DNA-Based Cancer Vaccine Shows Promise To Successfully Treat Melanoma In Mice

New York, September 15, 1998 -- Over the past decade, knowledge about how the immune system can be used to fight cancer has greatly increased. Not only have scientists learned that the immune system can recognize certain proteins on cancer cells, but they have used this knowledge to develop vaccines that may help to prevent cancer recurrence.

Now, scientists at Memorial Sloan-Kettering Cancer Center in New York have shown that a new DNA-based vaccine can successfully treat the deadly skin cancer, melanoma, in mice. The investigators, who report their findings in the September 15 issue of the Journal of Clinical Investigation, used a "needleless syringe" called a gene gun to drive tiny particles of human DNA at high speed into the mice's skin. The human protein differed just enough from its mouse counterpart to trick the immune system into producing a powerful immune attack. The immune cells attacked both the melanoma cells and the pigment cells in the skin of the mice, which share a protein called gp75 that is not found in other tissues.

"Our study shows how we can use DNA immunization to make the immune system recognize and attack cancer cells," said Dr. Alan Houghton, Chief of the Clinical Immunology Service at Memorial Sloan-Kettering and senior author of the study. The same strategy is being tested against prostate, breast and lymphoma cancers in mice, as they also share specific proteins with their normal cell counterparts.

"These DNA vaccines are unique because they can trigger immunity where other types of vaccines can fail to stimulate an immune response," added Dr. Houghton, noting that they are easy to make, handle and store.

The mice were immunized with human DNA via a novel delivery system called a gene gun, in which microscopic gold particles were coated with the human DNA and injected into the mice's skin using a burst of helium gas. Once inside the sk

Contact: Kelli Stauning
(212) 639-3573
Memorial Sloan-Kettering Cancer Center

Page: 1 2

Related medicine news :

1. Cancer in patients with hepatitis C
2. Olson family donates $1 million to Arizona Cancer Center
3. Cancer vaccines: A two-pronged attack?
4. Mayo Clinic Cancer Center receives SPORE grant for brain cancer research from NCI
5. ESMO and Imedex announce partnership for the World Congress on Gastrointestinal Cancer
6. UT Southwestern Moncrief Cancer Center is first in Texas to treat patients with TomoTherapy
7. Cancer researchers seek to predict tumor growth
8. UGA professor receives $3 million grant from National Cancer Institute for breast cancer research
9. Cancer patients in Europe unite with doctors
10. Fox Chase Cancer Center researchers identify novel target for detecting ovarian cancer in blood
11. Cancer burden seen even many years after diagnosis

Post Your Comments:

(Date:1/10/2020)... , ... January 10, 2020 , ... WellHaven Pet Health, ... partnership in a new online community coming in February 2020, LEAD WELL with WOMEN. ... and Wellbeing Village. , The vision of LEAD WELL with WOMEN is to empower ...
(Date:1/10/2020)... ... January 10, 2020 , ... NW Women’s ... friendly, non-intimidating environment for all women. In search for a valuable nutrition solution, ... prospective members. , For nearly 30 years, Balanced Habits, headquartered in Southern ...
(Date:1/8/2020)... ... January 08, 2020 , ... Mirror ... Magazine’s 2019 Best of Memorial Readers’ Choice Awards. Located adjacent to ... named Best MedSpa in Memorial reflects Mirror Mirror Beauty Boutique’s commitment to the ...
(Date:1/7/2020)... ... January 07, 2020 , ... G-CON Manufacturing, the leader ... company’s 200,000 sq. ft. manufacturing site in College Station, TX. The new facility, ... POD architectural, mechanical, electrical and automation fit out. , “This facility allows us ...
(Date:1/7/2020)... (PRWEB) , ... January 07, 2020 , ... CBD ... can be created while keeping the focus on the individual customer service experience. Transparency ... their customers first and the profits second. By taking care of the people first, ...
Breaking Medicine News(10 mins):
(Date:1/8/2020)... ... January 09, 2020 , ... R3 Stem Cell is now offering ... first rate presentations and procedure videos. The course is incredibly useful and provides a ... For years, R3 Stem Cell has been the leader for regenerative training with in ...
(Date:1/7/2020)... ... January 07, 2020 , ... Ironsphere, a secure access management ... it has been selected by MetLife Stadium for Privileged Access Management (PAM) security ... our ongoing commitment to maintain the highest of security policies, our IT and ...
(Date:1/7/2020)... CHURCH, Va. (PRWEB) , ... January 07, 2020 ... ... Focus, An FDAnews Webinar, Tuesday, Jan. 21, 2020, 11:00 a.m.-12:30 p.m. EST, ... (IVD) industry market globally. It is the only market with a 20 percent ...
Breaking Medicine Technology:
Cached News: