HOME >> MEDICINE >> NEWS
Diagnostic test for range of blood disorders on the horizon

Scientists have discovered a single mutation that is responsible for a number of blood disorders, reporting their findings in this week's issue of THE LANCET.

Myeloproliferative disorders form a range of haematological malignant diseases, with three main members: polycythaemia vera, essential thrombocythaemia, and idiopathic myelofibrosis. The disorders are characterised by overactive production of blood cells and can lead to thrombosis, haemorrhage or acute myeloid leukaemia. The absence of a definitive diagnostic test and the scarcity of randomised clinical trials make management of these diseases especially challenging.

Tony Green (Cambridge Institute for Medical Research, UK) and colleagues analysed a candidate gene called JAK2 in 140 patients with myeloproliferative disorders from haematological clinics in the UK. They also took control DNA samples from a population of patients with type 1 diabetes. A single point mutation was identified in the JAK2 gene in 71 (97%) of 73 patients with polycythaemia vera, 29 (57%) of 51 with essential thrombocythaemia, and eight (50%) of 16 with idiopathic myelofibrosis. The mutation was not detected in any of the controls.

Distinguishing myeloproliferative disorders from other blood disorders such as thrombocytosis can be difficult; the authors suggest the detection of the JAK2 mutation could become a widely used diagnostic test.

Professor Green concludes: "For more than a quarter of a century, the myeloproliferative disorders have been known to be clonal haematological malignancies, but the identity of underlying target genes has remained elusive. We have shown that a single acquired point mutation in JAK2 is present in virtually all patients with polycythaemia vera and in about half of those with either essential thrombocythaemia or idiopathic myelofibrosis. It is also important to acknowledge the work of several other research groups who have similar data submitted for publication. These e
'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
1-212-633-3810
Lancet
17-Mar-2005


Page: 1 2

Related medicine news :

1. Diagnostic imaging surge by non-radiologists draws concern
2. Diagnostic tests are more accurate than estimates suggest
3. Diagnostic method based on nanoscience could rival PCR
4. U of MN Vet Diagnostic Lab chosen by CDC as monkeypox testing site
5. New rapid anthrax test developed through collaboration between Mayo Clinic and Roche Diagnostics. Test, which provides results in less than one hour, will be made available to United States laboratories
6. Yale Medical Students Use Artwork To Sharpen Diagnostic Skills; Innovative Teaching Method Aims To Improve Observation Of Patients
7. Affordable, Hand-Held Biosensor For Diagnostics
8. Outstanding efficacy of Crestor (TM) in treating range of patient populations at risk of CVD
9. Rise in stranger homicides not linked to mental illness
10. Orange juice fortified with plant sterols found to lower bad cholesterol in healthy volunteers
11. New studies demonstrate importance of offering range of treatment options to elderly cancer patients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/8/2019)... ... 2019 , ... Intelligent.com, a trusted resource for online degree ... for 2020. The comprehensive research guide is based on an assessment of 104 ... curriculum quality, graduation rate, reputation, and post-graduate employment. , The 2020 rankings ...
(Date:12/6/2019)... ... December 06, 2019 , ... In a ... in Salt Lake Community College’s (SLCC) Emergency Medical Technician (EMT) Program—Maria ... Schaefer—were awarded the AT&T Public Safety Hero Scholarship to support their first responder ...
(Date:12/6/2019)... ... ... TIME For Kids (TFK) revealed the first-ever list of the World’s 50 ... are tailored to the interests of kids. The list identifies The Children’s Museum of ... for Kids gathered nominations from its network of TFK Kid Reporters and ...
(Date:12/5/2019)... ... December 05, 2019 , ... Intelligent.com, a trusted ... 54 RHIT Degree Programs for 2020. The comprehensive research guide is based on ... is evaluated based on curriculum quality, graduation rate, reputation, and post-graduate employment. ...
(Date:12/4/2019)... ... December 04, 2019 , ... WEDI , the nation’s leading nonprofit ... exchange and a trusted advisor to the U.S. Department of Health and Human Services ... announced during the 2019 WEDI Winter Conference in Arlington, Va. on Wednesday, December 4. ...
Breaking Medicine News(10 mins):
(Date:12/6/2019)... KENOSHA, Wis. (PRWEB) , ... December 06, 2019 ... ... for USP 800, targeted for implementation this month, Kenall is introducing the CSEDOIC ... be tightly controlled. USP 800 now requires the unpacking of hazardous drugs (HDs) ...
(Date:12/6/2019)... ... December 06, 2019 , ... Plant Life Company ... Supply LLC (a division of Horticultural Holdings LLC) to recommend Plant Life Company’s ... , FFGS is a team of disciplined and energetic plant lovers formally educated ...
(Date:12/4/2019)... MESA, Calif. (PRWEB) , ... December 04, 2019 , ... ... Mind and Medicine, an Orange County drug and alcohol rehab center and ... Program! Members of their team conducted street outreach, trained, and distributed Naloxone amongst members ...
Breaking Medicine Technology:
Cached News: