HOME >> MEDICINE >> NEWS
Common antidepressants lower effects of tamoxifen in many women

INDIANAPOLIS - Additional evidence that a class of antidepressants can reduce the effectiveness of tamoxifen has been published by researchers from the Indiana University School of Medicine, the University of Michigan and Johns Hopkins University.

Results of the trial are published in the January 5 issue of the Journal of the National Cancer Institute.

The large clinical trial confirmed data from an earlier study showing that selective serotonin reuptake inhibitor antidepressants may hinder the effectiveness of tamoxifen, a drug commonly administered to breast cancer patients. The study also reports that researchers now have pinpointed genetic types that are linked with this effect.

Led by David Flockhart, M.D., Ph.D., an IU professor of medicine and director of the Division of Clinical Pharmacology, the researchers examined the effects of SSRIs in women who were prescribed tamoxifen to treat the common side effects of breast cancer therapy which include depression and hot flashes.

More than a fourth of the women enrolled in this study were prescribed SSRIs. The study showed that the various SSRIs taken by the women have different effects on the amount of active tamoxifen byproducts in their blood.

"This is important because previous studies have shown that when tamoxifen is broken down, the resulting molecules are extremely powerful at blocking estrogen receptors and thereby exert a cancer-inhibitive effect," said Dr. Flockhart.

"We have withheld clinical recommendations, because at this point we don't have final data," said Dr. Flockhart. The study makes clear that knowledge of a drug's ability to inhibit CYP2D6 enzyme activity may help clinicians anticipate important drug interactions. Genetic testing may help identify a group of women who may experience greater benefit from tamoxifen or those who may benefit more from one SSRI than another, he said.

This study is the first large-scale clinical trial to
'"/>

Contact: PR Staff
caisen@iupui.edu
317-274-7722
Indiana University
20-Jan-2005


Page: 1 2

Related medicine news :

1. Common anesthetics appear safe for developing fetal brain
2. Common schizophrenia symptoms often overlooked by physicians, according to expert panel
3. Common antidepressant may affect youths bone development
4. Common epilepsy treatment to be used for bulimia nervosa
5. Mouth sores: Common complaints of students
6. Common drug, given promptly, reduces incidence of post-traumatic stress disorder, small study finds
7. New Commonwealth Fund analysis compares candidtes health care reform proposals
8. Common heart surgery potentially dangerous
9. Common treatment for cancer pain stimulates breast tumor growth in mice
10. Common diabetes drug causes arteries to spasm, endangering heart
11. Commonly prescribed antibiotic ineffective for treating bronchitis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... HAVEN, Conn. (PRWEB) , ... August 31, 2020 ... ... medical device intended to improve outcomes for patients with advanced heart failure, today ... Research (SBIR) grant in the amount of $555,358 from the National Heart, Lung, ...
(Date:8/28/2020)... ... August 28, 2020 , ... WHAT , Hespiro™ is ... with respiratory conditions, including COVID-19, while reducing the need for scarce mechanical ventilators. ... exhaled gas and scrubs it free of carbon dioxide in a completely closed ...
(Date:8/28/2020)... ... August 28, 2020 , ... Integrated Viral Protection ... the first Florida school to deploy its breakthrough Mobile Biodefense Indoor Air Protection System ... True North Classical Academy plans to fully reopen equipped with the filtration system on ...
(Date:8/27/2020)... ... August 27, 2020 , ... Walk-in Dermatology’s SK-IN Medical ... its Greenvale, New York location. , Loren received her New York esthetic ... certified in chemical peels, microdermabrasion, Hydrafacial MD, dermaplaning, facial lymphatic, and various laser ...
(Date:8/26/2020)... ... August 26, 2020 , ... ... the upcoming Global Inclusion Online Forum, leading a session entitled, “A CEO Guide ... event of this magnitude designed to bring together the world’s leading diversity and ...
Breaking Medicine News(10 mins):
(Date:8/31/2020)... Israel (PRWEB) , ... August 31, 2020 , ... ... specialize in wellness-related technologies, today announced that they have invested $400,000 in PopBase, ... that ran in collaboration with the Global Wellness Institute (GWI). , The ...
(Date:8/31/2020)... PHOENIX (PRWEB) , ... August 31, 2020 , ... ... Mobile Sanitizing and Disinfecting - a broad-spectrum sanitization, disinfection and deodorization provider ... company will offer door-to-door sanitizing and disinfecting services for businesses and residents throughout ...
(Date:8/28/2020)... ... 2020 , ... Cano Health, LLC, a leading population health ... Antonio is happy to announce that it has selected Tejano musician Jay Perez ... will serve as community advisor, advertising talent, and creative consultant for Cano Health, ...
Breaking Medicine Technology:
Cached News: