HOME >> MEDICINE >> NEWS
Coupling of brain proteins may prompt new treatments for schizophrenia, addiction

Researchers at the University of Toronto, the Centre for Addiction and Mental Health (CAMH) and the Hospital for Sick Children (HSC) have discovered a cellular communication method in the brain that could lead to improved treatments for schizophrenia and addiction.

Many of the symptoms associated with schizophrenia and addiction are caused by either too much or too little dopamine and GABA, chemicals in the brain that help regulate learning, memory, emotion and cognition. In a study published in the Jan. 20 edition of the journal Nature, researchers demonstrate how proteins can modify each other's function - including the ability of neurons to accept or reject dopamine and other neurochemicals - by binding to each other.

"What we found is a previously unknown method of signal transduction between two structurally different neurotransmitter receptor systems, that is, the direct physical coupling of these proteins," says senior author Dr. Hyman Niznik, associate professor of psychiatry and pharmacology at U of T and section head, laboratory and molecular neurobiology at CAMH. "This may provide us with a new therapeutic window on how to restore normal cellular function in diseases like schizophrenia with the right medication that can either block this interaction or make it happen." Brain cells communicate with each other via neurotransmitters - natural chemicals that interact with proteins, or receptors, on adjacent neurons. There are many different types of receptors in the brain, some of which respond only to dopamine and some only to the neurotransmitter GABA [g-aminobutyric acid]. Of the many dopamine receptors, two - D1 and D5 - are very similar and respond to the same drugs. Many of the negative symptoms of schizophrenia and addiction are regulated by D1-like receptors.

Niznik and his team of researchers demonstrated that dopamine D5 receptors can directly modify the function of GABA receptors by directly binding to them and forming
'"/>

Contact: Megan Easton
megan.easton@utoronto.ca
416-978-5948
University of Toronto
18-Jan-2000


Page: 1 2

Related medicine news :

1. Some brain cells change channels to fine-tune the message
2. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
3. Can you read my mind? W.M. Keck Foundation funds innovative brain research at Carnegie Mellon
4. Scientist works on innovative treatments for brain tumors
5. Mechanism of RNA recoding: New twists in brain protein production
6. Does the college experience damage your brain?
7. Dartmouth researchers find where musical memories are stored in the brain
8. Common anesthetics appear safe for developing fetal brain
9. Breakthrough in medical research: New chemotherapy gives hope to brain tumour patients
10. New scale predicts recovery of consciousness from coma after brain injury
11. Study: Two brain systems regulate how we call for help

Post Your Comments:
(Date:11/24/2014)... Alberta (PRWEB) November 24, 2014 ... people each day. They break up families, ruin ... is new hope for those that suffer,” says ... scientific research is showing that our specialized nutritional ... Hardy will appear on “Mind Over Matter”, the ...
(Date:11/24/2014)... CA (PRWEB) November 24, 2014 SafeHandles™ ... episode of Innovations with Ed Begley Jr, airing via ... was created to provide a passive, non-invasive, replaceable, and ... how SafeHandles™ incorporates custom-fit shrinkable sleeves and adhesives to ... , “At the core of SafeHandles is the ...
(Date:11/24/2014)... Gersowitz Libo & Korek, P.C., a leading national ... recognition in the 2015 Edition of U.S. News-Best Lawyers list ... unique combination of quality law practice and breadth of legal ... and especially grateful to our clients whose continued support of ... said Jeff S. Korek, senior partner at Gersowitz Libo ...
(Date:11/24/2014)... "My friend was killed when a vehicle ... street in his motorized wheelchair," said an inventor from ... up with this idea so that people in wheelchairs ... the Safety Lites to make a wheelchair highly visible, ... ensures that motorists can see the wheelchair. This helps ...
(Date:11/23/2014)... well-known wedding dress manufacturer, has unveiled its new collection of ... offered at deeply discounted prices, up to 75 percent off. ... The main purpose of the promotion is to expand iFitDress.com’s ... ideal options for ladies who are eager to look charming ... mint cocktail dresses are very beautiful; they are made with ...
Breaking Medicine News(10 mins):Health News:Nutritional Mental Health Treatment Featured on Access Health Airing on Lifetime Television® 2Health News:Nutritional Mental Health Treatment Featured on Access Health Airing on Lifetime Television® 3Health News:New Episode of Innovations TV Series to Feature SafeHandles™ 2Health News:U.S. News-Best Lawyers “Best Law Firms” Names Gersowitz Libo & Korek P.C. a 2015 Tier 1 Ranking Firm 2Health News:Trendy Long Black Evening Gowns Now Provided By iFitDress.com 2
(Date:11/23/2014)...  Aurobindo Pharma USA is ... mg 100-count bottles to the consumer level. The product ... Empty capsules could result in missed dose(s) ... range from no effect, short term reduction in efficacy, ... seizures) that could be life-threatening. Aurobindo Pharma ...
(Date:11/22/2014)... MONMOUTH JUNCTION, N.J. , Nov. 21, 2014 ... immunotherapy company commercializing its European Union approved CytoSorb® ... countries worldwide, was awarded the Beacon of Light ... Annual Awards Celebration.  Dr. ... stated, "It is an honor to be recognized ...
(Date:11/22/2014)... , Nov. 21, 2014 Statistics released ... and drunk driving increase astronomically during the holidays, beginning ... in many cities. The data, ... Monitoring Systems as part of their annual ... paints a picture of high-risk drinking and increased rates ...
Breaking Medicine Technology:Aurobindo Pharma USA, Inc. Issues Voluntary Nationwide Recall of Northstar Label Gabapentin Capsules, USP 300 mg Due to Complaints of Empty Capsules 2CytoSorbents Wins Beacon of Light Award 2CytoSorbents Wins Beacon of Light Award 3CytoSorbents Wins Beacon of Light Award 4Alarming Stats Show Holiday Drinking an Issue for Many 2
Cached News: