HOME >> MEDICINE >> NEWS
Coffee: a cause of neonatal seizures?

Epidemiological observations raised the possibility that coffee was deleterious for newborn babies. For the last ten years the American Food and Drug Administration (FDA) has therefore recommended that pregnant women limit their consumption of coffee.

The first underlying cerebral mechanisms have just been elucidated, by the use of a particular animal model, by INSERM unit 29.

The researchers based their investigations on two observations. First, caffeine contained in the coffee drunk by mothers crosses the fetal blood-brain barrier. On arriving in the brain, the caffeine binds specifically to neuronal adenosine receptors.

Second, fetal oxygenation frequently declines during delivery, especially when contractions last a few minutes, with a risk of hypoxia and severe complications.

It is these two phenomena (caffeine and oxygen starvation) that the researchers reproduced on neurons of the hippocampus, a particular brain structure that appears to be the site of memorization processes. In the presence of caffeine at a concentration equivalent to a few cups of coffee, and in the absence of oxygen (for 3-4 minutes), nerve cells in the hippocampus showed paroxystic electrical activity: in other words, they all fired at the same time, as during epileptic fits. Nothing happened if caffeine was not added to the preparation. Moreover, in the presence of oxygen, caffeine alone failed to produce such neuronal activity. It is therefore the combination of these two factors that induces fits.

Schematically, the caffeine molecule binds to adenosine receptors, thereby blocking the action of adenosine, the endogenous neuromediator, which plays an important role in handling stress. During stressful episodes such as oxygen starvation, adenosine protects the nerve circuits from uncontrolled excitation, which can be detrimental. Caffeine takes the place of adenosine and prevents it from playing its normal role.

This experiment illustrates the detrimental
'"/>

Contact: Marie Christine Simon
presse@tolbiac.inserm.fr
33-1-44-23-60-84
French National Institute for Health and Medical Research (INSERM)
16-Jun-1999


Page: 1 2

Related medicine news :

1. Exercise-induced shortness of breath not always caused by asthma
2. U of M researcher says Viagra may cause permanent vision loss in some men
3. New estimates for the causes of child deaths worldwide
4. Study provides new estimates of the causes of child mortality worldwide
5. New guideline tackles leading cause of mother and child death
6. Decreased levels of good cholesterol in children with Progeria may cause premature heart disease
7. Study finds indoor allergen levels vary, cockroach allergens cause more asthma symptoms
8. LRRK2 gene mutation causes Parkinsons disease in several families
9. Unsafe water and poor sanitation causes 4000 children to die each day
10. Lead in the environment causes violent crime, reports University of Pittsburgh researcher at AAAS
11. Suicidal behaviour caused by antidepressants cannot be ruled out

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/6/2016)... ... 2016 , ... Of the variety of ingredients in the food supply, few ... to common beliefs that hot dogs include “everything but the oink,” today’s wieners are ... combined with meat and poultry in a hot dog recipe can add flavor, keep ...
(Date:12/6/2016)... ... 06, 2016 , ... The NALA, a boutique marketing agency, is proud to ... (TBCF), a nonprofit 501(C)(3) organization providing financial and emotional support to families of children ... TBCF, the NALA recently hosted a Thanksgiving food drive that resulted in four boxes ...
(Date:12/6/2016)... ... December 06, 2016 , ... The Behavioral Health Center of ... the organization as a top behavioral service provider in the country. The award ... staff satisfaction and qualifications, and consumer satisfaction. These areas are measured via a ...
(Date:12/6/2016)... ... December 06, 2016 , ... Experimentation ... research and development, largely due to its potential for revolutionizing human disease treatment. ... and human induced pluripotent stem cells (hiPSCs). , Both platforms have distinct ...
(Date:12/6/2016)... Switzerland (PRWEB) , ... December 06, 2016 , ... ... a one-stop portal for all the knowledge resources, including white papers, guides, ... certificates, and more. , To access more than 9,000 documents, webinars and ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... , Dec. 5, 2016 Spain Glaucoma ... GlobalData,s new report, "Spain Glaucoma Surgery Devices Market Outlook ... Glaucoma Surgery Devices market. The report provides value, in ... prices (USD) within market segements - Canaloplasty Micro Catheters ... company shares and distribution shares data for each of ...
(Date:12/5/2016)... YORK , Dec. 5, 2016 ... penicillin in 1948, antibiotics have emerged as a ... several infectious conditions. In addition, antibiotics are also ... undergone surgery, or immunocompromised patients (cancer patients undergoing ... in healthcare and food production, has rapidly accelerated ...
(Date:12/5/2016)... 2016  Parallax Health Sciences, Inc. ("Parallax" or the ... its pharmaceutical business, RoxSan Pharmacy, Inc. has received a ... all of the 42 states it is currently licensed ... Rashti Pharm . D, Pharmacist in Charge at RoxSan ... business. Medicare B spending last year came to roughly ...
Breaking Medicine Technology:
Cached News: