HOME >> MEDICINE >> NEWS
Crystal Structure Of gp120 Reveals HIV In Action

NEW YORK, NY, 1998 -- In the long battle against AIDS, a philosophy of "know the enemy" has guided basic research. Specifically, investigators have sought a viral Achilles heel by dissecting the precise molecular choreography that unfolds as HIV penetrates the linchpin-like T cells of the immune system. Now, an unprecedented peek at that process -- a viral surface glycoprotein caught in the act of binding a CD4 T cell receptor -- graces the covers of both the June 18 issue of Nature and the June 19 issue of Science magazines.

The long-sought crystal structure of gp120 in action is a collaborative effort led by researchers from the Columbia University College of Physicians & Surgeons, and the Dana-Farber Cancer Institute. "The crystal structure tells us how the virus is able to bind to the receptor at the same time that it remains sufficiently changeable to avoid immune detection. There is the potential for the information to be used to design compounds that interfere and block that interaction," says Wayne Hendrickson, Ph.D., professor of biochemistry and molecular biophysics at Columbia University and a Howard Hughes Medical Institute Investigator. Adds Peter Kwong, Ph.D., associate research scientist at Columbia and lead author on the first Nature paper, "Knowing the structure down to the atomic details will provide valuable clues for vaccine design."

X-ray crystallography is a technique that passes X-rays through a crystal from many angles, determines their pattern of diffraction, and then assembles the data to reveal the crystal's 3-dimensional structure, or conformation. The technique was key in solving the structure of DNA in 1953 and, more recently, in discovering the structure of HIV protease, which led to development of protease inhibitors.

But X-ray crystallography requires crystallizing a compound, which was no small feat for gp120. "The mechanisms that HIV has to protect itself from
'"/>

Contact: Carolyn Conway
cc328@columbia.edu
212-305-3900
Columbia University Medical Center
17-Jun-1998


Page: 1 2 3

Related medicine news :

1. Crystal methamphetamine use increases HIV risk
2. Crystallographers meet in Los Angeles
3. Repeated Exposure To Cocaine Alters Brain Structure
4. Fertilization Protein Structure To AID in Leukemia Treatment
5. Livers From Children Are Going To Adults, University Of Pittsburgh Review Of National Data Reveals
6. Study Reveals Prominent Fears Of School-Age Children
7. Study Reveals Gender Affects Lung-Cancer Development
8. Study Of Women And Hearing Reveals Need For Routine Hearing Tests
9. Study Reveals Possible Link Between Osteoarthritis, Diet
10. Beta-Blockers Underused In Older Patients After Heart Attacks, Major Study Of 45,000 Patients 65 Years Or Older Reveals
11. Study Reveals Possible Clue For Racial Differences In Prevalence Of High Blood Pressure

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/19/2017)... ... August 19, 2017 , ... Praeclarus Press has launched ... illustrations show the diversity of the breastfeeding mothers, using bright colors and ... sizes. These illustrations are also available on tote bags, notepads, smartphone cases, clocks, ...
(Date:8/19/2017)... ... August 19, 2017 , ... Parker ... community of over 1,000 passionate employees, caregivers, volunteers, thought leaders, researchers, educators and ... changed ownership, it was time to refresh the carpeting with the goal of ...
(Date:8/19/2017)... ... 2017 , ... “Congratulations! It's A Boy! God’s Gift: A Story of Love”: ... God. “Congratulations! It's A Boy! God’s Gift: A Story of Love” is the creation ... York. , Published by Christian Faith Publishing, Dale Anthony and Rachael Anthony’s new book ...
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... More than ... Democratic Republic of Congo (DRC) thanks to an ambitious venture that conjoined the passions ... as the generous support of the Liberty community. These shoes will save lives from ...
(Date:8/18/2017)... , ... August 18, 2017 ... ... Quick International, LLC (“Quick”), a highly specialized asset-light logistics provider of complex ... into a definitive agreement to purchase Unitrans International Corporation, a division of ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... , Aug. 15, 2017  AOTI Inc. announced today that ... Therapy Inc., has recently opened a New York City Office in ... usage of its unique Topical Wound Oxygen (TWO 2 ) homecare ... the Accreditation Commission for Health Care (ACHC) under the company,s DMEPOS ... ...
(Date:8/8/2017)...   Second-quarter 2017 ... loss per share from continuing operations ... 16 percent to $110 million ... to $161 million Second-quarter ... operations increased 8 percent to $0.93 ...
(Date:8/7/2017)... 2017  Endo International plc (NASDAQ: ENDP ... virtually all known U.S. mesh product liability claims and ... known remaining U.S. claims at reasonable values. Under the ... fourth quarter of 2017 and continuing through the fourth ... 2017 results, the Company intends to increase its mesh ...
Breaking Medicine Technology:
Cached News: