HOME >> MEDICINE >> NEWS
Crystal Structure Of gp120 Reveals HIV In Action

NEW YORK, NY, 1998 -- In the long battle against AIDS, a philosophy of "know the enemy" has guided basic research. Specifically, investigators have sought a viral Achilles heel by dissecting the precise molecular choreography that unfolds as HIV penetrates the linchpin-like T cells of the immune system. Now, an unprecedented peek at that process -- a viral surface glycoprotein caught in the act of binding a CD4 T cell receptor -- graces the covers of both the June 18 issue of Nature and the June 19 issue of Science magazines.

The long-sought crystal structure of gp120 in action is a collaborative effort led by researchers from the Columbia University College of Physicians & Surgeons, and the Dana-Farber Cancer Institute. "The crystal structure tells us how the virus is able to bind to the receptor at the same time that it remains sufficiently changeable to avoid immune detection. There is the potential for the information to be used to design compounds that interfere and block that interaction," says Wayne Hendrickson, Ph.D., professor of biochemistry and molecular biophysics at Columbia University and a Howard Hughes Medical Institute Investigator. Adds Peter Kwong, Ph.D., associate research scientist at Columbia and lead author on the first Nature paper, "Knowing the structure down to the atomic details will provide valuable clues for vaccine design."

X-ray crystallography is a technique that passes X-rays through a crystal from many angles, determines their pattern of diffraction, and then assembles the data to reveal the crystal's 3-dimensional structure, or conformation. The technique was key in solving the structure of DNA in 1953 and, more recently, in discovering the structure of HIV protease, which led to development of protease inhibitors.

But X-ray crystallography requires crystallizing a compound, which was no small feat for gp120. "The mechanisms that HIV has to protect itself from
'"/>

Contact: Carolyn Conway
cc328@columbia.edu
212-305-3900
Columbia University Medical Center
17-Jun-1998


Page: 1 2 3

Related medicine news :

1. Crystal methamphetamine use increases HIV risk
2. Crystallographers meet in Los Angeles
3. Repeated Exposure To Cocaine Alters Brain Structure
4. Fertilization Protein Structure To AID in Leukemia Treatment
5. Livers From Children Are Going To Adults, University Of Pittsburgh Review Of National Data Reveals
6. Study Reveals Prominent Fears Of School-Age Children
7. Study Reveals Gender Affects Lung-Cancer Development
8. Study Of Women And Hearing Reveals Need For Routine Hearing Tests
9. Study Reveals Possible Link Between Osteoarthritis, Diet
10. Beta-Blockers Underused In Older Patients After Heart Attacks, Major Study Of 45,000 Patients 65 Years Or Older Reveals
11. Study Reveals Possible Clue For Racial Differences In Prevalence Of High Blood Pressure

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Crystal Structure Reveals HIV Action

(Date:10/20/2014)... MA (PRWEB) October 20, 2014 ... sponsoring a booth at the American Foundation for Suicide ... 25th. The AFSP is a not-for-profit organization that hosts ... Net proceeds from these events are used to help ... but education and personal relationships as well. , ...
(Date:10/20/2014)... Zereana Jess-Huff, a 34-year-old mother, corporate executive and ... platform to think outside the bra. She doesn’t try to ... raise awareness about women’s other lady parts. , "We have ... the color pink and everybody knows what you’re talking about,” ... it has not been won when it comes to gynecologic ...
(Date:10/20/2014)... PA (PRWEB) October 20, 2014 ... Matthew Voicheck as Assistant Director of their ... role in managing the innovative turnkey drug sourcing, ... , Matthew brings over 12 years of industry ... joins Myoderm at the peak of their international ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 Final Cut Pro ... release of the Citrus theme for FCPX filmmakers . ... use to describe the Citrus theme” Says Christina Austin, CEO ... to look so professional.” , Citrus comes with all the ... the template are: four transitions for added style, a title ...
(Date:10/20/2014)... 20, 2014 Do you ever feel ... comes a wonderful app Metassessor for teachers, specialists and ... helped its client “Intervention Development LLC” to launch ... is designed for iOS 4.3 or later and is ... is optimized for iPhone 5. It is now available ...
Breaking Medicine News(10 mins):Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 2Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 3Health News:Ovarian Cancer Survivor Mrs. Maryland Urges Media to Think Outside the Bra 2Health News:Ovarian Cancer Survivor Mrs. Maryland Urges Media to Think Outside the Bra 3Health News:Myoderm Hires Matthew Voicheck to Lead Turnkey Drug Sourcing Service 2Health News:Today Pixel Film Studios Announced the Release of the Citrus theme for Final Cut Pro X 2Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 2Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 3
(Date:10/17/2014)... 2014   InnFocus, Inc ., reported on results of ... for up to 3 years with the InnFocus ... Chicago . The Summit ... meeting of the American Academy of Ophthalmology . The ... glaucoma patients in 6 countries by early 2015. ...
(Date:10/17/2014)... 2014  China Biologic Products, Inc. (NASDAQ: CBPO, ... integrated plasma-based biopharmaceutical company in China ... received approval from the China Food and Drug ... prothrombin complex concentrate ("PCC") at its Shandong Taibang ... factor production facility for Good Manufacturing Practices ("GMP") ...
(Date:10/17/2014)... DENVER , Oct. 17, 2014   ... DVA ), one of the nation,s largest and ... 150th DaVita University Academy – the company,s award-winning, ... teammates. Nearly 2,000 DaVita teammates from around the ... DaVita University Academy is a two-day ...
Breaking Medicine Technology:InnFocus Featured at the Ophthalmology Innovation Summit In Chicago 2China Biologic Receives Approval for Commercial Manufacturing of Human Prothrombin Complex Concentrate at Shandong Taibang Facility 2China Biologic Receives Approval for Commercial Manufacturing of Human Prothrombin Complex Concentrate at Shandong Taibang Facility 3DaVita HealthCare Partners Celebrates New-Teammate Training and Leadership Milestone 2DaVita HealthCare Partners Celebrates New-Teammate Training and Leadership Milestone 3
Cached News: