HOME >> MEDICINE >> NEWS
Diabetes treatment linked to increased blood pressure in animal study

BOSTON A report in the July issue of the Journal of Clinical Investigation has found that a group of drugs currently under development for the treatment of Type II diabetes caused both increased heart rate and elevated blood pressure in animal studies.

These new findings regarding glucagon-like peptide (GLP-1) receptor agonists suggest that the brain's GLP-1 system has the ability to affect autonomic function, leading to changes in heart rate and blood pressure.

A naturally occurring hormone that is produced by cells lining the intestine, GLP-1 was first targeted as a diabetes treatment about 15 years ago, according to the study's senior author Joel Elmquist, D.V.M., Ph.D., a neuroscientist and endocrinologist at Beth Israel Deaconess Medical Center and Associate Professor of Neurology and Medicine at Harvard Medical School.

"GLP-1 stimulates insulin secretion and controls feeding and drinking behavior, and also regulates neuroendocrine responses to agents that elicit illness-like behaviors," he explains. "The effect on insulin secretion made the hormone an obvious target for treating diabetes."

Diabetes develops when the body fails to either produce or to properly use insulin, a hormone necessary to convert food including sugars and starches into energy. Type II diabetes accounts for the majority of cases of the disease, and is a huge public health problem: As many as 16 million individuals in the United States have Type II diabetes, which puts them at risk for a number of serious complications, including stroke and heart disease.

Although diabetes can often be controlled through diet, exercise and existing medications, the magnitude of the problem has given rise to the development of a number of new drugs to better manage the disease, including the GLP-1 agonists. These agents, which are currently being tested in clinical trials, work by targeting the rate of gastric emptying and by stimulating insulin secretion from islet cells in the
'"/>

Contact: Bonnie Prescott
bprescot@caregroup.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
10-Jul-2002


Page: 1 2

Related medicine news :

1. Diabetes a bigger heart disease risk for women than for men
2. Diabetes: A link between oral and overall health?
3. Diabetes among older adults imposed an estimated $133.5 billion cost in 1990s
4. Diabetes increases deaths among people 65 and older
5. Diabetes may be going unnoticed in many UK children
6. Diabetes drug improves metabolic changes associated with HIV combination therapy
7. Diabetes linked to increased risk of Alzheimers in long-term study
8. Diabetes patients skip medications to save money
9. Diabetes doubles risk of liver disease and liver cancer
10. Salk news: Diabetes first steps
11. Diabetes management improves when patients, doctors agree on treatment goals, UMHS study finds

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/25/2017)... ... 25, 2017 , ... SureVest Insurance Group, a locally managed ... North Carolina, is launching a charity event in conjunction with the Triangle Chapter ... fight against bladder cancer. , The Bladder Cancer Advocacy Network (BCAN) operates multiple ...
(Date:7/25/2017)... ... 2017 , ... Facing medical needs with a newborn boy this spring, ... new benefit for employees that is uncommon in American business: 12 weeks of fully ... and other employees as new parents. It keeps our family life more stable. I ...
(Date:7/24/2017)... Kansas City, MO (PRWEB) , ... July 24, 2017 , ... ... for the acclaimed Saint Luke’s Marion Bloch Neuroscience Institute (SLMBNI), part of ... an interim basis since 2016. , Cheerag D. Upadhyaya, MD. M.Sc., FAANS joins ...
(Date:7/24/2017)... ... July 24, 2017 , ... ... effectively destroyed the construction site and threatened numerous homes and businesses nearby, causing ... article on NBCLosAngeles.com. Los Angeles Area consulting firm Fire Protection Group, Inc. ...
(Date:7/24/2017)... , ... July 24, 2017 , ... ... media initiatives designed to promote awareness for Topricin’s revolutionary, natural, after-burn skin care ... one of the leading causes of long term skin conditions, including cancer. ...
Breaking Medicine News(10 mins):
(Date:7/13/2017)...  New York City-based market research firm Kalorama Information notes ... of.  From new products to new costs, to the threat ... completed study, Potential Pipeline Disruptors . Among ... 1.  Age-Driven Growth - True Impact Moment Arriving   ... impact the growing population and, to a more extreme extent, ...
(Date:7/11/2017)... 11, 2017  The global market for liquid biopsy ... $394.1 million in 2016.  Although in early stages, the ... in particular as a result of the gradual shift ... recent introduction of a significant number of new liquid ... of tumor biomarkers to guide treatment decisions. ...
(Date:7/10/2017)... July 10, 2017 The Institute for In ... is the recipient of a VITROCELL® inhalation exposure system ... Science Consortium. The device, which is designed to replace ... human lung cells to airborne test materials in an ... the VITROCELL® system for testing combustible tobacco products, as ...
Breaking Medicine Technology:
Cached News: