HOME >> MEDICINE >> NEWS
Diabetes treatment linked to increased blood pressure in animal study

BOSTON A report in the July issue of the Journal of Clinical Investigation has found that a group of drugs currently under development for the treatment of Type II diabetes caused both increased heart rate and elevated blood pressure in animal studies.

These new findings regarding glucagon-like peptide (GLP-1) receptor agonists suggest that the brain's GLP-1 system has the ability to affect autonomic function, leading to changes in heart rate and blood pressure.

A naturally occurring hormone that is produced by cells lining the intestine, GLP-1 was first targeted as a diabetes treatment about 15 years ago, according to the study's senior author Joel Elmquist, D.V.M., Ph.D., a neuroscientist and endocrinologist at Beth Israel Deaconess Medical Center and Associate Professor of Neurology and Medicine at Harvard Medical School.

"GLP-1 stimulates insulin secretion and controls feeding and drinking behavior, and also regulates neuroendocrine responses to agents that elicit illness-like behaviors," he explains. "The effect on insulin secretion made the hormone an obvious target for treating diabetes."

Diabetes develops when the body fails to either produce or to properly use insulin, a hormone necessary to convert food including sugars and starches into energy. Type II diabetes accounts for the majority of cases of the disease, and is a huge public health problem: As many as 16 million individuals in the United States have Type II diabetes, which puts them at risk for a number of serious complications, including stroke and heart disease.

Although diabetes can often be controlled through diet, exercise and existing medications, the magnitude of the problem has given rise to the development of a number of new drugs to better manage the disease, including the GLP-1 agonists. These agents, which are currently being tested in clinical trials, work by targeting the rate of gastric emptying and by stimulating insulin secretion from islet cells in the
'"/>

Contact: Bonnie Prescott
bprescot@caregroup.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
10-Jul-2002


Page: 1 2

Related medicine news :

1. Diabetes a bigger heart disease risk for women than for men
2. Diabetes: A link between oral and overall health?
3. Diabetes among older adults imposed an estimated $133.5 billion cost in 1990s
4. Diabetes increases deaths among people 65 and older
5. Diabetes may be going unnoticed in many UK children
6. Diabetes drug improves metabolic changes associated with HIV combination therapy
7. Diabetes linked to increased risk of Alzheimers in long-term study
8. Diabetes patients skip medications to save money
9. Diabetes doubles risk of liver disease and liver cancer
10. Salk news: Diabetes first steps
11. Diabetes management improves when patients, doctors agree on treatment goals, UMHS study finds

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... , ... August 05, 2020 , ... ... the appointments of Kathleen Cruger as Director of Clinical Services and Myron Falchuk, ... company’s growth. , “ChronWell has achieved incredible growth as demand for ...
(Date:8/5/2020)... ... August 04, 2020 , ... Total Spectrum, a company of ... in Wisconsin, is delighted to announce the grand opening of their new ... center, Total Spectrum now proudly serves ten different locations across the Midwest. The ...
(Date:8/3/2020)... ... August 03, 2020 , ... WorkBook6 – a Tempe, Arizona-based ... The site provides a simple and efficient way for Americans over the age ... as an important expansion for the insurance marketing ecosystem, and a critical service ...
(Date:7/31/2020)... ... July 31, 2020 , ... ... new patients to The Dental Studio of Midland for groundbreaking laser dentistry ... a result, these patients are able to experience the many advantages of laser ...
(Date:7/22/2020)... CHICAGO (PRWEB) , ... July 22, 2020 , ... As part of August’s Children’s Eye ... Center for Children’s Vision and Eye Health at Prevent Blindness (NCCVEH) has released an ... Current National Issues 2nd Edition . The goal of the report is , ...
Breaking Medicine News(10 mins):
(Date:8/3/2020)... YORK (PRWEB) , ... August 03, 2020 , ... ... health and science innovations, today announced that Donna L. LaVoie, President, CEO and Founder ... in the life-sciences industry. , Since 2005, the PharmaVOICE 100 has honored more ...
(Date:7/31/2020)... , ... July 31, 2020 , ... Member Care Solutions ... nation’s largest urgent care clinic operators the licensing of their cloud based membership management ... Member Care Solutions client family. Our software is the perfect match for many reasons, ...
(Date:7/22/2020)... ... July 22, 2020 , ... TrialScope, the ... announce the addition of Moderna to its growing customer roster. , TrialScope customers ... for trial disclosure management, patient engagement and study recruitment. Collectively, TrialScope customers are ...
Breaking Medicine Technology:
Cached News: