HOME >> MEDICINE >> NEWS
Component of aspirin prevents antibiotic-induced deafness

Active component of aspirin prevents antibiotic-induced deafness, say U-M scientists. Clinical trial under way in humans.

ANN ARBOR---University of Michigan scientists have found that salicylate---the active component of ordinary aspirin---can prevent deafness in guinea pigs exposed to a common class of antibiotics that destroy delicate hair cells in the inner ear. Results of the study are published in the July 1999 issue of the journal Laboratory Investigation.

A clinical trial currently under way at a hospital in Xi'an, China, will determine whether aspirin is as effective in people as it is in guinea pigs, according to Jochen Schacht, Ph.D., a biochemist in the otolaryngology department of the U-M Medical School and a consultant on the clinical trial.

Discovered in the 1940s, aminoglycosides---which include streptomycin, gentamicin, neomycin and others---are the most widely used antibiotics in the world even though they are known to cause hearing loss and balance disorders in a significant percentage of individuals who take them.

"These drugs are a serious problem in rural areas of developing countries, especially China and Southeast Asia, where they are widely used because they are so effective and inexpensive," Schacht said. "All too frequently, they are the only affordable drugs available. Studies of deaf-mutism in southeastern China showed that two-thirds of the cases were caused by aminoglycosides."

In the United States and other industrialized countries, aminoglycosides are most often used to treat people with serious infections who have not responded to other antibiotics. "The increasing worldwide threat of antibiotic-resistant tuberculosis in the wake of AIDS, however, makes it likely that their use will increase in the future," Schacht added.

After years of research, Schacht and his colleagues reported in 1995 that gentamicin combines with iron in the body to trigger production of free radicals---unstable mo
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
734-647-1844
University of Michigan
13-Jul-1999


Page: 1 2 3

Related medicine news :

1. Component of green tea protects injured livers in mice
2. Talk with the experts: The American Psychiatric Associations 1999 Fall Components Meeting
3. Penn State Chemist Identifies New Lime Aroma Component
4. X-ray Microscope Designed To Study Jet Engine Components Now Probes Tooth Dentin
5. Many postmenopausal women with cardiovascular disease dont use lifesaving aspirin therapy
6. Survivors who stop taking aspirin increase risk of another stroke
7. Study says 43% of US adults at risk of heart disease are not utilizing aspirin therapy
8. Low-dose aspirin and stomach ulcer medications better for heart patients with GI complications
9. Statins and aspirin may protect against severe vision loss in elderly
10. One in five asthmatics are highly sensitive to aspirin
11. Baby and coated aspirin equally effective in thinning of blood when taken in combination with Plavix

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/5/2018)... CITY, Tenn. and DALLAS, Texas (PRWEB) , ... ... ... aesthetics team, again proved its leading SkinPen Precision device is setting a new ... of its record-setting Aesthetics Everything win. , Each year this award is presented ...
(Date:12/5/2018)... ... December 05, 2018 , ... Marking its seventh year, Pacifica Graduate ... Toast Heard ‘Round the World” on New Year’s Eve. Each year event organizer ... (alumni, students, faculty members, staff, families, and friends of the institution) to join the ...
(Date:12/5/2018)... ... December 05, 2018 , ... What is Rosacea: ... are poorly understood. It manifests on the face, especially the cheeks, chin, nose ... cause enormous social and psychological problems. , Although it is considered incurable, the ...
(Date:12/5/2018)... (PRWEB) , ... December 05, 2018 , ... You can ... and LTRMN. , LTRMN , is a powerhouse in the cannabis industry with ... True Terpenes is an industry leading, award winning , botanical terpene ...
(Date:11/29/2018)... YORK (PRWEB) , ... November 29, 2018 , ... ... bold mission to alleviate and treat chronic pain without opiates. This new and ... treatments to reduce or eliminate chronic pain for both children and adults. ...
Breaking Medicine News(10 mins):
(Date:12/8/2018)... ... ... Cardiologist Ernst von Schwarz, MD says that women can experience unique warning ... by their doctors. “This can be especially dangerous in younger women who may not ... symptoms that are unique to women so they may become better advocates for themselves ...
(Date:12/6/2018)... , ... December 06, 2018 , ... Last year, 172 ... officials, 80% of those children had not gotten the vaccine. Vaccination is the first ... as flu shots reduce the severity of the illness if infected. Along with getting ...
(Date:12/6/2018)... ... December 06, 2018 , ... ... with it, more answers for the millions of Americans and people worldwide who ... available treatment facilities, the renowned Alternative to Meds Center utilizes the tenets of ...
Breaking Medicine Technology:
Cached News: