HOME >> MEDICINE >> NEWS
Comprehensive gene profiles hold promise for improving outcome of pediatric leukemia

(MEMPHIS, TENN.--October 31 , 2003) Investigators at St. Jude Children's Research Hospital have identified the genetic fingerprints of the major subtypes of pediatric acute lymphoblastic leukemia (ALL), the most commonly treated pediatric cancer. The achievement promises to enhance the ability of physicians to more accurately diagnose ALL, improve their ability to accurately monitor a patient's response to therapy, and eventually, develop more effective and less-toxic drugs to treat this cancer.

The findings will also provide an invaluable resource for exploring the biological events that turn normal white blood cells into leukemic cells, according to James Downing, M.D., chair of the St. Jude department of Pathology. Downing is senior author of a report on this work, which appears in the October issue of Blood.

"Our ability to genetically fingerprint the different subtypes of ALL is extremely important," Downing said. "The only way to know how aggressively to treat a specific patient is to know which subtype of ALL the child has, since each subtype has a different prognosis."

The current work by the St. Jude team builds on work they previously published in 2002. In that study, the team used a single gene chip to identify the known subtypes of ALL. The current study used much higher density gene chips, which provided nearly complete coverage of the human genome. As a result, almost 60 percent of the ALL genes identified in the present study are new.

Pediatric ALL is one of the great success stories of modern cancer therapies, with overall event-free survival rates approaching 80 percent, according to Downing. Part of this success is due to the realization by researchers that there are different subtypes of ALL, each of which must be treated with a different level of intensity. This so-called risk-adapted therapy depends on accurately defining a patient's relative risk of relapse following treatment, and doing so before treatment begins. <
'"/>

Contact: Bonnie Cameron
bonnie.cameron@stjude.org
901-495-4815
St. Jude Children's Research Hospital
31-Oct-2003


Page: 1 2 3

Related medicine news :

1. The National Comprehensive Cancer Network recognizes National Cancer Fatigue Awareness Day
2. Cedars-Sinai Comprehensive Cancer Center adds new dimension in radiation treatment
3. Comprehensive pituitary center at Cedars-Sinai brings together under one roof medical, surgical, research and other components
4. American Psychiatric Association Plans First Comprehensive Guidelines For HIV/AIDS Treatment
5. Comprehensive Heart Failure Program At Cedars-Sinai Medical Center
6. Comprehensive Effort Needed To Prevent And Treat Traumatic Injuries
7. Most Comprehensive Study Of Its Kind Shows Common Asthma Medications Dont Cause Behavioral Problems In Children, According To The Journal Pediatrics
8. Research study profiles indoor tanners
9. Diabetic women on hormone replacement therapy have better glycemic and lipid profiles
10. Gene expression profiles predict survival of lymphoma patients after chemotherpy
11. Jefferson scientist sees drug profiles and tailor-made therapies as ways to beat HIV resistance

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2020)... ... March 30, 2020 , ... Frontline Public Safety Solutions is ... an effort to keep frontline officers and the public safe in the face ... while minimizing direct contact. They are also freeing up 911 lines for genuine ...
(Date:3/28/2020)... ... March 27, 2020 , ... Ahead of National Infertility ... of “The Fertility Journey.” This campaign will serve as a guide, showcasing the ... health options. , One in 6 couples experiences trouble with fertility. From ...
(Date:3/27/2020)... Calif. (PRWEB) , ... March 27, 2020 , ... ... focused on addressing unmet needs in the field of urology, today announced that ... as a UroLift® Center of Excellence. The designation recognizes that Dr. Wadhwa has ...
(Date:3/22/2020)... ... , ... “At a time when the public is being told not to ... First Stop Health Telemedicine program is a valuable resource to fall back ... is a valuable tool that can help Americans in their fight to stay healthy,” ...
(Date:3/20/2020)... ... March 21, 2020 , ... The Healthcare Compliance Symposium ... day of live discussion and learning online. Experts will provide helpful insight on ... the role of boards, fraud, waste and abuse, and privacy and security laws ...
Breaking Medicine News(10 mins):
(Date:3/27/2020)... ... March 27, 2020 , ... PTS Diagnostics, a U.S.-based manufacturer ... as President and Chief Executive Officer. , Mr. Chapman brings 20 years of ... ARKRAY USA, Inc. He joins PTS Diagnostics with an accomplished track record regarding ...
(Date:3/22/2020)... ... March 21, 2020 , ... Since 1988, Gwatney dealerships have strived ... concerns heighten over the spread of COVID-19, Gwatney Mazda is pleased to announce two ... needs of the Memphis community. , The dealership’s new Home Test Drives and ...
(Date:3/20/2020)... ... 20, 2020 , ... Users who have tested positive for COVID-19 can anonymously ... of detailed location information, such as a specific building on campus or a local ... the virus. The app will also help people to more easily recall where they’ve ...
Breaking Medicine Technology:
Cached News: