HOME >> MEDICINE >> NEWS
Coffee: a cause of neonatal seizures?

Epidemiological observations raised the possibility that coffee was deleterious for newborn babies. For the last ten years the American Food and Drug Administration (FDA) has therefore recommended that pregnant women limit their consumption of coffee.

The first underlying cerebral mechanisms have just been elucidated, by the use of a particular animal model, by INSERM unit 29.

The researchers based their investigations on two observations. First, caffeine contained in the coffee drunk by mothers crosses the fetal blood-brain barrier. On arriving in the brain, the caffeine binds specifically to neuronal adenosine receptors.

Second, fetal oxygenation frequently declines during delivery, especially when contractions last a few minutes, with a risk of hypoxia and severe complications.

It is these two phenomena (caffeine and oxygen starvation) that the researchers reproduced on neurons of the hippocampus, a particular brain structure that appears to be the site of memorization processes. In the presence of caffeine at a concentration equivalent to a few cups of coffee, and in the absence of oxygen (for 3-4 minutes), nerve cells in the hippocampus showed paroxystic electrical activity: in other words, they all fired at the same time, as during epileptic fits. Nothing happened if caffeine was not added to the preparation. Moreover, in the presence of oxygen, caffeine alone failed to produce such neuronal activity. It is therefore the combination of these two factors that induces fits.

Schematically, the caffeine molecule binds to adenosine receptors, thereby blocking the action of adenosine, the endogenous neuromediator, which plays an important role in handling stress. During stressful episodes such as oxygen starvation, adenosine protects the nerve circuits from uncontrolled excitation, which can be detrimental. Caffeine takes the place of adenosine and prevents it from playing its normal role.

This experiment illustrates the detrimental
'"/>

Contact: Marie Christine Simon
presse@tolbiac.inserm.fr
33-1-44-23-60-84
French National Institute for Health and Medical Research (INSERM)
16-Jun-1999


Page: 1 2

Related medicine news :

1. Exercise-induced shortness of breath not always caused by asthma
2. U of M researcher says Viagra may cause permanent vision loss in some men
3. New estimates for the causes of child deaths worldwide
4. Study provides new estimates of the causes of child mortality worldwide
5. New guideline tackles leading cause of mother and child death
6. Decreased levels of good cholesterol in children with Progeria may cause premature heart disease
7. Study finds indoor allergen levels vary, cockroach allergens cause more asthma symptoms
8. LRRK2 gene mutation causes Parkinsons disease in several families
9. Unsafe water and poor sanitation causes 4000 children to die each day
10. Lead in the environment causes violent crime, reports University of Pittsburgh researcher at AAAS
11. Suicidal behaviour caused by antidepressants cannot be ruled out

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2017)... ... May 26, 2017 , ... Water damage to the flooring of several ... had left education officials with a number of critical issues to address before students ... to be accomplished with little or no disruption to class schedules. Second, the project ...
(Date:5/24/2017)... ... May 24, 2017 , ... In modern research, success depends ... instruments for research and understanding the basic principles that were designed to drive ... innovations in stereo microscopy for brightfield and fluorescence typically used in laboratories working ...
(Date:5/24/2017)... ... 24, 2017 , ... Altec Products, Inc., a leader in enterprise ... one-day technology conference in San Diego, CA. , At nVerge 2017, Altec will ... utilize and enhance their Sage ERP solutions by providing improved visibility and control to ...
(Date:5/24/2017)... ... May 24, 2017 , ... Drs. ... NY, who have now spent 10 years as clinical instructors for the reputable ... College of Dentistry. Through the program, private practitioners receive cutting-edge clinical training and ...
(Date:5/24/2017)... ... , ... Patients who want to receive cosmetic dentistry procedures such as Invisalign® ... for a consultation, with or without a referral. Dr. Bedich enjoys improving the appearance ... , Dr. Bedich offers a variety of cosmetic dentistry services at his practice that ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... MARLBOROUGH, Mass., May 10, 2017 Hologic, Inc. ... financial results for the fiscal second quarter ended April ... (EPS) of $1.84 increased 666.7% compared to the prior ... business resulted in a significant gain, while non-GAAP diluted ... increased 3.2%, or 3.8% in constant currency terms.  Excluding ...
(Date:5/10/2017)... Md. , May 10, 2017 CSSi, ... solutions for the clinical research industry, is proud to ... www.CSSiEnroll.com . The new website features both enriched content ... user experience and enhances the company,s already well-established position ... industry. "After many months of hard ...
(Date:5/9/2017)... 9, 2017  Semler Scientific, Inc. (OTCQB: SMLR), ... to improve the clinical effectiveness and efficiency of ... first quarter ended March 31, 2017. ... customers to identify when preventive care options are ... like heart attacks or strokes occur," said ...
Breaking Medicine Technology:
Cached News: