HOME >> MEDICINE >> NEWS
Coupling of brain proteins may prompt new treatments for schizophrenia, addiction

Researchers at the University of Toronto, the Centre for Addiction and Mental Health (CAMH) and the Hospital for Sick Children (HSC) have discovered a cellular communication method in the brain that could lead to improved treatments for schizophrenia and addiction.

Many of the symptoms associated with schizophrenia and addiction are caused by either too much or too little dopamine and GABA, chemicals in the brain that help regulate learning, memory, emotion and cognition. In a study published in the Jan. 20 edition of the journal Nature, researchers demonstrate how proteins can modify each other's function - including the ability of neurons to accept or reject dopamine and other neurochemicals - by binding to each other.

"What we found is a previously unknown method of signal transduction between two structurally different neurotransmitter receptor systems, that is, the direct physical coupling of these proteins," says senior author Dr. Hyman Niznik, associate professor of psychiatry and pharmacology at U of T and section head, laboratory and molecular neurobiology at CAMH. "This may provide us with a new therapeutic window on how to restore normal cellular function in diseases like schizophrenia with the right medication that can either block this interaction or make it happen." Brain cells communicate with each other via neurotransmitters - natural chemicals that interact with proteins, or receptors, on adjacent neurons. There are many different types of receptors in the brain, some of which respond only to dopamine and some only to the neurotransmitter GABA [g-aminobutyric acid]. Of the many dopamine receptors, two - D1 and D5 - are very similar and respond to the same drugs. Many of the negative symptoms of schizophrenia and addiction are regulated by D1-like receptors.

Niznik and his team of researchers demonstrated that dopamine D5 receptors can directly modify the function of GABA receptors by directly binding to them and forming
'"/>

Contact: Megan Easton
megan.easton@utoronto.ca
416-978-5948
University of Toronto
18-Jan-2000


Page: 1 2

Related medicine news :

1. Some brain cells change channels to fine-tune the message
2. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
3. Can you read my mind? W.M. Keck Foundation funds innovative brain research at Carnegie Mellon
4. Scientist works on innovative treatments for brain tumors
5. Mechanism of RNA recoding: New twists in brain protein production
6. Does the college experience damage your brain?
7. Dartmouth researchers find where musical memories are stored in the brain
8. Common anesthetics appear safe for developing fetal brain
9. Breakthrough in medical research: New chemotherapy gives hope to brain tumour patients
10. New scale predicts recovery of consciousness from coma after brain injury
11. Study: Two brain systems regulate how we call for help

Post Your Comments:
(Date:8/23/2014)... Pixel Film Studios, a leader of Final Cut ... ProIntro Vol.3, a customizable title tool for FCPX ... by dragging ProIntro Vol.3 in their timeline" says Christina Austin, ... time saver and i think our users will agree" , ... titles made with Final Cut Pro X users in mind. ...
(Date:8/23/2014)... August 23, 2014 Teen drug and ... It’s no different in Wilmington, NC. Substance abuse can ... falling victim to drug and alcohol dependency in higher ... looking to overcome substance abuse, but don’t know where ... treatment facility can be a challenge because most treatment ...
(Date:8/22/2014)... 23, 2014 The IT manager of ... hosting for several years. He has recently announced that ... hosting suppliers in 2014. , GoDaddy is a popular ... features and great hosting solutions at affordable rates. It ... for shared hosting plans depend on the length of ...
(Date:8/22/2014)... Park City, UT (PRWEB) August 22, 2014 ... Solution, published a new guide on Account-Based Health Plans. ... health plans (ABHPs) as a strategy to lower the ... the different types of medical spending accounts, however, can ... easy-to-understand comparison chart to learn the four main types ...
(Date:8/22/2014)... Recently, UWDress.com, a leading online supplier of wedding dresses and ... empire bridesmaid dresses to its product line. In ... for these high quality items. All of them are now ... off. , The company’s new items can definitely add ... its website. It is true that all its products are ...
Breaking Medicine News(10 mins):Health News:A new plugin was announced today, ProIntro Vol.3 from Pixel Film Studios for Final Cut Pro X 2Health News:Troubled Teens Wilmington Helpline Guides Adolescents to the Path of Recovery 2Health News:Discounted Empire Bridesmaid Dresses Online At UWDress.com 2
(Date:8/21/2014)... , Aug. 21, 2014  Vermillion, Inc. (NASDAQ: ... gynecologic cancers and women,s health, has appointed Holly ... Managed Markets. Ms. Bauzon has a proven ... payer coverage for laboratory services companies. She has more ... PerkinElmer, Inc., where she held the position of Director, ...
(Date:8/21/2014)... AUSTIN, Texas , Aug. 21, 2014 /PRNewswire/ ... IT services company, announced today that it has ... Records (EMR) solution for Plastic Surgery and Dermatology ... provide even more value to healthcare practices using ... CEO of eRelevance Corporation. "Using information from the ...
(Date:8/21/2014)... , Aug. 21, 2014  Publicis Groupe customer ... , Managing Partner and Healthcare Industry Group Leader, has ... which recognizes the most inspiring people in the life-sciences ... in research and development, marketing, technology, creativity, strategy and ... 2006 as a partner in its leading Rosetta Consulting ...
Breaking Medicine Technology:Vermillion Appoints Holly B. Bauzon as VP of Sales and Managed Markets 2eRelevance Corporation Integrates with Nextech Electronic Medical Records 2Shannon Hartley Shines in PharmaVOICE 100 2
Cached News: