HOME >> MEDICINE >> NEWS
Computational tool predicts how drugs work in cells, advancing efforts to design better medicines

(Boston) -- The ability to select and develop compounds that act on specific cellular targets has just gained a computational ally -- a mathematical algorithm that predicts the precise effects a given compound will have on a cell's molecular components or chemical processes. Using this tool, drug developers can design compounds that will act on only desired gene and protein targets, eliciting therapeutic responses free of unwanted side effects.

The research, which appears in the March 4 issue of Nature Biotechnology, reports on collaborative work by a team of biomedical engineers and chemists at Boston University. The team was led by Tim Gardner, an assistant professor in the College of Engineering's Department of Biomedical Engineering (BME) and its Center for BioDynamics, and James Collins, a professor in BME and co-director of the Center for BioDynamics, and done in collaboration with Scott Schaus and Sean Elliott, assistant professors in BU's Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD).

Although drug development is an active field of research, there have been few ways to predict optimal drug design. The molecular targets of many drug candidates are unknown and are often difficult to tease out from among the thousands of gene products found in a typical organism. This "blindness" in the welter of potential cellular targets means that the process of designing therapeutic drugs is neither precise nor efficient.

The BU research team sought to bring precision and efficiency to this discovery process. The team used a combination of computational and experimental methods to build and verify their tool, first using a reverse-engineering approach to decipher the multitude of regulatory networks operating among genes in a simple organism, then testing the ability of the resulting network models to predict gene and pathway targets for a variety of drug treatments. Finally, they used the
'"/>

Contact: Ann Marie Menting
amenting@bu.edu
617-358-1240
Boston University
8-Mar-2005


Page: 1 2

Related medicine news :

1. Computational innovation predicts how patients will respond to drug treatments
2. New evaluation tool reliably predicts recovery from coma
3. New scale predicts recovery of consciousness from coma after brain injury
4. Depression predicts heart rhythm abnormalities in heart attack patients
5. A shallow hip socket predicts osteoarthritis of the hip
6. Molecule predicts colon cancer patient survival
7. Substance in urine predicts development of preeclampsia
8. Blood protein predicts risk of heart attack
9. Molecular test predicts risk of breast cancer recurrence and who will benefit from chemotherapy
10. New molecular classification of breast cancer predicts response to chemotherapy
11. Family history predicts young womens risk of stroke

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/17/2019)... ... , ... Knotty Roller, the affordable all-in-one muscle recovery system with six tools ... than $20,000 in only eleven hours after launching on Kickstarter . , “We’re ... enjoy the ease of use and versatility of our product,” said Knotty Roller CEO ...
(Date:10/17/2019)... ... 17, 2019 , ... A clinical article reviewing the long-term performance of the ... at Plastic Surgery - The Meeting 2019 in San Diego last month. The article, ... by Larry S. Nichter, M.D., Robert A. Hardesty, M.D., and Gregg M. Anigian, M.D., ...
(Date:10/15/2019)... ... , ... Khalieghya Dandie-Evans, a liver transplant recipient from Richmond, Calif. was chosen ... float in the 131st Rose Parade® on New Year’s Day. She will represent the ... Nevada, the organization’s service area. , Khalieghya, 17, grew up believing it was “normal” ...
(Date:10/15/2019)... CHURCH, Va. (PRWEB) , ... October 15, 2019 ... ... Products:, Complying with FDA’s Most Recent IFU Guidance , **An FDAnews Webinar**, Tuesday, ... the recent Instructions for Use (IFU) guidance have on new drug applications and ...
(Date:10/15/2019)... ... ... Genomenon® announced today at the American Society of Human Genetics ... Mastermind® Genomic Search Engine into the SOPHiA Platform and the Alamut ... clinical researchers performing genomic analysis worldwide. , The SOPHiA Platform is the ...
Breaking Medicine News(10 mins):
(Date:10/15/2019)... FORESIDE, Maine (PRWEB) , ... ... ... Standards1 releases VALIDATE® LP2 linearity and calibration verification kit, for Roche cobas® ... A (Apo-A1) and Apolipoprotein B (Apo-B). Each VALIDATE® LP2 kit, liquid, ...
(Date:10/11/2019)... ... October 11, 2019 , ... Five New York fitness studios have teamed up to create ... opportunity to tour and sample a variety of the top group exercise classes offered on ... produced by Club Pilates on W. 57th St., the Hell’s Kitchen Sweat Crawl will feature ...
(Date:10/10/2019)... ... October 10, 2019 , ... Ovation Fertility is once ... of reproductive medicine, with six abstracts accepted for poster presentations at the ASRM ... October 12-16, 2019, in Philadelphia. , “Ovation will have a prominent presence in ...
Breaking Medicine Technology:
Cached News: