While several researchers have focused their attention on developing these mussel adhesive proteins into a type of super-glue, Messersmith reasoned that the same compounds could be used to anchor a repellant component. He decided to attach the sticky DOPA molecule to a well-known repellant molecule, polyethylene glycol (PEG).
The result: A two-sided compound whose sticky side attaches to internal surfaces, but whose nonstick side can resist protein and cell attachment, such as that encountered by implanted medical devices.
In the current study, Messersmith and his associates demonstrated that the new compound could be easily attached to gold and titanium surfaces (common implant materials), rendering these surfaces resistant to cell attachment for up to two weeks. Although some antifouling coatings can fight contamination for a similar length of time, the researchers are optimistic that their compound can eventually be made to last much longer, perhaps permanently.
Just as mussel adhesive protein tends to bind to practically any surface it encounters, the researchers believe that the new compound can similarly attach to other surfaces used for medical devices, including stainless steel and plastic. Preliminary studies involving attachment of the compound to polymer surfaces appear promising, they say.
But antifouling coatings are not the only means of preventing device-related complications following implant surgery: Pills containing anticoagulants or antibiotics are given to some patients, according to the researchers.
The new compound has not yet u
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Contact: Beverly Hassell
b_hassell@acs.org
202-872-4065
American Chemical Society
7-Apr-2003