Connecticut researchers receive national award

Develop unusually powerful oral antibiotic

Two Connecticut chemists and their Croatian colleagues will be honored on August 20 by the worlds largest scientific society for discovering a new and unusual kind of antibiotic. As a team, Gene Michael Bright, Arthur E. Girard, Slobodan Djokic and Gabrijela Kobrehel will be designated one of 12 Heroes of Chemistry by the American Chemical Society at its 220th national meeting, in Washington, D.C.

"If theres one word to summarize my work with azithromycin, its serendipity," said Bright, a synthetic organic chemist at Pfizer Inc.s central research division. The antibiotic kills a broad spectrum of microbes -- from haemophilus and respiratory infections to chlamydia, which is generally transmitted sexually but can also infect the eye, causing blindness in thousands of Third World children.

"Azithromycin is the only antibiotic that actually leaves the bloodstream and accumulates in the tissues at the site of infection. Six pills can give two weeks of therapy," the research advisor explained. "None of this was part of the original concept. This is where I really have to give credit to such bright teammates."

Slobodan Djokic, research director at Pliva, a Croatian pharmaceutical company, made the drugs original version in 1982 with Pliva colleague Gabrijela Kobrehel. Brights research team at Pfizer spotted their intriguing patent and remade the molecule for testing in mice. The results were exciting, but the original drug did not work in oral form.

Eight months later, Bright discovered that a small structural change turned the molecule into a powerful oral -- and commercially viable -- antibiotic. Pfizer applied for a U.S. patent, not knowing that Plivas Djokic had made an identical discovery. Patents were mistakenly issued to both, and the two companies decided to partner to develop what later became azithromycin. Animal studies conducted by Pfizer pharmacologist Arthur Girard confirmed the

Contact: Christina Curtin
American Chemical Society

Page: 1 2

Related medicine news :

1. Scientists meet in Connecticut to discuss research findings
2. Indiana University researchers closer to helping hearing-impaired using stem cells
3. Protein that helps skin cancer spread identified by Stanford researchers
4. US life expectancy about to decline, researchers say
5. Gene for age-related macular degeneration discovered by Yale researchers
6. Dartmouth researchers find where musical memories are stored in the brain
7. Columbia researchers receive $3 million to combat genetic killer of infants & toddlers
8. US cancer researchers launch first American-Israeli cancer conference
9. USC dental researchers develop first test for predicting cavities in children
10. Young blood revives aging muscles, Stanford researchers find
11. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find

Post Your Comments:

(Date:7/4/2020)... ... July 03, 2020 , ... MemoryCare.com ... has announced the Best Memory Care Facilities in Charleston, South Carolina. The guide ... and amenities. , According to the Alzheimer’s Association , 5.6 million ...
(Date:7/2/2020)... ... 2020 , ... Dr. Christine Blaine has earned a stellar reputation ... located in Staten Island, Huntington and NYC, NY. Her former Manhattan clinic, located ... at The Parlor NYC at 160 Madison Avenue. Blaine Plastic Surgery will ...
(Date:7/2/2020)... ... , ... Allegheny Health Network (AHN) today announced that John S. Lee, MD, ... Dr. Lee succeeds Robert White, MD, who announced his plans for retirement earlier ... to help support a seamless transition. , Dr. Lee joins AHN from Edward-Elmhurst Healthcare, ...
(Date:7/1/2020)... ... , ... Dexur’s analysis of Medicare claims of hospitals within a ... Hospital , and Sky Ridge Medical Center had the best value ... tracks a patient’s episode of care from the date of admission for 90 days ...
(Date:7/1/2020)... ... 01, 2020 , ... Psilera Bioscience (“Psilera”), a ... announces its core executive team. The co-founders Drs. Jackie Salm and Chris Witowski ... as distinguished researchers within the cannabis industry. They are joined by pharmaceutical and ...
Breaking Medicine News(10 mins):
(Date:6/28/2020)... , ... June 28, 2020 , ... ... health. New studies substantiate the effectiveness of oral-care probiotics to maximize teeth ... While the science behind both is simple – utilizing naturally occurring positive ...
(Date:6/25/2020)... ... June 25, 2020 , ... ... Top App Developers & DesignRush following the launch a recent project. BeCurious Studio, ... platform for cancer survivors. , Commissioned by MyVictory Inc , the ...
(Date:6/25/2020)... ... June 25, 2020 , ... Drs. Gregory Toback and ... within the Periodontics category. As specialists, this team of periodontists offers ... RI. Laser gum disease therapy, minimally invasive gum recession treatment, and life-changing dental ...
Breaking Medicine Technology:
Cached News: