HOME >> MEDICINE >> NEWS
Depression caused by common treatment for hepatitis C may affect outcome

ATLANTAAn article appearing in the January 2005 issue of Brain, Behavior and Immunity suggests that developing depression while on interferon-alpha plus ribavirin may impact how well the medications work.

In a study conducted in the Department of Psychiatry and Behavioral Sciences at Emory University School of Medicine, Charles L. Raison, MD, Andrew Miller, MD, and colleagues, observed that patients who develop depressive symptoms during interferon-alpha plus ribavirin therapy were significantly less likely to have cleared the hepatitis C virus from their blood following six months of treatment.

"Hepatitis C infection affects three to five million Americans, and is the leading cause of liver transplantation," said Dr. Raison. "With advances in treatment, 40-50 percent of patients can be cleared of the virus. Unfortunately, however, the current treatment for hepatitis C interferon-alpha plus ribavirin produces a high rate of psychiatric side effects that have long been recognized as impediments to successful antiviral therapy. In the past we primarily worried that depression interfered with quality of life, or would cause patients to stop taking the medicine. These new data suggest that even if patients stay on treatment, they are less likely to have a good outcome if they develop depression."

The study examined 103 participants who received pegylated interferon-alpha-2b plus ribavirin (PEG IFN/ribavirin). All participants were psychiatrically evaluated prior to initiation of the medication and at 4, 8, 12 and 24 weeks of PEG IFN/ribavirin treatment.

Only 34% of the patients who had a significant increase in depression cleared the hepatitis C virus from their blood at 24 weeks, as compared to 59%-69% of patients with milder increases in depression. The effect of depression on viral clearance persisted even after adjusting for factors known to affect treatment outcome, such as viral genotype, or whether medications had to
'"/>

Contact: Kathi Baker
kobaker@emory.edu
404-727-9371
Emory University Health Sciences Center
14-Jan-2005


Page: 1 2

Related medicine news :

1. Depression linked to insomnia in HIV patients
2. Depression may explain higher risk of heart attack associated with antidepressants
3. Depression predicts heart rhythm abnormalities in heart attack patients
4. Depression tied to higher risk of heart disease death
5. Depression predicts mortality in women with heart disease
6. Depression can lead to back pain
7. Depression on College Campuses conference
8. Depression may be a risk factor for heart disease, death in older women
9. Depression, other psychiatric illnesses common following traumatic brain injury
10. Depression, trauma stress linked to physical complaints
11. Depression doubles risk of death after bypass surgery

Post Your Comments:
(Date:7/31/2014)... Dublin, Ohio (PRWEB) July 31, 2014 ... solutions for health care, announces the release of a “Twelve ... web seminar for hospitals that are evaluating Health Information Service ... 2. Hospitals that utilize MEDITECH and Epic electronic health ... order to exchange transitions of care using the Direct protocol. ...
(Date:7/31/2014)... 2014 A cancer diagnosis is crushing and ... and resume normal lives. This is particularly true of prostate ... one in seven American men but which when detected early, ... rate of nearly 100% and a ten-year survival rate of ... diagnosed with the disease do not die from it. There ...
(Date:7/31/2014)... its latest blog post, Best Drug Rehabilitation , which ... during a stay in rehab can make a big difference ... on nine secrets that addicts don’t want others to know. ... an addict from a mile away, and totally understand what’s ... Per Wickstrom . “However, take it from me: spotting ...
(Date:7/31/2014)... July 31, 2014 In its latest blog ... and believes that having family close by during a stay ... not the process is successful, is looking at 10 tips ... , “Addiction recovery is a lifelong process, and one ... be committed to without compromise,” commented Best Drug Rehabilitation’s CEO ...
(Date:7/31/2014)... Oregon (PRWEB) July 31, 2014 ... properties and digestibility, erythritol has long been used ... such as stevia and monk fruit. However consistent, ... In an effort to meet food and beverage ... sourcing, Steviva Ingredients has launched GMO-free ErysweetTM Erythritol. ...
Breaking Medicine News(10 mins):Health News:Updox Introduces Resources to Help Hospitals Choose the Right HISP for Direct Messaging 2Health News:Updox Introduces Resources to Help Hospitals Choose the Right HISP for Direct Messaging 3Health News:Updox Introduces Resources to Help Hospitals Choose the Right HISP for Direct Messaging 4Health News:Restoring Intimacy after Prostate Cancer; Dr. Daniel Watter with Morris Psychological Group Offers Tips for Patients and their Partners 2Health News:Restoring Intimacy after Prostate Cancer; Dr. Daniel Watter with Morris Psychological Group Offers Tips for Patients and their Partners 3Health News:Restoring Intimacy after Prostate Cancer; Dr. Daniel Watter with Morris Psychological Group Offers Tips for Patients and their Partners 4Health News:Latest Best Drug Rehabilitation Blog Posts Focuses on Nine Secrets Addicts Don’t Want Others to Know 2Health News:Latest Best Drug Rehabilitation Blog Posts Focuses on Nine Secrets Addicts Don’t Want Others to Know 3Health News:New Best Drug Rehabilitation Blog Posts Looks at 10 Tips for Coping After Drug or Alcohol Rehab 2Health News:Steviva Ingredients Launches Erysweet Erythritol 2
(Date:7/30/2014)... Calif. , July 30, 2014  El Camino ... improve patient care, is utilizing the Leaf Patient Monitoring ... the position and movement of patients susceptible to bed ... a six month-long, 138-patient study of the system, which ... turn protocols. Turning patients regularly is the one of ...
(Date:7/30/2014)... July 30, 2014  InnoPharma, Inc. today announced the ... generic equivalent of Zyprexa® injection), in Canada.  Olanzapine is ... behaviors in patients with schizophrenia or bipolar I mania. ... drug, InnoPharma has entered into an agreement with Sandoz ... will make, use, sell, market and distribute Olanzapine Injection ...
(Date:7/30/2014)... July 30, 2014 Cynosure, Inc. (NASDAQ: ... aesthetic treatments for non-invasive and minimally invasive applications, today announced ... Chief Operating Officer and Chief Financial Officer Timothy W. ... 2014.  Baker, 53, will continue to serve as CFO and ... , who remains Chairman and Chief Executive Officer. ...
Breaking Medicine Technology:El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 2El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 3InnoPharma Announces Launch of Olanzapine for Injection, 10mg/vial in Canada 2Cynosure Appoints Chief Operating Officer and Chief Financial Officer Timothy W. Baker as President 2
Cached News: