HOME >> MEDICINE >> NEWS
Cure Rate Soars For Some AML Patients Receiving High-Dose Drug

COLUMBUS, Ohio -- A drug given at levels substantially higher than the standard dose can cure nearly five times as many patients who have a certain type of acute myeloid leukemia (AML), new research shows.

The study revealed that 78 percent of patients with “core binding factor” AML who received the drug cytarabine at high dose were in complete remission five years after treatment (and therefore potentially cured) compared to only 16 percent who received the standard dose.

“It is truly remarkable to achieve a cure rate of over 75 percent in a subgroup of adult leukemia patients; this rate approaches that for some types of childhood leukemia,” said Clara Bloomfield, director of Ohio State University's Comprehensive Cancer Center and William G. Pace III Professor of Cancer Research.

“Because high-dose cytarabine is quite toxic, especially for older people, we want to use it only with those patients who will benefit. These results tell us which patients we can cure, and which ones should receive other therapy.”

The finding is considered particularly strong because the study had followed patients for more than seven years after treatment; most such studies rely on models to project estimates of five-year remission rates.

The study, which was led by Bloomfield, appeared in the September issue of the journal Cancer Research. It involved 285 newly diagnosed AML patients aged 16 and older who were in remission. During the second phase of their treatment, a phase known as “intensification therapy,” the patients were randomly assigned to receive cytarabine at either standard dose (100 milligrams per square meter
'"/>

Contact: Clara Bloomfield
bloomfield-1@medctr.osu.edu
614-293-7518
Ohio State University
29-Oct-1998


Page: 1 2 3

Related medicine news :

1. Patients newly diagnosed with HIV are more likely to enter outpatient care with case management
2. Patients with cancer have highly increased risk for blood clots
3. Patients with previous heart attacks may not benefit from pacemaker implant
4. Patients with cancer detected on screening mammography undergo less toxic treatment
5. Patients with moderate or severe hand dermatitis responsive to drug therapy
6. Patients with abdominal trauma at risk for intra-abdominal infections following surgery
7. Patients who are intubated prior to hospital arrival fare worse find Pitt researchers
8. Patients undergoing weight loss surgery have high rates of H pylori bacteria
9. Patients with chronic sinus do not necessarily develop antibiotic resistance
10. Plastic surgeons honor Patients of Courage overcoming difficult obstacles, inspiring others
11. Patients with severe depression improve using guidelines developed by UT Southwestern researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/16/2017)... ... January 16, 2017 , ... Board-certified oculoplastic surgeon Dr. Mehryar ... official journal of The American Society for Aesthetic Plastic Surgery, in which he ... designed to correct drooping, retracted lower eyelids, which usually result from genetics, injury, ...
(Date:1/16/2017)... ... January 16, 2017 , ... San Francisco dentist, Dr. ... latest in 3-D scanning device which is capable of taking digital impressions of teeth ... dentistry, such as CAD CAM restorations , in terms of speed, efficiency and ...
(Date:1/15/2017)... ... ... In this role, Courtney will be responsible for developing new business initiatives ... mark. This certification program was created by ASL and the nonprofit Asthma and Allergy ... for the 60+ million people living in the U.S. with asthma and allergies. Courtney ...
(Date:1/15/2017)... , ... January 15, 2017 , ... ... Albertsons Companies has achieved accreditation for its specialty care services. Albertsons Companies ... own in-house specialty care service for pharmacy patients. , Accreditation by ACHC reflects ...
(Date:1/15/2017)... Chicago, IL (PRWEB) , ... January 14, 2017 , ... ... a Lobster Gram Dinner delivered straight to your door for a romantic, lobster feast ... dinners, just in time for Valentine's Day. The dinners will be featured until ...
Breaking Medicine News(10 mins):
(Date:1/13/2017)... Wichita Laser Clinic at Healthy ... Wichita, Kansas featuring the Astanza ... skin rejuvenation, getting rid of unwanted tattoos, killing toenail ... "Since being in the aesthetics industry, I ... for laser tattoo removal and other popular ...
(Date:1/13/2017)... 2017 On Thursday, January 12, ... and the S&P 500 edged lower at the closing ... session in bearish territories. Taking into consideration yesterday,s market ... morning: Myriad Genetics Inc. (NASDAQ: MYGN ), ... Holdings Inc. (NASDAQ: INCR ), and La ...
(Date:1/13/2017)... 2017  Secretary of Health Karen Murphy ... members at Misericordia University and discussed the Wolf Administration,s ... Pennsylvania . "The opioid epidemic is ... in my professional career," Secretary Murphy said. "This area ... hard by heroin and prescription opioid overdoses. Across the ...
Breaking Medicine Technology:
Cached News: