HOME >> MEDICINE >> NEWS
Crystal Structure Of gp120 Reveals HIV In Action

NEW YORK, NY, 1998 -- In the long battle against AIDS, a philosophy of "know the enemy" has guided basic research. Specifically, investigators have sought a viral Achilles heel by dissecting the precise molecular choreography that unfolds as HIV penetrates the linchpin-like T cells of the immune system. Now, an unprecedented peek at that process -- a viral surface glycoprotein caught in the act of binding a CD4 T cell receptor -- graces the covers of both the June 18 issue of Nature and the June 19 issue of Science magazines.

The long-sought crystal structure of gp120 in action is a collaborative effort led by researchers from the Columbia University College of Physicians & Surgeons, and the Dana-Farber Cancer Institute. "The crystal structure tells us how the virus is able to bind to the receptor at the same time that it remains sufficiently changeable to avoid immune detection. There is the potential for the information to be used to design compounds that interfere and block that interaction," says Wayne Hendrickson, Ph.D., professor of biochemistry and molecular biophysics at Columbia University and a Howard Hughes Medical Institute Investigator. Adds Peter Kwong, Ph.D., associate research scientist at Columbia and lead author on the first Nature paper, "Knowing the structure down to the atomic details will provide valuable clues for vaccine design."

X-ray crystallography is a technique that passes X-rays through a crystal from many angles, determines their pattern of diffraction, and then assembles the data to reveal the crystal's 3-dimensional structure, or conformation. The technique was key in solving the structure of DNA in 1953 and, more recently, in discovering the structure of HIV protease, which led to development of protease inhibitors.

But X-ray crystallography requires crystallizing a compound, which was no small feat for gp120. "The mechanisms that HIV has to protect itself from
'"/>

Contact: Carolyn Conway
cc328@columbia.edu
212-305-3900
Columbia University Medical Center
17-Jun-1998


Page: 1 2 3

Related medicine news :

1. Crystal methamphetamine use increases HIV risk
2. Crystallographers meet in Los Angeles
3. Repeated Exposure To Cocaine Alters Brain Structure
4. Fertilization Protein Structure To AID in Leukemia Treatment
5. Livers From Children Are Going To Adults, University Of Pittsburgh Review Of National Data Reveals
6. Study Reveals Prominent Fears Of School-Age Children
7. Study Reveals Gender Affects Lung-Cancer Development
8. Study Of Women And Hearing Reveals Need For Routine Hearing Tests
9. Study Reveals Possible Link Between Osteoarthritis, Diet
10. Beta-Blockers Underused In Older Patients After Heart Attacks, Major Study Of 45,000 Patients 65 Years Or Older Reveals
11. Study Reveals Possible Clue For Racial Differences In Prevalence Of High Blood Pressure

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2017)... CITY, UTAH (PRWEB) , ... April 28, 2017 ... ... as Account Manager for the North East region. Côté has 20+ years of ... consulting. Prior to Phytomer, Côté worked with an array of high-end cosmetic brands, ...
(Date:4/28/2017)... , ... April 28, 2017 , ... ... and advanced nutraceutical supplements, through its Nova Skin Sciences division, recently announced ... benefits of a moisturizer with the power of an anti-aging concentrate. ...
(Date:4/28/2017)... ... 28, 2017 , ... Rob Lowe is a popular actor that has been ... to an educational purpose as the host of the “Informed” series. The program focuses ... recent episode, the series focuses on thyroid cancer. , Although thyroid cancer is an ...
(Date:4/28/2017)... ... 2017 , ... Christie Medical Holdings, Inc. , with its market-leading ... Medical Inc. , a leader in infusion therapy and pain management. , Intravenous ... percent of hospital patients receiving a peripheral IV catheter as part of their treatment ...
(Date:4/27/2017)... ... April 27, 2017 , ... The Incentive ... and Recognition: A Nudge Guide," a groundbreaking analysis of how behavioral economics can ... to apply immediately to IRR programs, the report highlights proven behavioral economics approaches ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... Mass. , April 20, 2017  RXi ... developing innovative therapeutics that address significant unmet medical ... data from the Company,s consumer product development program, ... at the Society for Investigative Dermatology (SID) 76 ... to advance and promote the sciences relevant to ...
(Date:4/20/2017)... Research and Markets has announced the addition of the ... Outlook, Growth Trends, Key Players, Competitive Strategies and Forecasts, 2014 ... ... US$ 7,167.6 Mn in 2015, and is expected to reach ... 5.6% from 2016 to 2024. The global ...
(Date:4/19/2017)... 2017 Cardiology devices segment is anticipated to reach ... The Cardiology Devices segment is likely to create absolute $ ... 2018 over 2017. By the end of 2027, Cardiology Devices ... US$ 700 Mn, expanding at a CAGR of 18.4% over ... Asia Pacific reprocessed medical devices market in ...
Breaking Medicine Technology:
Cached News: