HOME >> MEDICINE >> NEWS
Cord blood stem cells save children with Hurler's syndrome

DURHAM, N.C. -- Stem cells from a newborn baby's umbilical cord blood can save the lives of children with Hurler's syndrome and can repair much of the progressive brain and organ damage that would otherwise be fatal to children, according to physicians at the Duke Comprehensive Cancer Center's Pediatric Blood and Marrow Transplant Program.

Children with this rare metabolic disease die by the age of 6 because they are missing an important enzyme, alpha-L-iduronidase, which leads to progressive damage in the brain, heart, bones, cartilage, liver and corneas. Stem cells from cord blood provide the needed enzyme in the brain and the rest of the body, thus halting the disease and aiding repair in these organs and tissues, the Duke study showed.

In fact, survival was higher and complications lower among the Duke children who received cord blood than among children previously described in the medical literature who had received adult bone marrow, said Duke's Susan Staba, M.D., lead author of the study. Results of the study in 20 children with Hurler's Syndrome are published in the May 6, 2004, issue of the New England Journal of Medicine. The research was partially funded by the National Heart, Lung, and Blood Institute.

Bone marrow from adult donors can save some Hurler's patients, but an exact match cannot be found in time for more than 50 percent of children, and time is critical in treating these children, said the researchers. Moreover, adult bone marrow fails to engraft in 28 to 37 percent of Hurler's patients, meaning the donor bone marrow does not take hold and begin to grow in the patient.

As an alternative treatment, Duke physician Joanne Kurtzberg, M.D., director of the Pediatric Blood and Marrow Transplant Program at Duke and senior author of the paper, tested the ability of cord blood stem cells to provide the missing enzyme and thereby halt the progressive organ deterioration in these children. Stem cells in cord blood a
'"/>

Contact: Becky Levine
levin005@mc.duke.edu
919-684-4148
Duke University Medical Center
5-May-2004


Page: 1 2 3 4

Related medicine news :

1. A marker for new blood vessel formation in tumors
2. Acupuncture found to lower elevations in blood pressure
3. Diagnostic test for range of blood disorders on the horizon
4. Research suggests possible blood test for multiple sclerosis
5. Epstein-Barr virus protein crucial to its role in blood cancers
6. Simple blood test may help to predict cardiovascular risk in older women
7. Drug that hinders blood vessel growth under study in ovarian cancer
8. Laughter helps blood vessels function better
9. St. Johns wort amplifies effect of blood thinner Plavix
10. Latest findings on genetic blood disorder Cooleys Anemia
11. Can routine commercial cord blood banking be scientifically and ethically justified?

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/17/2019)... , ... September 17, 2019 , ... ... availability of the newly updated International Audit Protocol Consortium (IAPC) EHS audit protocol ... protocols to understand the scope of their EHS regulatory obligations and rapidly collect, ...
(Date:9/14/2019)... ... September 13, 2019 , ... ... studies on the detection and treatment of infectious diseases at its annual ... studies were noninvasive detection of residual HIV infected cell persistence and the ...
(Date:9/11/2019)... , ... September 11, 2019 , ... A September 2 ... had undergone weight loss surgery were significantly less likely to suffer heart attacks, strokes, ... not undergo bariatric surgery. Los Angeles-based weight loss surgery specialists Dr. Feiz and Associates ...
(Date:9/11/2019)... ... , ... Autopsies don’t lie. They report the causes of death as ... harms the heart. It increases risks of heart attack and death. Autopsies ... damage occurs. , An August 1, 2019 article in U.S. News ...
(Date:9/11/2019)... (PRWEB) , ... September 10, 2019 , ... ... to the team. Dr. Hesano is an understanding, caring and highly skilled Obstetrician/Gynecologist. ... high-risk obstetrical medicine. Dr. Hesano strives to ensure that each visit is comfortable, ...
Breaking Medicine News(10 mins):
(Date:9/17/2019)... Calif. (PRWEB) , ... September 17, 2019 , ... Summer is a time for barbecues, ... is good for our teeth and gums. Dr. Douglas Ng, family dentist in San ... weather is the time for ice cream, and popsicles and ice-filled cold drinks to go ...
(Date:9/14/2019)... ... 13, 2019 , ... Corey Stern , a partner at Levy Konigsberg, ... Archibald over at least 3 decades while employed by Rockefeller University Hospital (“RUH”). ... Court - Southern District of New York, No. 1:19-cv-01403), the first case filed against ...
(Date:9/14/2019)... ... September 14, 2019 , ... On ... with peritoneal mesothelioma, a jury in Middlesex County found Johnson & Johnson liable ... alleging their mesotheliomas were caused by asbestos-containing J&J talc products. , ...
Breaking Medicine Technology:
Cached News: