HOME >> MEDICINE >> NEWS
Cholesterol-lowering drug may slow Alzheimer's progression

NEW ORLEANS, Nov. 9 The cholesterol-lowering drug atorvastatin slowed down mental decline and improved depressive symptoms in people with Alzheimer's disease, according to a small pilot study reported at the American Heart Association's Scientific Sessions 2004.

"This is the first off-label use of a drug tested in Alzheimer's patients in the last 10 years that has shown promise of benefit," said D. Larry Sparks, Ph.D., senior scientist and head of the Roberts Laboratory for Neurodegenerative Disease Research at Sun Health Research Institute in Sun City, Ariz.

Animal and human studies have shown that elevated cholesterol is an important risk factor for Alzheimer's disease. Based on this research and Sparks's work for the past 20 years, he and colleagues in Bethesda, Md., New York City, Phoenix and Sun City, tested the effects of lowering cholesterol in people with mild-to-moderate Alzheimer's disease.

The Alzheimer's Disease Cholesterol-Lowering Treatment Trial (ADCLT) was a double-blind, placebo-controlled pilot study that assessed whether lowering cholesterol with atorvastatin could stabilize or improve cognition in people with mild-to-moderate Alzheimer's. Doctors administered the statin drug in addition to the cholinesterase inhibitors the patients were already taking. Cholinesterase inhibitors are the only Food and Drug Administrationapproved therapy for mild-to-moderate Alzheimer's disease. The drugs inhibit the breakdown of acetylcholine, a transmitter that is decreased in Alzheimer's patients and thought to be related to mental decline.

The researchers evaluated 46 patients -- 25 on atorvastatin 80 mg and 21 on placebo -- for one year. The participants were, on average, 78-years-old with 14 years of education. One-third of the group was female. The patients were evaluated periodically for cognition, overall mental function and depression. Alzheimer's patients are known to have depression that usually gets worse as their Alzheimer
'"/>

Contact: Darcy Spitz
darcy.spitz@heart.org
212-878-5940
American Heart Association
9-Nov-2004


Page: 1 2 3

Related medicine news :

1. Cholesterol-lowering drug may also reduce risk of blood clots
2. Cholesterol-lowering medications may reduce risk of glaucoma
3. Cholesterol-lowering drugs may help stroke patients get well
4. Cholesterol-lowering drugs safe and effective in children
5. Cholesterol-lowering drugs should revolutionise treatment of heart attack and stroke
6. Cholesterol-lowering drugs provide double protection against heart disease
7. Chemical decoy shows promise for slowing Alzheimers by acting as decoy
8. Neuronal death and processing of Tau protein in Alzheimers disease
9. Researchers discover link between insulin and Alzheimers
10. New trials for counseling caregivers and patients with Alzheimers begin
11. Marijuana ingredient may stall decline from Alzheimers

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cholesterol lowering drug may slow Alzheimer progression

(Date:8/1/2014)... FRIDAY, Aug. 1, 2014 (HealthDay News) -- Although older women ... make asthma care a priority, according to a new study. ... from asthma much more than men over 65," concluded Dr. ... of Allergy, Asthma and Immunology (ACAAI), in an organization news ... age 65 years and older is nearly four times higher ...
(Date:8/1/2014)... New research shows that people who grew up ... a 16-percent greater risk of experiencing poor health quality ... sent to prison. The finding, which accounted for other ... rate of imprisonment may be independently imparting enduring physical ... people were children when this happened, and it was ...
(Date:8/1/2014)... Pass, OR (PRWEB) August 01, 2014 ... also called hydrotherapy – was fundamental to the practice ... and water researcher Sharon Kleyne, water therapy has been ... a time when climate change, water shortages, drought and ... related diseases, the Sharon Kleyne Hour Power of Water ...
(Date:8/1/2014)... 01, 2014 Did you know that July ... Awareness Month is to raise awareness across the country and ... for, sarcoma. According to the American Cancer Society, nearly 5,000 ... while 12,000 new soft tissue sarcomas will be diagnosed. ... tumors as they are other kinds of cancer,” said Dr. ...
(Date:8/1/2014)... August 01, 2014 “When insulation goes ... your entire home.“ In a newly released article entitled, ... Insulation Needs To Be Replaced ,” Clean Crawls explains ... damp, or been infested by critters. , Get ... from Clean Crawls - http://www.cleancrawl.com/contact . , If ...
Breaking Medicine News(10 mins):Health News:Older Women With Asthma Face Worse Health Outcomes 2Health News:Jailed family member increases risks for kids' adult health 2Health News:Jailed family member increases risks for kids' adult health 3Health News:Water Researcher Advocates Reevaluation of 18th and 19th Century Water Therapy Movement 2Health News:Water Researcher Advocates Reevaluation of 18th and 19th Century Water Therapy Movement 3Health News:July Was Sarcoma Awareness Month! 2Health News:July Was Sarcoma Awareness Month! 3Health News:July Was Sarcoma Awareness Month! 4Health News:5 Signs That Insulation Should Be Replaced Detailed in a Newly Released Article By Clean Crawls 2
(Date:7/31/2014)... and LONDON , July 31, 2014 ... provider for the medical industries, announced today the incorporation of genae ... United Kingdom has one of the largest medical ... billion in 2012 and it is projected to increase by a ... 234 billion in 2012, equal to 9.5% of GDP. Despite recessionary ...
(Date:7/31/2014)... , July 31, 2014 Vermillion, Inc. (NASDAQ: ... women,s health, will hold a conference call on Thursday, August ... for the second quarter ended June 30, 2014. Financial results ... call. Vermillion,s Chairman, President and CEO James ... and answer period. Date: Thursday, August 14, 2014 ...
(Date:7/31/2014)... TB Alliance, a not-for-profit organization with the ... tuberculosis (TB), announced the appointment of Elana Robertson ... joins the organization from Novartis Vaccines, where she was ... Eastern Europe . In her new ... ensure beneficial new TB treatments are available and adopted ...
Breaking Medicine Technology:genae Opens Offices in London 2Vermillion Sets Second Quarter 2014 Conference Call for Thursday, August 14, 2014 2TB Alliance Names Elana Robertson Senior Vice President, Market Access 2TB Alliance Names Elana Robertson Senior Vice President, Market Access 3
Cached News: