HOME >> MEDICINE >> NEWS
Combined kidney and bone marrow transplantation allows patients to discontinue anti-rejection drugs

An experimental treatment protocol involving combined kidney and bone marrow transplantation has enabled several patients to accept their transplanted kidney without immunosuppressive drugs, reports a researcher from Massachusetts General Hospital (MGH). Speaking at a press briefing today at the Congress of the International Transplantation Society, Megan Sykes, MD, head of the bone marrow transplantation section of the MGH Transplantation Biology Research Center (TBRC), described how infusing the recipients with bone marrow from their donors immediately after the transplant surgery induced a state of mixed chimerism, a blending of donor and recipient immune systems.

All of the patients Sykes described had developed kidney failure as a result of multiple myeloma, a cancer of the bone marrow. Traditionally, such patients had no good treatment options. They were not eligible for kidney transplantation because of their cancer, and the kidney failure made them unable to tolerate the toxic aspects of standard bone marrow transplantation, which has been used for some myeloma patients. For many years Sykes and her colleagues at MGH -- along with collaborators at BioTransplant Incorporated of Charlestown, Mass. -- have been studying mixed chimerism and its application for both treatment of blood-cell cancers and for inducing tolerance, a state in which an organ recipient's immune system no longer recognizes the donor's tissues as foreign.

MGH TBRC researchers and Thomas R. Spitzer, MD, director of the MGH Bone Marrow Transplant Unit, developed a less toxic bone marrow transplantation protocol in which the recipient's immune system is only suppressed instead of totally destroyed. Utilizing this approach, called non-myeloablative bone marrow transplantation, the first patient received a combined transplant in September 1998. As reported the following year, the patient's immunosuppression was tapered off after the procedure and discontinued on the 73r
'"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
26-Aug-2002


Page: 1 2

Related medicine news :

1. Combined drug therapy prevents progression of prostate enlargement
2. Combined therapies benefit heart failure patients
3. Combined Use Of New, Non-Invasive Screening Techniques In First Trimester May Yield Earlier Evidence Of Fetal Birth Defects
4. University Of Texas Southwestern Studies Excimer Laser For Treating Farsightedness With Combined Astigmatism
5. Prospects For Surviving Heart Attack Emergency Improve When Clot-Busting Drugs Are Combined With Balloon Pump Inserted In Aorta
6. Combined Therapy Improved Care Of Patients With Type 2 Diabetes Proper Use Of New Oral Medications Evaluated
7. Study shows promise in identifying kidney failure
8. New marker for early diagnosis of kidney failure identified
9. Mouse model reveals potential way to reduce cardiac deaths in kidney patients
10. Age shouldnt be a factor in kidney transplantation
11. Infectious microorganism linked to kidney stones and other diseases

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/2/2020)... , ... September 02, 2020 , ... ... software for healthcare payers administering Medicare Advantage and Special Needs plans, is proud ... by America’s Health Insurance Plans (AHIP). RAM is supporting the event as a ...
(Date:9/1/2020)... ... September 01, 2020 , ... Dr. Kiran Gill ... aesthetic surgery of the face, breast, and body. In 2018, she founded Aesthetics ... plastic surgery and aesthetic practice in Southwest Florida. Dr. Gill and her team ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... Want to ... 1, Cerebral Palsy Alliance Research Foundation (CPARF) is thrilled to launch its fourth annual ... research. A fully virtual challenge, STEPtember meets everyone wherever they are at this moment ...
(Date:8/31/2020)... ... ... “PTS” with Mediation & Hypnosis , At this very turbulent time in the world, ... immense stress, and right now are needing serious relief from a constant state of endless ... experiencing a great degree of emotional discomfort, be it fear or worrying about their income ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... Craig Mandeville was named an Entrepreneur Of The Year® 2020 Florida Award finalist. ... business leaders whose ambitions deliver innovation, growth and prosperity as they build and ...
Breaking Medicine News(10 mins):
(Date:8/27/2020)... CONSHOHOCKEN, Pa. (PRWEB) , ... August 27, 2020 ... ... and care coordination software, today announced the successful completion of their 2020 System ... as well as their HITRUST® interim assessment and MARS-E compliance assessment. These achievements ...
(Date:8/27/2020)... ... August 27, 2020 , ... Bleep LLC, maker of the DreamPort mask-less CPAP ... the company’s new spokesperson. , “In my line of work, a good night of ... Bleep DreamPort it was a Bleeping no brainer for me,” said Jensen. “From the ...
(Date:8/27/2020)... ... , ... The GHT Companies , a leading developer and distributor of ... Diego with a press conference at its manufacturing facility in Vista. Here ... representing an overall donation result exceeding $30,000 to Feeding San Diego, Who: Jim ...
Breaking Medicine Technology:
Cached News: