Dr. Sonia Cavigelli, assistant professor of biobehavioral health, says that her study of 80 female rats from birth to death shows that the curious ones with tumors lived, on average, an additional six months, or 25 percent longer lives, than the cautious ones.

"It's difficult to extrapolate from rats to people, she notes.However, there have been studies that show that shy elderly people report more health symptoms than their more outgoing age-mates. Our new results with rats are consistent with those findings and support the notion that personality traits may have a significant impact on health and resilience to disease."

Cavigelli, who joined the Penn State faculty in August, detailed the results at the American Psychosomatic Society meeting in Vancouver, Canada, in a paper, Exploratory Tendency During Infancy and Survival in Female Rats with Spontaneous Tumors. She conducted the study while she was a postdoctoral researcher at the University of Chicago. Her co-authors are J. R. Yee, graduate student in human development, and Dr. Martha McClintock, professor of psychology, both at the University of Chicago.

The rats used in the study spontaneously develop breast or pituitary tumors near the end of their lives. In the study, 93 percent of the rats developed these tumors.

Cavigelli says,"Tumor progression is a lengthy process and, therefore, may be particularly prone to subtle effects of personality on disease resilience."

The rats were tested in infancy and as adults to see how curious or cautious they were by placing them in a "playground" filled with unfamiliar objects likely to intrigue rodents, including tunnels, bricks, stones and a small box. Some of the rats, from infancy, readily explored the environment and were designated "curio
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Contact: Barbara Hale
bah@psu.edu
814-865-9481
Penn State
7-Mar-2005