HOME >> MEDICINE >> NEWS
Decreased diabetic cardiac death from losartan?

The angeotensin 2 receptor blocker losartan could be more effective than a beta blocker in reducing sudden cardiac death among diabetic patients with high blood pressure and an enlarged left ventricle (left ventricular hypertrophy), suggest authors of a research letter in this week's issue of THE LANCET.

The Losartan Intervention For Endpoint reduction in hypertension (LIFE) study published by THE LANCET in March 2002 demonstrated a major reduction of all-cause mortality-especially cardiovascular mortality-in patients with diabetes with left ventricular hypertrophy treated with losartan. The LIFE diabetes study investigators (led by Lars Hjalmar Lindholm from Umea University, Sweden, and colleagues) proposed that losartan might offer better protection against sudden cardiac death than atenolol.

In a post-hoc analysis of 1195 participants in the LIFE study, 44 patients with diabetes, hypertension and left ventricular hypertrophy died of sudden cardiac death. Substantially fewer deaths arose in the losartan group (14 out of 586) than in the atenolol group (30 out of 609). The results showed a close to 50% risk reduction in sudden death in losartan-treated patients compared with those treated with atenolol.

Lars Lindholm comments: "The reduction in sudden cardiac death with losartan was only evident for diabetic patients. These results are, however, exploratory, and require confirmation."

In an accompanying Commentary (p 591) Wilbert S Aronow from Westchester Medical Centre and New York Medical College, USA, concludes: "Lindholm and colleagues' new analysis, and their previous report, showing a significant reduction in cardiovascular mortality and in all-cause mortality by losartan compared with atenolol show that losartan is more effective than atenolol in treating hypertensive diabetic patients with left ventricular hypertrophy. However, a large double-blind randomised trial is necessary to investigate whether losartan is better, simi
'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
212-633-3810
Lancet
21-Aug-2003


Page: 1 2

Related medicine news :

1. Decreased levels of good cholesterol in children with Progeria may cause premature heart disease
2. Decreased sensitivity in the brain to estrogen may help explain menopausal changes
3. Decreased diabetic cardiac death from losartan?
4. Decreased pain perception may help to identify hypertension risk
5. Study of obese diabetics explains why low-carb diets produce fast results
6. Jefferson scientists uncover potential trigger of diabetic kidney disease
7. Penn study shows how next-generation diabetic drugs could work more selectively
8. Aspirin underused to reduce heart disease risk in diabetic women and young adults
9. Diabetics with mental disorders at increased risk for diabetic complications
10. Testosterone deficiency found in one-third of diabetic men
11. University health study identifies undiagnosed diabetics

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2020)... ... March 27, 2020 , ... Suntuity ... Group of companies, is mobilizing their drone equipment and training personnel to help ... their DJI Enterprise level Matrice and Agras drones, Suntuity AirWorks is mobilizing their ...
(Date:3/28/2020)... ... March 28, 2020 , ... iPatientCare, ... practice management, and patient engagement solutions has expanded the availability of telehealth services ... time of crisis, telemedicine has a big role in fighting coronavirus . ...
(Date:3/27/2020)... VEGAS (PRWEB) , ... March 27, 2020 , ... During a time of global distress ... merchant processing, is donating to the UNITE HERE Education and Support Fund in ... pandemic. , UNITE HERE represents 300,000 working people in the food ...
(Date:3/22/2020)... ... March 22, 2020 , ... In times of crisis, like ... frivolous luxury. The world’s focus is on practical matters - on self-isolation, social ... and control in chaos. However, it’s during these times that “self-awareness” is crucial, ...
(Date:3/19/2020)... ... ... Therapies of The Rockies has Colorado’s back, and they are here to support ... across the country, as remote therapy services have no geographic boundaries. Reach out to ... safely! , Therapies of The Rockies is a Denver-area speech, language, occupational, and physical ...
Breaking Medicine News(10 mins):
(Date:3/20/2020)... ... 2020 , ... The economic fallout from the novel coronavirus ... most vulnerable community members are those that struggle to pay for basic household ... Constrained, Employed). Today, these ALICE households face an even more uncertain future. , ...
(Date:3/19/2020)... ... March 19, 2020 , ... As COVID-19 spreads across the ... us to practice social distancing and, in some cases, self-quarantine to help stop the ... people who have underlying mental health issues. , Cindy Gipson, Ph.D., serves as ...
(Date:3/16/2020)... ... March 16, 2020 , ... In response to the COVID-19 pandemic, ... are also closing nationwide . As of March 15, public schools across at least ... means working from home while their children are also present. To help working parents ...
Breaking Medicine Technology:
Cached News: