HOME >> MEDICINE >> NEWS
Combination therapy w/ ACTOS (pioglitazone HCI) shown to improve components of diabetic dyslipidemia

BOSTON, April 30, 2004 Results of three studies show the oral anti-diabetic agent ACTOS (R) (pioglitazone HCl), in combination with a sulfonylurea, metformin or insulin, resulted in triglyceride decreases and high-density lipoprotein (HDL) cholesterol increases that demonstrated statistically significant improvements from baseline.

These studies also showed that, in addition to increasing low-density lipoprotein (LDL) cholesterol particle size, ACTOS can significantly increase the size and buoyancy of HDL particles. The findings were presented today at the 13th Annual Meeting and Clinical Congress of the American Association of Clinical Endocrinologists (AACE) in Boston.

"The data are important because they underscore the additional lipid benefits of ACTOS beyond its ability to effectively manage glucose levels and positively affect triglyceride and HDL cholesterol levels," said Mehmood Khan, M.D., F.A.C.E., senior vice president for medical and scientific affairs, Takeda Pharmaceuticals North America. "While it's well-established that increases in LDL cholesterol particle size are associated with ACTOS therapy, these new data show that HDL or 'good' cholesterol particles are similarly affected, which may further expand the lipid benefits of ACTOS."

People with diabetes are about twice as likely as those without diabetes to have high triglyceride and low HDL cholesterol levels, a condition commonly referred to as diabetic dyslipidemia. Studies have shown that the presence of large, buoyant HDL particles instead of small, dense particles may be associated with reduced cardiovascular risks.

In addition, people with diabetes tend to have a higher proportion of small, dense LDL particles, which may lead to an increase in cardiovascular risk. Smaller, more dense LDL particles are thought to more easily penetrate arterial walls to form atherosclerotic plaque.

Study Design

These studies were conducted to
'"/>


30-Apr-2004


Page: 1 2 3

Related medicine news :

1. Combination treatment helps thyroid cancer patients live longer
2. Combination therapy, not medication alone, most effective for treating children with OCD
3. Combination of erection pill and testosterone gel may benefit men who fail treatment with pill alone
4. Combination PET/CT should be used to determine stage of non-small cell lung cancer
5. Combination of toxin and poison may be novel treatment for leukemia
6. Combination drug therapy could substantially improve symptoms of rheumatoid arthritis
7. Combination therapy does not appear to benefit cardiac patients before heart catheter procedure
8. Combination drug therapy offers hope for malaria treatment
9. Combination therapy significantly delays progression of benign prostatic hyperplasia
10. Combination, order of anti-HIV drugs make a difference in first-time recipients
11. Combination of HIV/malaria increases complications during pregnancy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/13/2018)... ... December 13, 2018 , ... LifeStation today announced the availability of Find My Loved One, a ... One gives caregivers the ability to locate a loved one at any time. With ... peace of mind for children, relatives, and caregivers. , Here’s how it works: ...
(Date:12/10/2018)... ... , ... Becker's Healthcare named the following institutions to the ... , The hospitals named on this list are national leaders in cardiovascular healthcare ... groundbreaking procedures and remain on the forefront of heart care today. Others are ...
(Date:12/10/2018)... ... December 10, 2018 , ... ... Emergency Room and Florida Hospital Wesley Chapel recently received the 2018 Press Ganey ... patient experience. The award for both emergency and inpatient services is measured through ...
(Date:12/8/2018)... SAN MATEO, Calif. (PRWEB) , ... December 07, 2018 , ... ... Medical Guardian a leading provider of innovative medical alert systems, to its list ... the Best for Premium Features . , Medical Guardian was one of fourteen ...
(Date:12/6/2018)... ... December 06, 2018 , ... We all know ... are alternative solutions. M.D.-formulated Relaxium Calm is a dietary supplement developed to promote ... Sensoril®, an extract of the ashwagandha root. Ashwagandha is a powerful herb that ...
Breaking Medicine News(10 mins):
(Date:12/6/2018)... ... ... It’s easy to get sick during cold and flu season, and when one person catches ... flu can spread it to others up to about 6 feet away. Most experts think ... or talk. While most people recover from the flu within seven to ten days, it ...
(Date:12/6/2018)... ... ... Every day, and especially during the holidays, the home kitchen is a hotspot ... throw away) bacteria-filled messes, and to prevent germs from spreading. Kitchen towels and sponges ... kitchen surfaces and increase the odds of cross-contamination. And cleaning sponges and dishtowels is ...
(Date:12/5/2018)... ... December 05, 2018 , ... Smile Brands Inc. has been honored ... from the 43rd to 25th position on the list of the top 100 ... its 11th year, relies solely on the input of employees, who elect to provide ...
Breaking Medicine Technology:
Cached News: