'DES Daughters' Had Increased Rates of Cancer; An Animal Study Shows 'DES Granddaughters' May Too

Like 'DES daughters,' DES granddaughters may have an increased risk of reproductive tract cancers, an animal study published today suggests.

DES, or diethylstilbestrol, is the synthetic estrogen once used in attempts to treat women at risk for miscarriage..

Now, scientists at the National Institute of Environmental Health Sciences report that they have observed an increase in cancers, including cancer of the uterus, in female mice whose mothers were exposed to DES in utero -- while in the uterus. The subsequent generation of female mice reported today was not exposed to DES.

While both generations had increased reproductive tract cancers, fertility was impaired only in the female mice exposed to DES in utero (the 'DES daughters') but not in their unexposed female offspring (the 'DES granddaughters'), the scientists said.

The study was reported today in the scientific journal Carcinogenesis (September, pp. 1655-1663) by Retha R. Newbold, Rita B. Hanson and Wendy N. Jefferson, all of NIEHS; Bill C. Bullock of the Bowman-Gray School of Medicine at Wake Forest University, Winston-Salem, N.C.; Joseph Haseman of NIEHS, and John A. McLachlan of Tulane/Xavier Center for Bioenvironmental Research, Tulane University, New Orleans.

Newbold and her colleagues said "the data suggest transmission of susceptibility of genital tract cancers to subsequent generations." They said this concept is supported by results in male mouse siblings in which like the females described in this study, reproduction is not affected but rare cancers are observed. A report on the effects in males is being completed, Newbold said.

Newbold and her colleagues said that although additional study of risks from environmental agents are needed, the findings "indicate that the cascade of events that lead to the appearance of a tumor may well begin before birth and perhaps before conception."

For more t

Contact: Bill Grigg
(301) 402-3378
NIH/National Institute of Environmental Health Sciences

Page: 1 2

Related medicine news :

1. Daughters vulnerability, source of depression in women at high risk for ovarian cancer
2. Increased physical activity not linked to ALS risk
3. Increased suicide rate is possibly linked to chemicals released from nearby asphalt plants
4. Increased investment in radiotherapy will improve cure rates for European cancer patients
5. Increased use of CT in past decade results in decreased costs for hospitals
6. Increased risk of cardiovascular disease shown in PCOS patients
7. Increased HIV risk for women with violent male partners
8. Increased prevalence of diabetes - not all bad news
9. Increased heart mortality rates linked to lower state subsidies of uninsured in New Jersey
10. Increased parental mortality after death of a child
11. Increased risk of ovarian cancer is linked to estrogen replacement therapy

Post Your Comments:

(Date:1/14/2019)... ... January 14, 2019 , ... Modere (the “Company”), ... with a presence worldwide, today announced that it built on 2017’s growth momentum, ... grew by double-digits in North America, by more than five times in Europe ...
(Date:1/14/2019)... ... January 14, 2019 , ... The ... availability of VARIZIG® (Varicella Zoster Immune Globulin [Human]) for post-exposure prophylaxis of ... the update, the CDC notes that VARIZIG is commercially available from a broad ...
(Date:1/14/2019)... ... 2019 , ... Dr. Kaveh Kanani D.D.S . is the head of Around the Corner ... general dentist has recently unveiled an inventive method of inserting dental implants. , ... is missing for an extended period of time, the jawbone that used to hold the ...
(Date:1/13/2019)... ... January 12, 2019 , ... On December 13th, The Pennsylvania ... hosted a continuing education (CEU) event entitled, Can You Hear Me Now? Creating ... a series of talks to help develop and cultivate the relationship between mentors ...
(Date:1/11/2019)... ... 11, 2019 , ... In Partnership with the Smiles for Everyone Foundation ... at its Burleson, TX office on February 9. , Dental services provided ... and extractions . For more information, please visit the Monarch Dental website ...
Breaking Medicine News(10 mins):
(Date:1/10/2019)... (PRWEB) , ... January 10, 2019 , ... ... wellness company providing nutrition and lifestyle solutions, will crown the U.S. winner of ... Period’s 15 finalists include: Andrea Carrara of Palm Beach, Florida; Barbara Lingle of ...
(Date:1/8/2019)... , ... January 08, 2019 , ... ... been designated as a UroLift® Center of Excellence. The designation recognizes that Dr. ... System and demonstrated a commitment to exemplary care for men suffering from symptoms ...
(Date:1/8/2019)... ... January 08, 2019 , ... Date aired: August 13th, 2018 , Guest: ... excessive evaporation of the tear film, which is naturally 99 percent water, and it ... says water researcher Sharon Kleyne, host of the internationally syndicated radio program, The Sharon ...
Breaking Medicine Technology:
Cached News: