HOME >> MEDICINE >> NEWS
Dietary bioflavonoids induce DNA breaks, may contribute to infant leukemia

at the cause may be an infectious agent, but epidemiologic studies have suggested that maternal consumption of foods such as bioflavonoids could lead to an increased risk of infant leukemia. A 1988 study found the disease to be nearly twice as common in several large Asian cities, where soy intake is two to five times as high as in the U.S.

The researchers, using blood and bone marrow cells from healthy newborns and adults, as well as leukemic cell lines, were able to determine the mechanism of DNA damage. The bioflavonoids, like the drugs VP16 and Dox, inhibit the action of an enzyme known as topoisomerase II (topo II), which helps to cleave apart and then rejoin strands of DNA, a process that is pivotal for various cell functions.

Leukemia can result when these normal DNA breaks are not properly reconnected, part of topo-II's mission.

MLL is a promiscuous gene. Once broken, it can reconnect with any of more than 40 other genes in a translocation, a process that involves an exchange of DNA between two chromosomes. Extensive recombinations usually cause cell death; but subtle translocations involving MLL can result in the rapid, uncontrolled cell division seen in leukemia.

Interestingly, cancerous cell lines that had developed resistance to drugs like VP16 and Dox were not susceptible to bioflavonoid DNA breaks.

Certain types of bioflavonoids, especially the flavonols, were more powerful topo-II inhibitors than others. For example, two different forms of quercetin, a dietary supplement, and fisetin, which is derived from herbs, were equal to VP16 in triggering MLL cleavage. Combinations of these substances demonstrated a cumulative effect.

Another group, the flavanones, found in citrus fruits, did not induce MLL cleavage.

"The public health message from this study is not yet clear," said Janet Rowley, M.D., Blum-Reise Distinguished Service Professor in the departments of medicine, molecular genetics & cell biology, a
'"/>

Contact: John Easton
jeaston@uchospitals.edu
773 702 6241
University of Chicago Medical Center
10-Apr-2000


Page: 1 2 3

Related medicine news :

1. National Academies Advisory: April 1 Public Briefing on Safety of Dietary Supplements
2. Dietary supplements containing ephedra and caffeine may cause heart problems
3. Dietary fats may increase the risk of age-related macular degeneration
4. Dietary fat not linked to risk of stroke
5. Dietary supplement and flu vaccines
6. Dietary intake of vitamin E may reduce risk of Parkinsons disease
7. Dietary change may prevent the most serious form of prostate cancer
8. Dietary whole grains may benefit in prevention and treatment of type 2 diabetes
9. Examining The Science Behind Nutraceuticals: Proceedings of the AAPS Dietary Supplements Forum
10. American Association of Pharmaceutical Scientists Dietary Supplements Forum examines science behind nutraceuticals
11. First Evidence Found Of Link Between Gum Disease And High Alcohol Consumption, Low Dietary Antioxidants

Post Your Comments:
(Date:10/20/2014)... York, NY (PRWEB) October 20, 2014 ... be introduced in the U.S., has a lot to celebrate ... when our country recognizes the achievements and contributions of Americans ... the anniversary for Punzoné, and today it shares its favorite ... take a trip to Italy - even if it is ...
(Date:10/20/2014)... 20, 2014 Do you ever feel ... comes a wonderful app Metassessor for teachers, specialists and ... helped its client “Intervention Development LLC” to launch ... is designed for iOS 4.3 or later and is ... is optimized for iPhone 5. It is now available ...
(Date:10/19/2014)... The leading review website, Top10BestSEOHosting.com, has recently announced ... the best Dedicated Server Hosting suppliers. Their websites ... buy high quality hosting and save money at ... Top10BestSEOHosting.com says, “We believe that iPage and GreenGeeks ... lot of the global clients enjoy using their ...
(Date:10/19/2014)... UNITED NATIONS, New York (PRWEB) October 19, 2014 ... the United Nations Population Fund, welcomes news of a ... release of the more than 200 girls who were ... Girls. "These girls have languished in captivity long enough, ... their families, schools and communities," stated Dr. Osotimehin. , ...
(Date:10/19/2014)... October 20, 2014 Having been working in ... good knowledge of customer needs. According to James, one of ... with dazzling sequins, or with high-low skirts that add beauty ... huge demand. Recently, LunaDress has unveiled its new selection of ... fact, the company’s brand new items are available in over ...
Breaking Medicine News(10 mins):Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 2Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 3Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 4Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 2Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 3Health News:Top10BestSEOHosting.com Considers iPage And GreenGeeks As The Best Dedicated Server Hosting Suppliers 2Health News:2014 Long Prom Dresses From LunaDress Now Available In Over 20 Popular Designs 2
(Date:10/19/2014)... Shire plc (LSE: SHP, NASDAQ: SHPG ) announces ... notified the Board of Directors of his decision to step down ... CFO of Severn Trent plc.  James will leave Shire at the ... for a new CFO immediately. Flemming Ornskov, Shire,s Chief ... a high-quality finance team at Shire. We are very grateful to ...
(Date:10/18/2014)... , Oct. 18, 2014  In a ... Rights Campaign (HRC), the nation,s largest lesbian, gay, ... endorsed the use of Truvada for Pre-Exposure Prophylaxis ... tool used to prevent the spread of a ... the only brand name anti-HIV drug combination currently ...
(Date:10/17/2014)... THOUSAND OAKS, Calif. , Oct. 17, 2014 /PRNewswire/ ... appointment of R. Sanders Williams , M.D., president ... L. Mahley Distinguished Professor.  "We are ... the Amgen Board," said Robert A. Bradway , ... deep and distinguished experience in academic medicine and his ...
Breaking Medicine Technology:Interim Chief Financial Officer James Bowling to Step Down 2Interim Chief Financial Officer James Bowling to Step Down 3Interim Chief Financial Officer James Bowling to Step Down 4HRC Endorses PrEP, Calls for Bold Action to Expand Access to Anti-HIV Drug 2HRC Endorses PrEP, Calls for Bold Action to Expand Access to Anti-HIV Drug 3Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 2Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 3
Cached News: