DepoDur found to be innovative option for postoperative pain relief

CHADDS FORD, Pa., October 26, 2004 Data from two clinical trials presented at the American Society of Anesthesiologists' Annual Meeting in Las Vegas this week support the safety and efficacy of DepoDurTM (morphine sulfate extended-release liposome injection) CII -- an innovative single-dose epidural injection designed to improve postoperative pain control. DepoDurTM will be commercially available in the U.S. by the end of 2004.

DepoDurTM was approved by the U.S. Food and Drug Administration (FDA) in May 2004 for the treatment of pain following major surgery. It is given as a single epidural injection before or during surgery in procedures such as hip and knee replacement, lower abdominal surgery and elective Caesarean section. Unlike currently available epidural morphine formulations, DepoDurTM can provide up to 48 hours of effective pain relief with a single shot. Furthermore, DepoDurTM does not require an indwelling catheter for continuous infusion, which may limit patient mobility and present obstacles for administering anticoagulant (blood thinning) therapy. This new therapeutic option may help physicians overcome challenges associated with current postoperative pain treatment options while providing safe and effective pain control.

"DepoDurTM has been shown to offer effective pain control while streamlining the process of peri-operative pain management," said Gavin Martin, M.D., assistant clinical professor of anesthesiology, Duke University and an investigator in clinical trials. "Soon patients will be able to experience up to 48 hours of pain relief post-surgery with a single shot. This product will help enable healthcare professionals to achieve optimal pain control for their patients without the many challenges commonly associated with postoperative pain relief."

The majority of surgical patients experience moderate-to-severe postoperative pain, but the treatmen

Contact: Wendy Lu
Cohn & Wolfe

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