HOME >> MEDICINE >> NEWS
Crystal Structure Of gp120 Reveals HIV In Action

NEW YORK, NY, 1998 -- In the long battle against AIDS, a philosophy of "know the enemy" has guided basic research. Specifically, investigators have sought a viral Achilles heel by dissecting the precise molecular choreography that unfolds as HIV penetrates the linchpin-like T cells of the immune system. Now, an unprecedented peek at that process -- a viral surface glycoprotein caught in the act of binding a CD4 T cell receptor -- graces the covers of both the June 18 issue of Nature and the June 19 issue of Science magazines.

The long-sought crystal structure of gp120 in action is a collaborative effort led by researchers from the Columbia University College of Physicians & Surgeons, and the Dana-Farber Cancer Institute. "The crystal structure tells us how the virus is able to bind to the receptor at the same time that it remains sufficiently changeable to avoid immune detection. There is the potential for the information to be used to design compounds that interfere and block that interaction," says Wayne Hendrickson, Ph.D., professor of biochemistry and molecular biophysics at Columbia University and a Howard Hughes Medical Institute Investigator. Adds Peter Kwong, Ph.D., associate research scientist at Columbia and lead author on the first Nature paper, "Knowing the structure down to the atomic details will provide valuable clues for vaccine design."

X-ray crystallography is a technique that passes X-rays through a crystal from many angles, determines their pattern of diffraction, and then assembles the data to reveal the crystal's 3-dimensional structure, or conformation. The technique was key in solving the structure of DNA in 1953 and, more recently, in discovering the structure of HIV protease, which led to development of protease inhibitors.

But X-ray crystallography requires crystallizing a compound, which was no small feat for gp120. "The mechanisms that HIV has to protect itself from
'"/>

Contact: Carolyn Conway
cc328@columbia.edu
212-305-3900
Columbia University Medical Center
17-Jun-1998


Page: 1 2 3

Related medicine news :

1. Crystal methamphetamine use increases HIV risk
2. Crystallographers meet in Los Angeles
3. Repeated Exposure To Cocaine Alters Brain Structure
4. Fertilization Protein Structure To AID in Leukemia Treatment
5. Livers From Children Are Going To Adults, University Of Pittsburgh Review Of National Data Reveals
6. Study Reveals Prominent Fears Of School-Age Children
7. Study Reveals Gender Affects Lung-Cancer Development
8. Study Of Women And Hearing Reveals Need For Routine Hearing Tests
9. Study Reveals Possible Link Between Osteoarthritis, Diet
10. Beta-Blockers Underused In Older Patients After Heart Attacks, Major Study Of 45,000 Patients 65 Years Or Older Reveals
11. Study Reveals Possible Clue For Racial Differences In Prevalence Of High Blood Pressure

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Crystal Structure Reveals HIV Action

(Date:8/28/2015)... ... August 28, 2015 , ... ... Position and Best Practices for Compliance, **Presented by FDAnews and GessNet**, Oct. ... by internationally renowned expert Fubin Wu, has been specifically designed to provide ...
(Date:8/28/2015)... ... August 28, 2015 , ... Saint Petersburg, FL ... with zero fat, carbs, sugar, gluten, lactose or caffeine in a convenient 2 ... 2015 SupplySide CPG Editor’s Choice Awards. , Five consumer packaged goods (CPG) products ...
(Date:8/28/2015)... (PRWEB) , ... August 28, 2015 , ... ... of the Veterans Award, honoring military veterans leading in business. Mr. Troy ... , The inaugural Nashville Business Journal's 2015 Veterans Awards will recognize ...
(Date:8/28/2015)... ... August 28, 2015 , ... Northridge dentists Dr. ... whitening. For just $199, patients can currently receive a one hour treatment of this ... procedures, but it includes a number of unique features that can turn teeth up ...
(Date:8/28/2015)... Raleigh, NC (PRWEB) , ... August 28, 2015 , ... ... mesothelioma will not be available for general use any time soon, according to educational ... MTG-201, a biologic therapy that received orphan drug designation for mesothelioma last week from ...
Breaking Medicine News(10 mins):Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 2Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 3Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 4Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 5Health News:Pocket Protein™ Named 2015 CPG Editor’s Choice Award Finalist by Informa’s SupplySide 2Health News:Pocket Protein™ Named 2015 CPG Editor’s Choice Award Finalist by Informa’s SupplySide 3Health News:MyGenetx Board Member Receives Veterans Award 2Health News:Northridge Dentists Dr. Elyson and Dr. Assili Now Offer a Special Promotion on Zoom Teeth Whitening 2Health News:Surviving Mesothelioma Puts New Orphan Drug into Perspective in New Article 2
(Date:8/27/2015)... ieCrowd™ today announced the achievement of ... the company,s supplemental oxygen delivery device, Smart Oxygen ... by ieCrowd,s subsidiary Smart Oxygen Solutions TM , ... oxygen based on level of activity.  The FDA ... Smart Oxygen device would require a series of ...
(Date:8/27/2015)... Lilly and Company (NYSE: LLY ) will attend ... 17, 2015. Sue Mahony , Ph.D., senior vice ... Gaynor , M.D., senior vice president of product development ... a fireside chat at 3:30 p.m., Eastern Daylight Time. ... available on the "Webcasts & Presentations" section of Lilly,s ...
(Date:8/27/2015)... Grow , the fastest-growing professional networking organization for women leaders ... World Congress & Business Exposition (CWCBExpo) in ... CWCBExpo in LA will take place September 16-18, 2015 at ... Los Angeles, CA , and is the ... industry. The Women Grow tracks at CWCBExpo ...
Breaking Medicine Technology:Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 2Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 3Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 4Lilly to Participate in Morgan Stanley Global Healthcare Conference 2Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 2Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 3Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 4
Cached News: