HOME >> MEDICINE >> NEWS
Common diabetes drug causes arteries to spasm, endangering heart

The oral medications most widely used to lower blood-sugar levels in patients with type 2 diabetes are likely to increase the risk of spasm of the coronary arteries, reports a University of Chicago-based research team in the July 15 issue of the Journal of Clinical Investigation. Constricted arteries increase blood pressure and decrease blood flow to the heart, causing chest pain and even sudden death, shows the study, which focused on mice with a genetic defect that duplicates the actions of these drugs.

Sulfonylurea drugs are the mainstay of therapy for non-insulin-dependent diabetes, which affects an estimated 15 million people in the United States. These drugs stimulate the beta cells of the pancreas to squeeze out more insulin and also make insulin more effective.

Since the early 1970s, however, several studies have suggested that sulfonylurea drugs may actually increase cardiovascular problems in diabetic patients. The link between these drugs and heart damage has been disputed, because it was not clear -- until now -- exactly how such medications increased cardiovascular risk. The new study demonstrates a direct link between the receptor for sulfonylurea drugs and coronary arterial spasm, heart damage and death.

"This study, even though it involved mice, argues that from now on we should think twice, or maybe more than twice, about using the sulfonylureas, particularly if other options are available," said Elizabeth McNally, M.D., Ph.D., a cardiologist at the University of Chicago and director of the study. She adds that "other options are always available."

The discovery grew out of a laboratory problem. In 1999, William Chutkow, an M.D.-Ph.D. student working in the lab of diabetes specialist Charles Burant at the University of Chicago (Burant is now at U. Michigan), engineered mice lacking the gene for a sulfonylurea receptor known as SUR2. Although these mice initially appeared normal, they tended to die suddenly.
'"/>

Contact: John Easton
jeaston@uchospitals.edu
773-702-6241
University of Chicago Medical Center
1-Jul-2002


Page: 1 2 3

Related medicine news :

1. Common anesthetics appear safe for developing fetal brain
2. Common schizophrenia symptoms often overlooked by physicians, according to expert panel
3. Common antidepressants lower effects of tamoxifen in many women
4. Common antidepressant may affect youths bone development
5. Common epilepsy treatment to be used for bulimia nervosa
6. Mouth sores: Common complaints of students
7. Common drug, given promptly, reduces incidence of post-traumatic stress disorder, small study finds
8. New Commonwealth Fund analysis compares candidtes health care reform proposals
9. Common heart surgery potentially dangerous
10. Common treatment for cancer pain stimulates breast tumor growth in mice
11. Commonly prescribed antibiotic ineffective for treating bronchitis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/2/2020)... ... 2020 , ... The Northern Virginia Community College Educational Foundation (NOVA Foundation) is ... of Palm Beach, Florida. Ms. Howe is adding to her existing endowed scholarship ... more important than ever given the current pandemic. Ms. Howe has also generously donated ...
(Date:4/1/2020)... ... April 01, 2020 , ... According to data released by Power ... in need of publicly funded contraception live in counties impacted by the implementation of ... have lost some or all of their Title X resources. , The domestic ...
(Date:3/30/2020)... ... March 30, 2020 , ... ... patients, continuing its commitment to provide comprehensive and compassionate mental health and wellness ... Achieve Medical Center’s UpDox platform for telemedicine services including initial consultations, evaluations, and ...
(Date:3/28/2020)... ... March 27, 2020 , ... ... is now offering telemedicine as an alternative approach to seeing their patients. ... doctors in the comfort of their own home or office using video conference ...
(Date:3/27/2020)... ... , ... On March 27th, 2020, Talos Health Solutions , kicked off ... and caregivers living in the US. This free online conference will be available to ... will focus on asthma symptoms, the different kinds of asthma, treatment options, the experience ...
Breaking Medicine News(10 mins):
(Date:4/9/2020)... , ... April 09, 2020 , ... ... addressing unmet needs in the field of urology, today announced that Brett Hill, ... as a UroLift® Center of Excellence. The designation recognizes that Dr. Hill has ...
(Date:4/7/2020)... LOS ANGELES (PRWEB) , ... April 07, 2020 ... ... announced the launch of her sourcing website to support businesses looking to quickly ... sciences and healthcare industry, RED Company has been sourcing goods internationally and making ...
(Date:4/5/2020)... SANTA CLARA, Calif. (PRWEB) , ... April 04, ... ... huge wave of COVID-19 infections, urgent needs arise for medical supplies, diagnostics, and ... of patients and medical professionals at risk. , Tran & Associates ...
Breaking Medicine Technology:
Cached News: