To achieve cooling, the body temperature of babies in the trial was lowered by 3-4 degrees for 72 hours after birth using a water-filled cap.
The research was undertaken in hospitals in North America, New Zealand and the UK, and the UK arm of the trial was carried out in University College London Hospital, the University of Bristol at St Michael's and Southmead Hospitals, and Imperial College London at Hammersmith Hospital.
Babies were recruited if there was evidence that the infant had received an inadequate supply of oxygen to the brain during delivery, and when electrical activity from the brain indicated a high risk of brain injury.
The trial, which was supported by Olympic Medical from Seattle, USA indicates that, for some babies, cooling can significantly reduce brain damage. "This demonstrates for the first time that treatment may be possible for babies who suffer oxygen deprivation at birth", comments Professor Marianne Thoresen from Bristol University. Most of the English babies were treated in the Bristol hospitals.
It was discovered some years ago that when the brain is starved of oxygen at birth damage does not occur immediately; instead, as Professor John Wyatt of University College London points out, "a chemical cascade is triggered leading to brain damage hours or days afterwards".
The cooling study results from a long series of studies begun a decade ago when the UK researchers started to work on the problem together with a group from the University of Auckland in New Zealand. In experiments they found that cooling prevented the chemical cascade from causing permanent brain damage, and developed the discovery to the point where the treatment could be tested in babies.
"The success of this long
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Contact: Cherry Lewis
cherry.lewis@bristol.ac.uk
44-1-17-928-8086
University of Bristol
27-Jan-2005