HOME >> MEDICINE >> NEWS
Dietary bioflavonoids induce DNA breaks, may contribute to infant leukemia

at the cause may be an infectious agent, but epidemiologic studies have suggested that maternal consumption of foods such as bioflavonoids could lead to an increased risk of infant leukemia. A 1988 study found the disease to be nearly twice as common in several large Asian cities, where soy intake is two to five times as high as in the U.S.

The researchers, using blood and bone marrow cells from healthy newborns and adults, as well as leukemic cell lines, were able to determine the mechanism of DNA damage. The bioflavonoids, like the drugs VP16 and Dox, inhibit the action of an enzyme known as topoisomerase II (topo II), which helps to cleave apart and then rejoin strands of DNA, a process that is pivotal for various cell functions.

Leukemia can result when these normal DNA breaks are not properly reconnected, part of topo-II's mission.

MLL is a promiscuous gene. Once broken, it can reconnect with any of more than 40 other genes in a translocation, a process that involves an exchange of DNA between two chromosomes. Extensive recombinations usually cause cell death; but subtle translocations involving MLL can result in the rapid, uncontrolled cell division seen in leukemia.

Interestingly, cancerous cell lines that had developed resistance to drugs like VP16 and Dox were not susceptible to bioflavonoid DNA breaks.

Certain types of bioflavonoids, especially the flavonols, were more powerful topo-II inhibitors than others. For example, two different forms of quercetin, a dietary supplement, and fisetin, which is derived from herbs, were equal to VP16 in triggering MLL cleavage. Combinations of these substances demonstrated a cumulative effect.

Another group, the flavanones, found in citrus fruits, did not induce MLL cleavage.

"The public health message from this study is not yet clear," said Janet Rowley, M.D., Blum-Reise Distinguished Service Professor in the departments of medicine, molecular genetics & cell biology, a
'"/>

Contact: John Easton
jeaston@uchospitals.edu
773 702 6241
University of Chicago Medical Center
10-Apr-2000


Page: 1 2 3

Related medicine news :

1. National Academies Advisory: April 1 Public Briefing on Safety of Dietary Supplements
2. Dietary supplements containing ephedra and caffeine may cause heart problems
3. Dietary fats may increase the risk of age-related macular degeneration
4. Dietary fat not linked to risk of stroke
5. Dietary supplement and flu vaccines
6. Dietary intake of vitamin E may reduce risk of Parkinsons disease
7. Dietary change may prevent the most serious form of prostate cancer
8. Dietary whole grains may benefit in prevention and treatment of type 2 diabetes
9. Examining The Science Behind Nutraceuticals: Proceedings of the AAPS Dietary Supplements Forum
10. American Association of Pharmaceutical Scientists Dietary Supplements Forum examines science behind nutraceuticals
11. First Evidence Found Of Link Between Gum Disease And High Alcohol Consumption, Low Dietary Antioxidants

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the Law ... organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our ... a forum to network with elder law attorneys nationwide,” said Somekh. , ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills ... specialty vendors and unique items from across the nation, this holiday-themed event will raise ... offered by the VNA. The boutique will be open Saturday, November 4 (10:00 ...
(Date:10/13/2017)... ... 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, ... and least understood books in the Holy Scriptures, Revelation. The Book of Revelation paints ... for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins says ...
(Date:10/13/2017)... ... ... Journey: From the Mountains to the Mission Field”: the story of a missionary couple ... From the Mountains to the Mission Field” is the creation of published author, Carole ... and currently teaches a class of ladies at her church, which she has taught ...
(Date:10/12/2017)... Francisco, CA (PRWEB) , ... October 12, 2017 ... ... Dr. Cheng, are now treating sleep apnea using cutting-edge Oventus O2Vent ... apnea, a serious sleep disorder characterized by frequent cessation in breathing. Oral appliances ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... , Oct. 6, 2017   Provista, ... more than $100 billion in purchasing power, today announced ... and information. The Newsroom is the online ... industry trends, infographics, expert bios, news releases, slideshows and ... access to a wealth of resources at their fingertips, ...
(Date:10/4/2017)... to the Centers for Disease Control and Prevention (CDC), influenza vaccination ... is helping communities across Massachusetts , Connecticut ... flu shots through the end of the month. *Some exclusions ... ... shot is by the end of October, according to the Centers for ...
(Date:10/2/2017)... Lilly and Company (NYSE: LLY ) will ... 2017 on Tuesday, October 24, 2017. Lilly will also ... investment community and media to further detail the company,s ... at 9 a.m. Eastern time. Investors, media and the ... conference call through a link that will be posted ...
Breaking Medicine Technology:
Cached News: