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DepoDur found to be innovative option for postoperative pain relief

was developed by SkyePharma Inc. Under an agreement with SkyePharma, Endo Pharmaceuticals has exclusive rights to market DepoDurTM in the U.S. and Canada. For complete prescribing information, please visit www.depodur.com.

* DepoDurTM is not FDA-approved at the 5, 25 or 30 mg doses. It is FDA-approved at the 10, 15 and 20 mg doses.

About Endo

A wholly owned subsidiary of Endo Pharmaceuticals Holdings Inc. (Nasdaq: ENDP), Endo Pharmaceuticals is a fully integrated specialty pharmaceutical company with market leadership in pain management products. The company researches, develops, produces and markets a broad product offering of branded and generic pharmaceuticals, meeting the needs of healthcare professionals and consumers alike. More information, including this and past press releases of Endo Pharmaceuticals Holdings Inc., is available online at www.endo.com.

Forward Looking Statements

This press release contains forward-looking statements, within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, as amended, that are based on management's beliefs and assumptions, current expectations, estimates and projections. Statements that are not historical facts, including statements which are preceded by, followed by, or that include, the words "believes," "anticipates," "plans," "expects" or similar expressions and statements are forward-looking statements. Endo's estimated or anticipated future results, product performance or other non-historical facts are forward-looking and reflect Endo's current perspective on existing trends and information. Many of the factors that will determine the Company's future results are beyond the ability of the Company to control or predict. These statements are subject to risks and uncertainties and, therefore, actual results may differ materially from those expressed or imp
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Contact: Wendy Lu
wendy_lu@nyc.cohnwolfe.com
212-798-9839
Cohn & Wolfe
26-Oct-2004


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