Combination therapy does not appear to benefit cardiac patients before heart catheter procedure

d point of the trial, was 13 percent in the reteplase plus abciximab group and 11.5 percent in the abciximab group," the researchers report. "The mean (average) difference in final infarct size of the left ventricle between the reteplase plus abciximab group and the abciximab group was 1.3 percent." The researchers noted that several hours after the drug administration, patients receiving the combination therapy had superior blood flow through the blocked artery. The researchers also found, "the cumulative 6-month incidence of the composite end point (death, recurrent MI, or stroke) was also comparable between the two treatment groups, whereas there was a trend toward more major bleeding events with reteplase plus abciximab."

"In conclusion, the findings of this trial show that early administration of reteplase plus abciximab does not lead to a reduction of infarct size compared with abciximab alone in patients with acute MI referred for PCI. In addition, clinical outcome was not improved by combination therapy." (JAMA. 2004;291:947-954. Available post-embargo at JAMA.com)


Contact: Adnan Kastrati, M.D.
JAMA and Archives Journals

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