HOME >> MEDICINE >> NEWS
Coffee: a cause of neonatal seizures?

Epidemiological observations raised the possibility that coffee was deleterious for newborn babies. For the last ten years the American Food and Drug Administration (FDA) has therefore recommended that pregnant women limit their consumption of coffee.

The first underlying cerebral mechanisms have just been elucidated, by the use of a particular animal model, by INSERM unit 29.

The researchers based their investigations on two observations. First, caffeine contained in the coffee drunk by mothers crosses the fetal blood-brain barrier. On arriving in the brain, the caffeine binds specifically to neuronal adenosine receptors.

Second, fetal oxygenation frequently declines during delivery, especially when contractions last a few minutes, with a risk of hypoxia and severe complications.

It is these two phenomena (caffeine and oxygen starvation) that the researchers reproduced on neurons of the hippocampus, a particular brain structure that appears to be the site of memorization processes. In the presence of caffeine at a concentration equivalent to a few cups of coffee, and in the absence of oxygen (for 3-4 minutes), nerve cells in the hippocampus showed paroxystic electrical activity: in other words, they all fired at the same time, as during epileptic fits. Nothing happened if caffeine was not added to the preparation. Moreover, in the presence of oxygen, caffeine alone failed to produce such neuronal activity. It is therefore the combination of these two factors that induces fits.

Schematically, the caffeine molecule binds to adenosine receptors, thereby blocking the action of adenosine, the endogenous neuromediator, which plays an important role in handling stress. During stressful episodes such as oxygen starvation, adenosine protects the nerve circuits from uncontrolled excitation, which can be detrimental. Caffeine takes the place of adenosine and prevents it from playing its normal role.

This experiment illustrates the detrimental
'"/>

Contact: Marie Christine Simon
presse@tolbiac.inserm.fr
33-1-44-23-60-84
French National Institute for Health and Medical Research (INSERM)
16-Jun-1999


Page: 1 2

Related medicine news :

1. Exercise-induced shortness of breath not always caused by asthma
2. U of M researcher says Viagra may cause permanent vision loss in some men
3. New estimates for the causes of child deaths worldwide
4. Study provides new estimates of the causes of child mortality worldwide
5. New guideline tackles leading cause of mother and child death
6. Decreased levels of good cholesterol in children with Progeria may cause premature heart disease
7. Study finds indoor allergen levels vary, cockroach allergens cause more asthma symptoms
8. LRRK2 gene mutation causes Parkinsons disease in several families
9. Unsafe water and poor sanitation causes 4000 children to die each day
10. Lead in the environment causes violent crime, reports University of Pittsburgh researcher at AAAS
11. Suicidal behaviour caused by antidepressants cannot be ruled out

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/13/2019)... ... June 13, 2019 , ... ... that the final entry deadline in the 2019 competition is extended to July ... the world’s premier business awards program, The IBAs attract nominations from organizations in ...
(Date:6/13/2019)... ... June 13, 2019 , ... ... (AM)-enabled tissue fabrication, patient-matched models and surgical guides, and prosthetics and assistive ... improve patient care. Children with birth defects, soldiers with cranial injuries, conjoined ...
(Date:6/12/2019)... (PRWEB) , ... June 12, 2019 , ... ... for people living with diabetes is pleased to announce that LaurieAnn Scher, MS, ... Association of Diabetes Educators (CT AADE) Diabetes Educator of the Year 2019, honoring ...
(Date:6/12/2019)... ... ... In September of 2018, NVNA and Hospice (NVNA) partnered with Health Recovery Solutions ... full-scale launch in March, NVNA has expanded its program with HRS to provide telehealth ... achieved an average all-cause hospital readmissions rate of 7.3% and has seen a 40% ...
(Date:6/12/2019)... (PRWEB) , ... June 12, 2019 , ... ... is the newest addition to the family of Best Sanitizers’ HACCP Footwear Sanitizing ... food processing facilities, nutraceutical plants, pharmaceutical plants, clinical research labs, and clean rooms ...
Breaking Medicine News(10 mins):
(Date:6/13/2019)... BROOK, Ill. (PRWEB) , ... June 13, 2019 , ... ... diseases, according to an article published in the journal Radiology: Cardiothoracic Imaging . ... European Union alone, prevalence of cocaine consumption was estimated to be around 3.4 million ...
(Date:6/12/2019)... SAN ANTONIO (PRWEB) , ... June 12, 2019 , ... ... year. For many patients undergoing breast cancer surgery, breast reconstruction plays ... rise, the number of overweight patients seeking breast reconstruction is also increasing. There ...
(Date:6/11/2019)... ... June 11, 2019 , ... SABRE , the leading brand in personal ... set to showcase their latest and most innovative personal safety products, including the ... Outdoor Retailer Summer Market 2019 (Booth #39158-UL), June 18-20 in Denver, CO. ...
Breaking Medicine Technology:
Cached News: