HOME >> MEDICINE >> NEWS
Depression caused by common treatment for hepatitis C may affect outcome

ATLANTAAn article appearing in the January 2005 issue of Brain, Behavior and Immunity suggests that developing depression while on interferon-alpha plus ribavirin may impact how well the medications work.

In a study conducted in the Department of Psychiatry and Behavioral Sciences at Emory University School of Medicine, Charles L. Raison, MD, Andrew Miller, MD, and colleagues, observed that patients who develop depressive symptoms during interferon-alpha plus ribavirin therapy were significantly less likely to have cleared the hepatitis C virus from their blood following six months of treatment.

"Hepatitis C infection affects three to five million Americans, and is the leading cause of liver transplantation," said Dr. Raison. "With advances in treatment, 40-50 percent of patients can be cleared of the virus. Unfortunately, however, the current treatment for hepatitis C interferon-alpha plus ribavirin produces a high rate of psychiatric side effects that have long been recognized as impediments to successful antiviral therapy. In the past we primarily worried that depression interfered with quality of life, or would cause patients to stop taking the medicine. These new data suggest that even if patients stay on treatment, they are less likely to have a good outcome if they develop depression."

The study examined 103 participants who received pegylated interferon-alpha-2b plus ribavirin (PEG IFN/ribavirin). All participants were psychiatrically evaluated prior to initiation of the medication and at 4, 8, 12 and 24 weeks of PEG IFN/ribavirin treatment.

Only 34% of the patients who had a significant increase in depression cleared the hepatitis C virus from their blood at 24 weeks, as compared to 59%-69% of patients with milder increases in depression. The effect of depression on viral clearance persisted even after adjusting for factors known to affect treatment outcome, such as viral genotype, or whether medications had to
'"/>

Contact: Kathi Baker
kobaker@emory.edu
404-727-9371
Emory University Health Sciences Center
14-Jan-2005


Page: 1 2

Related medicine news :

1. Depression linked to insomnia in HIV patients
2. Depression may explain higher risk of heart attack associated with antidepressants
3. Depression predicts heart rhythm abnormalities in heart attack patients
4. Depression tied to higher risk of heart disease death
5. Depression predicts mortality in women with heart disease
6. Depression can lead to back pain
7. Depression on College Campuses conference
8. Depression may be a risk factor for heart disease, death in older women
9. Depression, other psychiatric illnesses common following traumatic brain injury
10. Depression, trauma stress linked to physical complaints
11. Depression doubles risk of death after bypass surgery

Post Your Comments:
(Date:3/26/2015)... (PRWEB) March 26, 2015 Innovative ... brain aneurysms and preventing often fatal ruptures, says ... dedicated to raising awareness of brain aneurysms and ... issue has captured national attention with the ... 49, who died last Friday after suffering a ...
(Date:3/26/2015)... The Pulmonary Hypertension Association ... Treatments Act (PATA) that was introduced in the ... B. McKinley (R-WV) and Lois Capps (D-CA). This ... medications placed in a specialty tier and make ... expenses. , This legislation is critical to individuals ...
(Date:3/26/2015)... In preparation for the 2016 United ... by Samir Becic, has issued “report cards” for ... and fitness, as well as their promotion of health ... Sen. Ted Cruz, who has officially announced his candidacy ... politicians who have shown interest in running for office. ...
(Date:3/26/2015)... March 26, 2015 Los Lunas, N.M., ... pageant. Not until last year, when she attended a ... pulmonary hypertension (PH) – a debilitating disease of the ... can lead to right-heart failure. The disease turned the ... 2003. Lyndsi entered the pageant to raise awareness about ...
(Date:3/26/2015)... 2015 DiabetesSisters is pleased to announce ... of $25,000 for a groundbreaking project in the field ... a partnering organization, The Society for Women’ Health Research, ... on women and diabetes. The “Women & Diabetes: 10Q ... research to improve the health and wellbeing of women ...
Breaking Medicine News(10 mins):Health News:Research and Funding Are Keys to Raising Awareness and Ultimately Preventing Fatal Brain Aneurysm Ruptures 2Health News:Research and Funding Are Keys to Raising Awareness and Ultimately Preventing Fatal Brain Aneurysm Ruptures 3Health News:Pulmonary Hypertension Association Part of Coalition Supporting the Patients’ Access to Treatments Act 2Health News:How the Candidates for the 2016 Presidential Election Rank in Health and Fitness 2Health News:How the Candidates for the 2016 Presidential Election Rank in Health and Fitness 3Health News:Albuquerque Area Mom Enters Mrs. New Mexico Pageant to Help Fight Pulmonary Hypertension 2Health News:DiabetesSisters Receives Financial Support for Landmark Report from Janssen Pharmaceuticals 2
(Date:3/26/2015)... März 2015  Die National Association of ... 2015 an Zulassungsanträge für Domainnamen mit der ... Seit dem Start des .Pharmacy Top-Level Domain- ... .pharmacy-Domainnamen zugelassen, die für die vorherigen, begrenzten ... Die NABP startete .pharmacy TLD, um Verbrauchern ...
(Date:3/26/2015)... Mass. , March 26, 2015 /PRNewswire/ ... announced that it will present preclinical and ... at the 2015 American Association for Cancer ... 18-22, 2015 at the Pennsylvania Convention Center in Philadelphia. The presentations ... engineering and nanoliposomal technology platforms, as well ...
(Date:3/26/2015)... , March 26, 2015 ... on the development of first-in-class products to induce ... that it closed an equity financing of shares ... approximately $22 million, including the conversion of approximately ... from the financing will be used to support ...
Breaking Medicine Technology:Alle abgebenden Apotheken berechtigt, um ab dem 1. April 2015 .Pharmacy-Domainnamen zu beantragen 2Merrimack to Highlight Extensive Oncology Pipeline at the 2015 American Association for Cancer Research Annual Meeting 2Merrimack to Highlight Extensive Oncology Pipeline at the 2015 American Association for Cancer Research Annual Meeting 3Gelesis Closes $22M Equity Financing 2Gelesis Closes $22M Equity Financing 3
Cached News: