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Diabetes drug improves metabolic changes associated with HIV combination therapy

study period, participants who received rosiglitazone were found to have a 20 percent improvement in insulin sensitivity, based on a standard test called an insulin clamp. Both physical measurements and CT scans showed that those on the active medication had significant increases in total body fat, particularly in their extremities. Peripheral fat measurements increased by 24 percent in the treatment group but decreased by 2 percent in the placebo group.

"We were able to demonstrate that this class of agents can slow down or reverse fat loss in patients with fat atrophy," says Hadigan. "However there are still a lot of questions to be answered about safety before these results can be widely applied. For example, those taking rosiglitazone had increases in both total and LDL cholesterol, but there were changes in other metabolic markers which might protect against cardiovascular disease. Larger and longer trials of this drug and related medications are needed to determine the best therapeutic approaches for individual patients." Hadigan is an assistant professor of pediatrics at Harvard Medical School.

Other authors of the Annals report are senior author Steven Grinspoon, MD, and Fiona Havers of the MGH Neuroendocrine Unit and Program in Nutritional Metabolism; and Sigal Yawetz, MD, Abraham Thomas, MD, and Paul Sax, MD, of Brigham and Women's Hospital. The study was supported by grants from the National Institutes of Health.


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Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
17-May-2004


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