HOME >> MEDICINE >> NEWS
Crystal Structure Of gp120 Reveals HIV In Action

NEW YORK, NY, 1998 -- In the long battle against AIDS, a philosophy of "know the enemy" has guided basic research. Specifically, investigators have sought a viral Achilles heel by dissecting the precise molecular choreography that unfolds as HIV penetrates the linchpin-like T cells of the immune system. Now, an unprecedented peek at that process -- a viral surface glycoprotein caught in the act of binding a CD4 T cell receptor -- graces the covers of both the June 18 issue of Nature and the June 19 issue of Science magazines.

The long-sought crystal structure of gp120 in action is a collaborative effort led by researchers from the Columbia University College of Physicians & Surgeons, and the Dana-Farber Cancer Institute. "The crystal structure tells us how the virus is able to bind to the receptor at the same time that it remains sufficiently changeable to avoid immune detection. There is the potential for the information to be used to design compounds that interfere and block that interaction," says Wayne Hendrickson, Ph.D., professor of biochemistry and molecular biophysics at Columbia University and a Howard Hughes Medical Institute Investigator. Adds Peter Kwong, Ph.D., associate research scientist at Columbia and lead author on the first Nature paper, "Knowing the structure down to the atomic details will provide valuable clues for vaccine design."

X-ray crystallography is a technique that passes X-rays through a crystal from many angles, determines their pattern of diffraction, and then assembles the data to reveal the crystal's 3-dimensional structure, or conformation. The technique was key in solving the structure of DNA in 1953 and, more recently, in discovering the structure of HIV protease, which led to development of protease inhibitors.

But X-ray crystallography requires crystallizing a compound, which was no small feat for gp120. "The mechanisms that HIV has to protect itself from
'"/>

Contact: Carolyn Conway
cc328@columbia.edu
212-305-3900
Columbia University Medical Center
17-Jun-1998


Page: 1 2 3

Related medicine news :

1. Crystal methamphetamine use increases HIV risk
2. Crystallographers meet in Los Angeles
3. Repeated Exposure To Cocaine Alters Brain Structure
4. Fertilization Protein Structure To AID in Leukemia Treatment
5. Livers From Children Are Going To Adults, University Of Pittsburgh Review Of National Data Reveals
6. Study Reveals Prominent Fears Of School-Age Children
7. Study Reveals Gender Affects Lung-Cancer Development
8. Study Of Women And Hearing Reveals Need For Routine Hearing Tests
9. Study Reveals Possible Link Between Osteoarthritis, Diet
10. Beta-Blockers Underused In Older Patients After Heart Attacks, Major Study Of 45,000 Patients 65 Years Or Older Reveals
11. Study Reveals Possible Clue For Racial Differences In Prevalence Of High Blood Pressure

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Crystal Structure Reveals HIV Action

(Date:7/28/2014)... The Wireline Services Market in Europe report defines and ... forecast of revenue. The Wireline services market in Europe is ... $2.4 billion by 2019, at a CAGR of 11.2%, for ... Wireline Services Market in Europe report, to get an idea ... of the segmentation in the European Wireline Services market, and ...
(Date:7/28/2014)... (HealthDay News) -- A common inflammatory muscle disorder ... may increase the risk for heart attack and ... study found that patients with polymyalgia rheumatica are ... that affect the blood vessels. Doctors should carefully ... polymyalgia rheumatica to reduce their risk for complications, ...
(Date:7/28/2014)... two-step decision tree analysis, incorporating Donabedian,s model, is ... many available quality standards, guidelines, recommendations and indicators ... quality standards for radiation therapy, according to a ... Practical Radiation Oncology (PRO), the official ... Radiation Oncology (ASTRO). , Guidelines, recommendations and indicators ...
(Date:7/28/2014)... Mediaplanet announced distribution of its third ... campaign that aims to raise awareness about the benefits ... TEALUX , a premium loose leaf tea shop ... readers with educational insight about the accessibility and growth ... forward and make conscious organic choices an option for ...
(Date:7/28/2014)... (PRWEB) July 28, 2014 Synergy Business ... magazine, Accounting Today, to their 2014 list of top ... enterprise resource planning (ERP) software. This is the eighth ... the list, which is based on success in terms ... supported. , “It’s an honor to be counted ...
Breaking Medicine News(10 mins):Health News:Europe Wireline Services Market is Expected to Reach $2.4 billion in 2019 - New Report by MicroMarket Monitor 2Health News:Europe Wireline Services Market is Expected to Reach $2.4 billion in 2019 - New Report by MicroMarket Monitor 3Health News:Europe Wireline Services Market is Expected to Reach $2.4 billion in 2019 - New Report by MicroMarket Monitor 4Health News:Inflammatory Muscle Disorder May Raise Risk for Heart Attack, Stroke 2Health News:Two-step decision tree analysis helps inform updates of RT best practices, quality standards 2Health News:Two-step decision tree analysis helps inform updates of RT best practices, quality standards 3Health News:Mediaplanet's "Organic Living" Campaign Raises Awareness About What Nature Invented, With the Help of Partner TEALUX 2Health News:Synergy Business Solutions Selected to Top 100 VAR List for Eighth Year by Accounting Today 2Health News:Synergy Business Solutions Selected to Top 100 VAR List for Eighth Year by Accounting Today 3
(Date:7/28/2014)... LEHIGH VALLEY, Pa. , July 28, 2014 /PRNewswire/ ... a reliable, uninterrupted supply of medical oxygen is vital ... company to technical innovations that not only improve the ... gas use. Air Products will highlight these systems—including systems ... systems that reduce oxygen loss—from August 4-5 at the ...
(Date:7/28/2014)... 28, 2014  Array BioPharma Inc. (Nasdaq:   ... fourth quarter and full year of fiscal ... discuss those results on Tuesday, August 12, ... Michael Carruthers , Chief Financial Officer ... 12, 2014Time:9:00 a.m. Eastern TimeToll-Free:(800) 708-4540Toll:(847) 619-6397Pass ...
(Date:7/28/2014)... -- Houston dentist , Dr. Behzad Nazari ... Invisalign. With access to this increasingly popular orthodontic ... without feeling self-conscious in the process. Invisalign offers ... of braces, but patients who choose Invisalign over ... support for their oral health and comfort during ...
Breaking Medicine Technology:Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 2Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 3Houston Cosmetic Dentist, Dr. Behzad Nazari, Now Offers Orthodontic Treatment with Invisalign 2
Cached News: