Chronic fatigue syndrome and Gulf Wa...( Chronic Fatigue Syndrome (CFS) is nearl...),Health

Chronic Fatigue Syndrome (CFS) is nearly four times as common in veterans of the first Persian Gulf War as in nonveterans, according to a new study. The study, to be published May 14, 2004 in the online edition of Muscle & Nerve, examined the possibility that genetic factors may play a role in developing the disease. The full study will be available via Wiley InterScience at http://www3.interscience.wiley.com/cgi-bin/jissue/89014836.

Fatigue that has no known medical cause, lasts more than six months, produces a substantial decrease of activity and is accompanied by symptoms associated with infection, as well as rheumatological, and neuropsychiatric symptoms, is known as CFS; idiopathic chronic fatigue (ICF) is fatigue without other symptoms or identifiable cause. CFS/ICF sometimes occurs in an almost epidemic fashion, such as in Gulf War veterans, but its cause is unknown. Genetic factors appear to play a role in both Gulf War veterans and civilian populations. Partial defects in one or more genes combined with environmental factors can result in conditions that include fatigue as a prominent feature. Previous studies have shown that mutations in the myoadenylate deaminase gene (AMPD1) and the carnitine palmitoyltransferase II (CPT2) gene can produce pain, stiffness, cramps or fatigue following strenuous exercise, while a genetic variant known as the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme or ACE (DCP1) gene may impact performance and endurance in trained athletes and army recruits.

In this new study, Drs.Georgirene Vladutiu of the State University of New York at Buffalo and Benjamin Natelson of UMDNJ-New Jersey Medical School evaluated DNA from blood samples collected from 49 Gulf War veterans and 61 nonveterans with CFS/IFS and 30 veterans and 45 nonveterans who were healthy. Blood samples were analyzed for mutations in the AMPD1, DCP1, and
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Contact: David Greenberg
dgreenbe@wiley.com
201-748-6484
John Wiley & Sons, Inc.
14-May-2004

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