Comprehensive gene profiles hold promise for improving outcome of pediatric leukemia

(MEMPHIS, TENN.--October 31 , 2003) Investigators at St. Jude Children's Research Hospital have identified the genetic fingerprints of the major subtypes of pediatric acute lymphoblastic leukemia (ALL), the most commonly treated pediatric cancer. The achievement promises to enhance the ability of physicians to more accurately diagnose ALL, improve their ability to accurately monitor a patient's response to therapy, and eventually, develop more effective and less-toxic drugs to treat this cancer.

The findings will also provide an invaluable resource for exploring the biological events that turn normal white blood cells into leukemic cells, according to James Downing, M.D., chair of the St. Jude department of Pathology. Downing is senior author of a report on this work, which appears in the October issue of Blood.

"Our ability to genetically fingerprint the different subtypes of ALL is extremely important," Downing said. "The only way to know how aggressively to treat a specific patient is to know which subtype of ALL the child has, since each subtype has a different prognosis."

The current work by the St. Jude team builds on work they previously published in 2002. In that study, the team used a single gene chip to identify the known subtypes of ALL. The current study used much higher density gene chips, which provided nearly complete coverage of the human genome. As a result, almost 60 percent of the ALL genes identified in the present study are new.

Pediatric ALL is one of the great success stories of modern cancer therapies, with overall event-free survival rates approaching 80 percent, according to Downing. Part of this success is due to the realization by researchers that there are different subtypes of ALL, each of which must be treated with a different level of intensity. This so-called risk-adapted therapy depends on accurately defining a patient's relative risk of relapse following treatment, and doing so before treatment begins. <

Contact: Bonnie Cameron
St. Jude Children's Research Hospital

Page: 1 2 3

Related medicine news :

1. The National Comprehensive Cancer Network recognizes National Cancer Fatigue Awareness Day
2. Cedars-Sinai Comprehensive Cancer Center adds new dimension in radiation treatment
3. Comprehensive pituitary center at Cedars-Sinai brings together under one roof medical, surgical, research and other components
4. American Psychiatric Association Plans First Comprehensive Guidelines For HIV/AIDS Treatment
5. Comprehensive Heart Failure Program At Cedars-Sinai Medical Center
6. Comprehensive Effort Needed To Prevent And Treat Traumatic Injuries
7. Most Comprehensive Study Of Its Kind Shows Common Asthma Medications Dont Cause Behavioral Problems In Children, According To The Journal Pediatrics
8. Research study profiles indoor tanners
9. Diabetic women on hormone replacement therapy have better glycemic and lipid profiles
10. Gene expression profiles predict survival of lymphoma patients after chemotherpy
11. Jefferson scientist sees drug profiles and tailor-made therapies as ways to beat HIV resistance

Post Your Comments:

(Date:7/23/2019)... ... July 23, 2019 , ... Shady Grove Fertility (SGF) ... grand opening of its newest full-service fertility and in vitro fertilization (IVF) program in ... full-service location offers access to two leading, board certified reproductive endocrinologists, a state-of-the-art laboratory, ...
(Date:7/21/2019)... ... ... Surgical facelifts might be the gold standard for lifting facial skin and ... needs surgery, according to cosmetic surgeon Dr. Richard E. Buckley, medical director of MilfordMD ... who can’t tolerate the downtime associated with a surgical facelift, don’t want surgery or ...
(Date:7/18/2019)... ... July 18, 2019 , ... ... officials in Congress about new bills to protect patients from unexpected out-of-network medical ... People from Surprise Medical Bills Act ( H.R. 3502 ), introduced in the ...
(Date:7/18/2019)... ... July 18, 2019 , ... For the fourth ... Atlanta, Magazine’s list of “Top Doctors” issue. Deutsch is a double-board-certified plastic and, ... With specialized training from MD Anderson Cancer Center and Albert Einstein, Montefiore Medical ...
(Date:7/17/2019)... ... 17, 2019 , ... The FDA has cleared the "truSculpt® flex" ... to eight body areas simultaneously. Dr. Dennis Dass says the truSculpt® flex ... than previous muscle toning devices or conventional exercise. , “The truSculpt® flex is FDA-cleared ...
Breaking Medicine News(10 mins):
(Date:7/23/2019)... (PRWEB) , ... July 23, 2019 , ... ... its sixth physical rehabilitation hospital in the ever-growing Liberty Township (N. Cincinnati), Ohio ... acres, just north of Cincinnati, Ohio. The hospital site is located at the ...
(Date:7/23/2019)... ... July 23, 2019 , ... Breathe Life , a ... Hill , Partner at Diagram Ventures , has joined its board of directors. ... building and scaling early-stage technology businesses to the Breathe Life board at a time ...
(Date:7/23/2019)... ... July 23, 2019 , ... ... needs in the field of urology, today announced that Samuel Dakil, MD, Norman ... Excellence. The designation recognizes that Dr. Dakil has achieved a high level of ...
Breaking Medicine Technology:
Cached News: