HOME >> MEDICINE >> NEWS
DNA-Based Cancer Vaccine Shows Promise To Successfully Treat Melanoma In Mice

New York, September 15, 1998 -- Over the past decade, knowledge about how the immune system can be used to fight cancer has greatly increased. Not only have scientists learned that the immune system can recognize certain proteins on cancer cells, but they have used this knowledge to develop vaccines that may help to prevent cancer recurrence.

Now, scientists at Memorial Sloan-Kettering Cancer Center in New York have shown that a new DNA-based vaccine can successfully treat the deadly skin cancer, melanoma, in mice. The investigators, who report their findings in the September 15 issue of the Journal of Clinical Investigation, used a "needleless syringe" called a gene gun to drive tiny particles of human DNA at high speed into the mice's skin. The human protein differed just enough from its mouse counterpart to trick the immune system into producing a powerful immune attack. The immune cells attacked both the melanoma cells and the pigment cells in the skin of the mice, which share a protein called gp75 that is not found in other tissues.

"Our study shows how we can use DNA immunization to make the immune system recognize and attack cancer cells," said Dr. Alan Houghton, Chief of the Clinical Immunology Service at Memorial Sloan-Kettering and senior author of the study. The same strategy is being tested against prostate, breast and lymphoma cancers in mice, as they also share specific proteins with their normal cell counterparts.

"These DNA vaccines are unique because they can trigger immunity where other types of vaccines can fail to stimulate an immune response," added Dr. Houghton, noting that they are easy to make, handle and store.

The mice were immunized with human DNA via a novel delivery system called a gene gun, in which microscopic gold particles were coated with the human DNA and injected into the mice's skin using a burst of helium gas. Once inside the sk
'"/>

Contact: Kelli Stauning
staunink@mskcc.org
(212) 639-3573
Memorial Sloan-Kettering Cancer Center
15-Sep-1998


Page: 1 2

Related medicine news :

1. Cancer in patients with hepatitis C
2. Olson family donates $1 million to Arizona Cancer Center
3. Cancer vaccines: A two-pronged attack?
4. Mayo Clinic Cancer Center receives SPORE grant for brain cancer research from NCI
5. ESMO and Imedex announce partnership for the World Congress on Gastrointestinal Cancer
6. UT Southwestern Moncrief Cancer Center is first in Texas to treat patients with TomoTherapy
7. Cancer researchers seek to predict tumor growth
8. UGA professor receives $3 million grant from National Cancer Institute for breast cancer research
9. Cancer patients in Europe unite with doctors
10. Fox Chase Cancer Center researchers identify novel target for detecting ovarian cancer in blood
11. Cancer burden seen even many years after diagnosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/17/2019)... ... July 17, 2019 , ... A new study led ... of the American Medical Association (JAMA), shows for the first time that New ... the state. Sepsis is the body’s extreme response to infection. It kills more than ...
(Date:7/17/2019)... ... 2019 , ... Women’s Excellence is pleased to announce a new office opening in Lapeer, Michigan. ... offices resides on the corner of Turrill Road and South Lapeer Roads, conveniently off of ... opening of our new office in Lapeer and the ability to service women in this ...
(Date:7/13/2019)... CHICAGO (PRWEB) , ... July 13, 2019 , ... ... its most advanced and innovative rechargeable vibrator and clitoral massager. To view the product ... to offer our newest and most advanced, personal massagers to people around the world,” ...
(Date:7/13/2019)... ... July 12, 2019 , ... cbdMD, Inc., a ... “Brand to Watch” by Brightfield Group, a leading cannabis research firm. In their ... of domestic CBD companies in two categories, Topicals and Skincare/Beauty. , "There is ...
(Date:7/12/2019)... ... July 12, 2019 , ... Fruit Street Health ( http://www.fruitstreet.com ... diabetes prevention program from the Centers for Disease Control and Prevention (CDC). Fruit ... recognition from CDC that delivers the diabetes prevention program via telemedicine and live ...
Breaking Medicine News(10 mins):
(Date:7/17/2019)... ... July 17, 2019 , ... ... an industry expansion into the healthcare sector during the second quarter of 2019. ... revenue cycle management join a strong client list in managing and mitigating ...
(Date:7/17/2019)... ... July 16, 2019 , ... For the fifth consecutive year, ... its excellence in healthcare-professional marketing and media. This year, ReachMD is a finalist ... Team, (3) Best Young Marketer , The MM&M Awards honor the best in ...
(Date:7/17/2019)... ... 2019 , ... Women’s Excellence is pleased to offer Natural Family Planning (NFP) ... method of birth regulation that is consistent with Catholic marriage vows by which a ... couple abstains from all sexual contact during the fertile time. To achieve pregnancy, the ...
Breaking Medicine Technology:
Cached News: