DHEA may help decrease abdominal fat in elder...( abdomen) and subcutaneous abdominal fa...),Health

abdomen) and subcutaneous abdominal fat (below the skin surface) in elderly men and women. "The decrease in visceral fat relative to initial values averaged 10.2 percent in the women and 7.4 percent in the men. The DHEA therapy also resulted in a significant decrease in abdominal subcutaneous fat, averaging approximately 6 percent in both the men and women," the researchers write. The DHEA replacement also resulted in a significant improvement in insulin action that correlated with the reduction in visceral fat.

"These findings provide evidence that DHEA replacement may partially reverse the aging-related accumulation of abdominal fat in elderly people with low serum levels of DHEAS. They also raise the possibility that long-term DHEA replacement therapy might reduce the accumulation of abdominal fat and protect against development of the metabolic/insulin resistance syndrome," they write.

"Limitations of our study include the relatively small number of participants and the short duration of DHEA replacement. Therefore, our findings should be considered preliminary," the authors write. "Larger-scale and longer-term studies are needed to determine whether DHEA replacement has any adverse effects and will be needed to verify our findings and should include patient groups that are fully representative of the population at risk."

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Contact: Diane Duke Williams
314-286-0111
JAMA and Archives Journals
9-Nov-2004

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