowering cholesterol in people with mild-to-moderate Alzheimer's disease.

The Alzheimer's Disease Cholesterol-Lowering Treatment Trial (ADCLT) was a double-blind, placebo-controlled pilot study that assessed whether lowering cholesterol with atorvastatin could stabilize or improve cognition in people with mild-to-moderate Alzheimer's. Doctors administered the statin drug in addition to the cholinesterase inhibitors the patients were already taking. Cholinesterase inhibitors are the only Food and Drug Administrationapproved therapy for mild-to-moderate Alzheimer's disease. The drugs inhibit the breakdown of acetylcholine, a transmitter that is decreased in Alzheimer's patients and thought to be related to mental decline.

The researchers evaluated 46 patients -- 25 on atorvastatin 80 mg and 21 on placebo -- for one year. The participants were, on average, 78-years-old with 14 years of education. One-third of the group was female. The patients were evaluated periodically for cognition, overall mental function and depression. Alzheimer's patients are known to have depression that usually gets worse as their Alzheimer
'"/>

Contact: Darcy Spitz
darcy.spitz@heart.org
212-878-5940
American Heart Association
9-Nov-2004


Page: 1 2 3

Related medicine news :

1. Cholesterol-lowering drug may also reduce risk of blood clots
2. Cholesterol-lowering medications may reduce risk of glaucoma
3. Cholesterol-lowering drugs may help stroke patients get well
4. Cholesterol-lowering drugs safe and effective in children
5. Cholesterol-lowering drugs should revolutionise treatment of heart attack and stroke
6. Cholesterol-lowering drugs provide double protection against heart disease
7. Chemical decoy shows promise for slowing Alzheimers by acting as decoy
8. Neuronal death and processing of Tau protein in Alzheimers disease
9. Researchers discover link between insulin and Alzheimers
10. New trials for counseling caregivers and patients with Alzheimers begin
11. Marijuana ingredient may stall decline from Alzheimers

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cholesterol lowering drug may slow Alzheimer progression

(Date:4/27/2015)... Fitness expert Samir Becic, four-time No. 1 ... and fitness revolution, teaming up with several celebrities in ... years, Houston, the fourth largest city in America, has ... America. With help from his friends, Becic aims to ... fittest and healthiest cities in the nation. , Two-time ...
(Date:4/27/2015)... April 27, 2015 Based in the ... is one of the few insurance marketing organizations in ... income and asset protection markets as well as employer ... has afforded Secura Consultants the opportunity to consult with ... doing business easier and quicker. , An example of ...
(Date:4/27/2015)... April 27, 2015 On May 5, people ... ask their social media friends around the world to join ... asthma. , May 5 is World Pulmonary Hypertension Day ... leader in the global PH community, will take part in ... blood pressure of the lungs. PH is an increase in ...
(Date:4/27/2015)... April 27, 2015 On April 16, 2015, ... Get Rid of Stretch Marks ,” interviewed a UK dermatologist ... Stretch marks are a type of scar that ... caused by a breakdown of the elsastin and collagen in ... (see: goo.gl/iRdmEe) , “Stretch mark removal with the Coolbeam protocol ...
(Date:4/27/2015)... Santa Rosa, CA (PRWEB) April 27, 2015 ... uniformly and prevents unneeded risk of damaging hot spots. ... other grow tents because of their sturdy structure and ... This unique lining was design to effectively distribute lumens ... reflectivity allows the most benefit from grow lights and ...
Breaking Medicine News(10 mins):Health News:Houston Celebrities Take a Stand and Rebel Against Obesity 2Health News:Simplified Solutions Now Makes Disability Insurance Business With Secura Consultants Even Easier! 2Health News:Pulmonary Hypertension Association Marks World PH Day on May 5 with a Worldwide Lifesaving Social Media Blitz 2Health News:Pulmonary Hypertension Association Marks World PH Day on May 5 with a Worldwide Lifesaving Social Media Blitz 3Health News:Stretch Marks: The Latest Treatment Options for Stretch Mark Removal 2
(Date:4/27/2015)... , April 27, 2015 Numerous Zofran ... courts around the U.S. have highlighted serious concerns surrounding ... LLP reports. According to the U.S. Centers for ... currently on the market have enough information to determine ... of 10 expectant mothers in the U.S. take at ...
(Date:4/27/2015)... and WASHINGTON , April ... Pharmacy (NASP) and SmartBrief recently partnered to deliver a ... snapshot of the top news in the industry. The ... pharmaceutical and biotechnology manufacturers, GPOs, distributors and other specialty ... will launch on April 27, 2015. "We ...
(Date:4/27/2015)... 2015  Together with its parent partners and the ... an initiative of Morris County Prevention is Key (MCPIK), ... first-of-its-kind community effort to address the heroin/opiate crisis in ... Volunteer Parent Coaches from the ... Denise Mariano , National Council on Alcoholism and ...
Breaking Medicine Technology:Growing Zofran Birth Defects Litigation Highlights Concerns Surrounding Use of Prescription Medications During Pregnancy, According to Bernstein Liebhard LLP 2Growing Zofran Birth Defects Litigation Highlights Concerns Surrounding Use of Prescription Medications During Pregnancy, According to Bernstein Liebhard LLP 3NASP and SmartBrief Partner on Specialty Pharmacy SmartBrief 2Partnership for Drug-Free Kids Brings Life-Saving Kits and Training to New Jersey Families 2Partnership for Drug-Free Kids Brings Life-Saving Kits and Training to New Jersey Families 3
Cached News: