HOME >> MEDICINE >> NEWS
Component of aspirin prevents antibiotic-induced deafness

Active component of aspirin prevents antibiotic-induced deafness, say U-M scientists. Clinical trial under way in humans.

ANN ARBOR---University of Michigan scientists have found that salicylate---the active component of ordinary aspirin---can prevent deafness in guinea pigs exposed to a common class of antibiotics that destroy delicate hair cells in the inner ear. Results of the study are published in the July 1999 issue of the journal Laboratory Investigation.

A clinical trial currently under way at a hospital in Xi'an, China, will determine whether aspirin is as effective in people as it is in guinea pigs, according to Jochen Schacht, Ph.D., a biochemist in the otolaryngology department of the U-M Medical School and a consultant on the clinical trial.

Discovered in the 1940s, aminoglycosides---which include streptomycin, gentamicin, neomycin and others---are the most widely used antibiotics in the world even though they are known to cause hearing loss and balance disorders in a significant percentage of individuals who take them.

"These drugs are a serious problem in rural areas of developing countries, especially China and Southeast Asia, where they are widely used because they are so effective and inexpensive," Schacht said. "All too frequently, they are the only affordable drugs available. Studies of deaf-mutism in southeastern China showed that two-thirds of the cases were caused by aminoglycosides."

In the United States and other industrialized countries, aminoglycosides are most often used to treat people with serious infections who have not responded to other antibiotics. "The increasing worldwide threat of antibiotic-resistant tuberculosis in the wake of AIDS, however, makes it likely that their use will increase in the future," Schacht added.

After years of research, Schacht and his colleagues reported in 1995 that gentamicin combines with iron in the body to trigger production of free radicals---unstable mo
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
734-647-1844
University of Michigan
13-Jul-1999


Page: 1 2 3

Related medicine news :

1. Component of green tea protects injured livers in mice
2. Talk with the experts: The American Psychiatric Associations 1999 Fall Components Meeting
3. Penn State Chemist Identifies New Lime Aroma Component
4. X-ray Microscope Designed To Study Jet Engine Components Now Probes Tooth Dentin
5. Many postmenopausal women with cardiovascular disease dont use lifesaving aspirin therapy
6. Survivors who stop taking aspirin increase risk of another stroke
7. Study says 43% of US adults at risk of heart disease are not utilizing aspirin therapy
8. Low-dose aspirin and stomach ulcer medications better for heart patients with GI complications
9. Statins and aspirin may protect against severe vision loss in elderly
10. One in five asthmatics are highly sensitive to aspirin
11. Baby and coated aspirin equally effective in thinning of blood when taken in combination with Plavix

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/26/2017)... ... February 26, 2017 , ... ODH, Inc.™ announced ... February 27-28 at the Sheraton Pentagon City Hotel in Arlington, VA. ODH’s director of ... use behavioral health analytics to improve Medicaid population health management. , ODH will also ...
(Date:2/24/2017)... ... February 24, 2017 , ... Houston ... at his office, Antoine Dental Center. Currently, patients can get single dental implants ... apply, but patients can learn more about these offers by contacting Antoine Dental ...
(Date:2/24/2017)... ... ... The Smart Machine Age is here, and it’s disrupting everything. Not only could ... in the United States may be taken over by technology in the next five ... steamrolls over colleagues is drawing to a close. Success will belong to those who ...
(Date:2/24/2017)... ... February 24, 2017 , ... With ProGlass Prism users now have the ... have total control over position, rotation, distortion, edge softness, edge blur, chromatic aberration, individual ... X. , With ProGlass Prism users are given the tools and effects to ...
(Date:2/24/2017)... , ... February 24, 2017 , ... The Radiology ... excellence in radiology marketing programs at the annual Building Better Radiology Marketing Programs ... Fort Worth Hotel in Fort Worth, Texas. Nine awards are given out in five ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... , Feb 24, 2017 Research and Markets ... and Strategies - 2016" report to their offering. ... The latest research Dry eye Drugs Price ... the global Dry eye market. The research answers the following questions: ... Dry eye and their clinical attributes? How are they positioned in the ...
(Date:2/24/2017)... HILL, N.C. , Feb. 24, 2017 /PRNewswire/ ... are exploring ways to increase their self-service capabilities ... Health Care Providers (HCPs). New research ... many pharma organizations have developed self-service website portals ... electronically.  This is just one of many findings ...
(Date:2/24/2017)... YORK , Feb. 23, 2017 Report analyzes ... report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... and forecasts are provided for the period 2015 through 2022. ... Market data and analytics are derived from primary and secondary ...
Breaking Medicine Technology:
Cached News: