HOME >> MEDICINE >> NEWS
Coffee: a cause of neonatal seizures?

Epidemiological observations raised the possibility that coffee was deleterious for newborn babies. For the last ten years the American Food and Drug Administration (FDA) has therefore recommended that pregnant women limit their consumption of coffee.

The first underlying cerebral mechanisms have just been elucidated, by the use of a particular animal model, by INSERM unit 29.

The researchers based their investigations on two observations. First, caffeine contained in the coffee drunk by mothers crosses the fetal blood-brain barrier. On arriving in the brain, the caffeine binds specifically to neuronal adenosine receptors.

Second, fetal oxygenation frequently declines during delivery, especially when contractions last a few minutes, with a risk of hypoxia and severe complications.

It is these two phenomena (caffeine and oxygen starvation) that the researchers reproduced on neurons of the hippocampus, a particular brain structure that appears to be the site of memorization processes. In the presence of caffeine at a concentration equivalent to a few cups of coffee, and in the absence of oxygen (for 3-4 minutes), nerve cells in the hippocampus showed paroxystic electrical activity: in other words, they all fired at the same time, as during epileptic fits. Nothing happened if caffeine was not added to the preparation. Moreover, in the presence of oxygen, caffeine alone failed to produce such neuronal activity. It is therefore the combination of these two factors that induces fits.

Schematically, the caffeine molecule binds to adenosine receptors, thereby blocking the action of adenosine, the endogenous neuromediator, which plays an important role in handling stress. During stressful episodes such as oxygen starvation, adenosine protects the nerve circuits from uncontrolled excitation, which can be detrimental. Caffeine takes the place of adenosine and prevents it from playing its normal role.

This experiment illustrates the detrimental
'"/>

Contact: Marie Christine Simon
presse@tolbiac.inserm.fr
33-1-44-23-60-84
French National Institute for Health and Medical Research (INSERM)
16-Jun-1999


Page: 1 2

Related medicine news :

1. Exercise-induced shortness of breath not always caused by asthma
2. U of M researcher says Viagra may cause permanent vision loss in some men
3. New estimates for the causes of child deaths worldwide
4. Study provides new estimates of the causes of child mortality worldwide
5. New guideline tackles leading cause of mother and child death
6. Decreased levels of good cholesterol in children with Progeria may cause premature heart disease
7. Study finds indoor allergen levels vary, cockroach allergens cause more asthma symptoms
8. LRRK2 gene mutation causes Parkinsons disease in several families
9. Unsafe water and poor sanitation causes 4000 children to die each day
10. Lead in the environment causes violent crime, reports University of Pittsburgh researcher at AAAS
11. Suicidal behaviour caused by antidepressants cannot be ruled out

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Coffee cause neonatal seizures

(Date:5/23/2015)... On Saturday, May 23, 2015, over 100 volunteers are ... City exactly five years to the day after the disastrous ... large fire tore through the Branches United Methodist Church and ... middle of the night as neighbors, staff and Branches' children ... though it is suspected that the fire began accidentally. Branches ...
(Date:5/23/2015)... NY (PRWEB) May 23, 2015 On ... that, “the company has been the target of ... a part of the company’s ongoing Information Technology (IT) ... health insurers.” , The most notable attack on ... when Anthem Inc., the nation’s second largest health insurer, ...
(Date:5/23/2015)... Javon Bea Mercy Health System CEO ... Rehabilitation Center, 557 N. Washington St., Janesville, will host ... 5:30-6:30 pm. , The 8-week clinic is lead by ... BSN, who will offer training that encompasses a warm-up, ... and show selection and weekly training plans. , The ...
(Date:5/22/2015)... (PRWEB) May 22, 2015 Pioneer Millworks, ... at the forefront of designing with reclaimed wood, introducing ... in Los Angeles, California. Their newest offerings, Vat 35, ... much-anticipated surface and color to America's largest design event. ... exhibit at each show, anxious to see and feel ...
(Date:5/22/2015)... 22, 2015 Hundreds of federal ... of individuals who allegedly experienced serious internal bleeding ... to move forward in the U.S. District Court, ... Order dated May 4, 2015, the Court has ... electronically stored information. Among other things, the Order ...
Breaking Medicine News(10 mins):Health News:Five Years After Fire, Branches Rebuilds Playground 2Health News:One Headline Making Cyber Attack Sparks Discovery of Another 2Health News:One Headline Making Cyber Attack Sparks Discovery of Another 3Health News:One Headline Making Cyber Attack Sparks Discovery of Another 4Health News:Pioneer Millworks to Reveal New Design Trends with Reclaimed Wood at Dwell on Design in LA 2Health News:Pioneer Millworks to Reveal New Design Trends with Reclaimed Wood at Dwell on Design in LA 3Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 2Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 3Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 4
(Date:5/22/2015)... NEW YORK and KING OF PRUSSIA, ... Hemophilia Foundation (NHF) has awarded CSL Behring ... longstanding and unwavering commitment to advancing science and improving the ... by Paul Perreault , CEO and Managing Director, CSL ... New York City on May 21. ...
(Date:5/22/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/28m7nx/guide_to_prepare ) has announced ... Application Dossiers for Oversea Medical device registration and ... to their offering. The Chinese medical ... the most growth potentiality, which is attracting more ... to penetrate such market. It is estimated that ...
(Date:5/22/2015)... 2015  In a sweeping analysis assessing the current ... Exchange researchers conclude that there remains considerable room ... all age groups, but especially for adolescents and young ... diabetes treatment, underscoring the need to address barriers to ... help type 1 patients achieve optimal metabolic control. ...
Breaking Medicine Technology:National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 2National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 3National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 4China Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation 2China Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation 3Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 2Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 3Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 4Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 5
Cached News: