HOME >> MEDICINE >> NEWS
Component of aspirin prevents antibiotic-induced deafness

Active component of aspirin prevents antibiotic-induced deafness, say U-M scientists. Clinical trial under way in humans.

ANN ARBOR---University of Michigan scientists have found that salicylate---the active component of ordinary aspirin---can prevent deafness in guinea pigs exposed to a common class of antibiotics that destroy delicate hair cells in the inner ear. Results of the study are published in the July 1999 issue of the journal Laboratory Investigation.

A clinical trial currently under way at a hospital in Xi'an, China, will determine whether aspirin is as effective in people as it is in guinea pigs, according to Jochen Schacht, Ph.D., a biochemist in the otolaryngology department of the U-M Medical School and a consultant on the clinical trial.

Discovered in the 1940s, aminoglycosides---which include streptomycin, gentamicin, neomycin and others---are the most widely used antibiotics in the world even though they are known to cause hearing loss and balance disorders in a significant percentage of individuals who take them.

"These drugs are a serious problem in rural areas of developing countries, especially China and Southeast Asia, where they are widely used because they are so effective and inexpensive," Schacht said. "All too frequently, they are the only affordable drugs available. Studies of deaf-mutism in southeastern China showed that two-thirds of the cases were caused by aminoglycosides."

In the United States and other industrialized countries, aminoglycosides are most often used to treat people with serious infections who have not responded to other antibiotics. "The increasing worldwide threat of antibiotic-resistant tuberculosis in the wake of AIDS, however, makes it likely that their use will increase in the future," Schacht added.

After years of research, Schacht and his colleagues reported in 1995 that gentamicin combines with iron in the body to trigger production of free radicals---unstable mo
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
734-647-1844
University of Michigan
13-Jul-1999


Page: 1 2 3

Related medicine news :

1. Component of green tea protects injured livers in mice
2. Talk with the experts: The American Psychiatric Associations 1999 Fall Components Meeting
3. Penn State Chemist Identifies New Lime Aroma Component
4. X-ray Microscope Designed To Study Jet Engine Components Now Probes Tooth Dentin
5. Many postmenopausal women with cardiovascular disease dont use lifesaving aspirin therapy
6. Survivors who stop taking aspirin increase risk of another stroke
7. Study says 43% of US adults at risk of heart disease are not utilizing aspirin therapy
8. Low-dose aspirin and stomach ulcer medications better for heart patients with GI complications
9. Statins and aspirin may protect against severe vision loss in elderly
10. One in five asthmatics are highly sensitive to aspirin
11. Baby and coated aspirin equally effective in thinning of blood when taken in combination with Plavix

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
(Date:6/25/2016)... , ... June 25, 2016 , ... On Friday, June ... a Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments ... of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced ... feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as a ... has released tools for healthy coping following a traumatic event. , Trauma sufferers tend ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Conference and Scientific Sessions in Dallas that it will receive two significant new ... the grants came as PHA marked its 25th anniversary by recognizing patients, medical ...
(Date:6/24/2016)... San Diego, CA (PRWEB) , ... June 24, 2016 , ... ... up with the American Cancer Society and the Road To Recovery® program to drive ... care to seniors and other adults to ensure the highest quality of life and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... India , June 24, 2016 ... Needles Market by Type (Standard Pen Needles, Safety Pen ... Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, ... by MarketsandMarkets, This report studies the market for the ... expected to reach USD 2.81 Billion by 2021 from ...
(Date:6/24/2016)... , Belgium , June ... MKT: VNRX), today announced the appointment of Dr. ... of Directors as a Non-Executive Director, effective June ... Company,s Audit, Compensation and Nominations and Governance Committees.  ... Dr. Futcher will provide independent expertise and strategic ...
(Date:6/23/2016)...  MedSource announced today that it has selected ... of choice.  This latest decision demonstrates MedSource,s commitment ... clients by offering a state-of-the-art electronic data capture ... as the EDC platform of choice in exchange ... has long been a preferred EDC platform by ...
Breaking Medicine Technology:
Cached News: