HOME >> MEDICINE >> NEWS
Controversial drug shown to act on brain protein to cut alcohol use

A naturally occurring hallucinogen advocated by some clinicians as a potent anti-addiction drug has been rigorously studied for the first time, confirming its ability to block alcohol craving in rodents, and clarifying how it works in the brain. The new research findings about the drug Ibogaine open the way for development of other drugs to reverse addiction without Ibogaine's side effects, potentially adding to the small arsenal of drugs that effectively combat addiction.

Derived from a West African shrub, Ibogaine has been championed for years by a cadre of clinicians and drug treatment advocates impressed with its ability to reverse withdrawal symptoms and craving for alcohol and various drugs of abuse. It has been used outside of the U.S. to treat addiction by American and other clinicians. But its side effects, including hallucinations, which made it popular in the 1960s drug culture, and evidence of toxicity to certain nerve cells in rodent studies have discouraged careful studies of its clinical potential against drug and alcohol addiction. The FDA has not approved use of Ibogaine in the U.S.

Scientists at UCSF's Ernest Gallo Clinic and Research Center have now shown definitively in experiments with mice and rats that Ibogaine does reduce alcohol consumption, and they have determined that it does so by increasing the level of a brain protein known as glial cell line-derived neurotrophic factor, or GDNF. In a separate study, they demonstrated that GDNF by itself decreases alcohol consumption.

The research is being published in the January 19 issue of The Journal of Neuroscience.

"By identifying the brain protein that Ibogaine regulates to reduce alcohol consumption in rats, we have established a link between GDNF and reversal of addiction -- knowledge of a molecular mechanism that should allow development of a new class of drugs to treat addiction without Ibogaine's side effects," said Dorit Ron, PhD, UCSF associate professor of
'"/>

Contact: Wallace Ravven
wravven@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
18-Jan-2005


Page: 1 2 3

Related medicine news :

1. Controversial Atkins Diet may be beneficial for people with epilepsy
2. Controversial performance enhancer "andro" affects brains as well as brawn, say UMass researchers
3. Cartilage repair techniques shown to restore patient mobility and reduce pain
4. Sprinklers shown effective in slowing dorm fires
5. HPV vaccine shown effective at reducing cancer-causing infections
6. HPV vaccine shown to substantially reduce cervical cancer
7. New research results: Heart jacket shown to be effective
8. Pioglitazone shown to reverse thickening of carotid artery wall
9. Isolated soy protein shown to benefit type 2 diabetics, study indicates
10. Pioglitazone HCI shown to lower blood pressure in hypertensive patients with type 2 diabetes
11. Increased risk of cardiovascular disease shown in PCOS patients

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Controversial drug shown act brain protein cut alcohol use

(Date:5/22/2015)... Pa. (PRWEB) May 22, 2015 Omar ... been selected to participate in the 2015 Congress of ... is described as a gathering of “America’s highest achieving ... new areas of healthcare, set new goals and learn ... include a live surgery, during which we can ask ...
(Date:5/22/2015)... PITTSBURGH, Pa (PRWEB) May 22, 2015 ... Network (AHN) today announced a new partnership to ... program for the region. The initiative includes a new ... BodyStage live demonstration theater, and a new traveling ... in the fall of 2015. , Designed to ...
(Date:5/22/2015)... California (PRWEB) May 22, 2015 Coco Libre, ... set a RecordSetter.com World Record at the 104th running of ... coconut water ice luge served 315 people in one hour—one ... to Breakers race is so true to the heart of ... felt bringing an ice luge to the finish line only ...
(Date:5/22/2015)... Medivo, Inc., a leader in lab data analytics, ... in ‘Baby Boomers’ Screened for HCV Following the 2012 CDC ... at Digestive Disease Week, May 16-19, 2015. , The ... members Carol Smyth, MB; Jason Bhan, MD; Tatiana Sorokina, MSc; ... Nancy Reau, MD from the University of Chicago, Chicago, IL. ...
(Date:5/22/2015)... Ticket Down is a reputable source for ... Eastern Conference Finals Tickets . All seating for the ... the ticket listing. , For the first time in ... of the Eastern Conference. One of the original franchises in ... and downs over the years, but the excitement level for ...
Breaking Medicine News(10 mins):Health News:Milton Hershey School Student Chosen for Congress of Future Medical Leaders 2Health News:Carnegie Science Center, Allegheny Health Network Partner to Create BodyTech 2Health News:Carnegie Science Center, Allegheny Health Network Partner to Create BodyTech 3Health News:Carnegie Science Center, Allegheny Health Network Partner to Create BodyTech 4Health News:Coco Libre Ice Luge Sets New World Record at Bay to Breakers 2Health News:Medivo Study Finds HCV Positivity Rates are 250% Higher Among Baby Boomers 2Health News:Cheap Lightning vs Rangers NHL Eastern Conference Finals Tickets: Ticket Down Slashes Ticket Prices on New York Rangers vs Tampa Bay Lightning Eastern Conference Playoffs 2Health News:Cheap Lightning vs Rangers NHL Eastern Conference Finals Tickets: Ticket Down Slashes Ticket Prices on New York Rangers vs Tampa Bay Lightning Eastern Conference Playoffs 3
(Date:5/21/2015)... May 21, 2015 Research ... addition of the "North American Active Wound ... Application (Surgical Wound, & Ulcer), by End-User (In-Patient, ... report to their offering. ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... is estimated to grow at a CAGR of ...
(Date:5/21/2015)... 2015 Research and ... addition of the "Arthroscopy Devices Markets ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,The purpose of this ... world market for Arthroscopy Devices. The report ... the market for these products. , ,Product ...
(Date:5/21/2015)... CITY, Calif. , May 21, 2015  Cardica, Inc. ... 2015, new employee Greg Watson , the company,s vice ... shares of the company,s common stock, at a per share ... 20, 2015. The stock option was granted pursuant to Cardica, ... of directors in May 2015 under Rule 5653(c)(4) of the ...
Breaking Medicine Technology:North American Active Wound Care Market 2015-2019 with Smith and Nephew, Molyncke HealthCare & ConvaTec Dominating 2Analysing Arthroscopy Devices Markets Worldwide 2014-2020 2Analysing Arthroscopy Devices Markets Worldwide 2014-2020 3Cardica Announces New Employment Inducement Grant 2
Cached News: