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Diet, exercise, stimulating environment helps old dogs learn

healthy lifestyle as the most beneficial approach. While we have yet to demonstrate these benefits in people, research such as this gives us new ways to think about the aging brain and what we can do to keep it intact."

For the study, the researchers divided 48 older beagles (ages 7 to 11) into four groups. One group was fed a regular diet and received standard care; a second group received standard care but was fed an antioxidant fortified diet, consisting of standard dog food supplemented with tomatoes, carrot granules, citrus pulp, spinach flakes, the equivalent of 800 IUs of vitamin E, 20 milligrams per kilogram of vitamin C, and two mitochondrial co-factors--lipoic acid and carnitine; the third was fed a regular diet, but their environment was enriched (regular exercise, socialization with other dogs, and access to novel toys); the fourth group received a combination of the antioxidant diet as well as environmental enrichment. In addition, a set of 17 young dogs (ages 1 to 3) were divided into two groups, one fed a regular diet and the other fed the antioxidant fortified diet.

The fruits and vegetables added to the antioxidant fortified diet was the equivalent of increasing intake from 3 servings to 5 or 6 servings daily. Previous research suggests that antioxidants might reduce free radical damage to neurons in the brain, which scientists believe is involved in age-associated learning and memory problems. Mitochondrial co-factors may help neurons function more efficiently, slash free radical production and lead to improvements in brain function. Other studies suggest that stimulating environments improve learning ability, induce beneficial changes in cellular structure, may help the brain grow new neurons, and increase the resistance of neurons to injury.

As the study progressed, researchers tested the dogs with a series of increasingly difficult learning problems, including a task in which the animals needed to learn whether a treat
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Contact: Doug Dollemore
dollemod@nia.nih.gov
301-496-1752
NIH/National Institute on Aging
18-Jan-2005


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