HOME >> MEDICINE >> NEWS
Dietary bioflavonoids induce DNA breaks, may contribute to infant leukemia

at the cause may be an infectious agent, but epidemiologic studies have suggested that maternal consumption of foods such as bioflavonoids could lead to an increased risk of infant leukemia. A 1988 study found the disease to be nearly twice as common in several large Asian cities, where soy intake is two to five times as high as in the U.S.

The researchers, using blood and bone marrow cells from healthy newborns and adults, as well as leukemic cell lines, were able to determine the mechanism of DNA damage. The bioflavonoids, like the drugs VP16 and Dox, inhibit the action of an enzyme known as topoisomerase II (topo II), which helps to cleave apart and then rejoin strands of DNA, a process that is pivotal for various cell functions.

Leukemia can result when these normal DNA breaks are not properly reconnected, part of topo-II's mission.

MLL is a promiscuous gene. Once broken, it can reconnect with any of more than 40 other genes in a translocation, a process that involves an exchange of DNA between two chromosomes. Extensive recombinations usually cause cell death; but subtle translocations involving MLL can result in the rapid, uncontrolled cell division seen in leukemia.

Interestingly, cancerous cell lines that had developed resistance to drugs like VP16 and Dox were not susceptible to bioflavonoid DNA breaks.

Certain types of bioflavonoids, especially the flavonols, were more powerful topo-II inhibitors than others. For example, two different forms of quercetin, a dietary supplement, and fisetin, which is derived from herbs, were equal to VP16 in triggering MLL cleavage. Combinations of these substances demonstrated a cumulative effect.

Another group, the flavanones, found in citrus fruits, did not induce MLL cleavage.

"The public health message from this study is not yet clear," said Janet Rowley, M.D., Blum-Reise Distinguished Service Professor in the departments of medicine, molecular genetics & cell biology, a
'"/>

Contact: John Easton
jeaston@uchospitals.edu
773 702 6241
University of Chicago Medical Center
10-Apr-2000


Page: 1 2 3

Related medicine news :

1. National Academies Advisory: April 1 Public Briefing on Safety of Dietary Supplements
2. Dietary supplements containing ephedra and caffeine may cause heart problems
3. Dietary fats may increase the risk of age-related macular degeneration
4. Dietary fat not linked to risk of stroke
5. Dietary supplement and flu vaccines
6. Dietary intake of vitamin E may reduce risk of Parkinsons disease
7. Dietary change may prevent the most serious form of prostate cancer
8. Dietary whole grains may benefit in prevention and treatment of type 2 diabetes
9. Examining The Science Behind Nutraceuticals: Proceedings of the AAPS Dietary Supplements Forum
10. American Association of Pharmaceutical Scientists Dietary Supplements Forum examines science behind nutraceuticals
11. First Evidence Found Of Link Between Gum Disease And High Alcohol Consumption, Low Dietary Antioxidants

Post Your Comments:
(Date:12/20/2014)... 20, 2014 Today, Balfleet.com, one of ... Christmas Sale, offering 50%-70% off on its Mother ... , The mother of the bride dresses from Balfleet.com ... is 24/7 accessible and takes pride in providing high ... “We are offering great discounts on our mother of ...
(Date:12/19/2014)... It’s very easy to become overwhelmed with the holidays ... the wayside until Christmas and the New Year are over. ... that burning desire to just escape it all and get ... Telluride with a no-fuss, affordable package. Montrose Days Inn will ... and ensure that all accommodations are met. Plus, everyone has ...
(Date:12/19/2014)... Florida (PRWEB) December 19, 2014 Sub Zero ... to sponsor a blood drive Sunday the 28th from 2pm-6pm ... Road & Sawyer Road in Sarasota, FL. , Inquiries regarding ... thank you for participating in the donating process, Sub Zero ... free flash frozen, custom ice cream. , About Sub Zero ...
(Date:12/19/2014)... (PRWEB) December 19, 2014 ... dedicated to developing educational events, tools and resources ... Rouxbe Cooking School , the world’s leading online ... prescription every human being needs: Culinary Rx. As ... cooking course, Culinary Rx, scheduled for debut spring ...
(Date:12/19/2014)... Santa Rosa, CA (PRWEB) December 19, 2014 ... 2x4 and 5x5 SuperClone Rooms. SuperCloset continues to offer ... grow solutions. Pair one of the new SuperClone Rooms ... truly professional, perpetual, and turnkey indoor hydroponic grow room ... cloner in the world, SuperCloset’s SuperPonic SuperCloner 50 ...
Breaking Medicine News(10 mins):Health News:Balfleet.com is Offering 50%-70% Off of its Mother of the Bride Dresses 2Health News:Days Inn Montrose Colorado Delivers Last Minute Holiday Season Ski Getaway Accommodations 2Health News:Shark Tank’s Sub Zero Ice Cream Sponsors Blood Drive 2Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 2Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 3Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 4Health News:SuperCloset Continues to Innovate with New Complete Indoor Grow Room Packages, The SuperClone Rooms are the Newest Addition to the Award Winning SuperRoom Lineup 2
(Date:12/19/2014)... 19, 2014  Newport Corporation (NASDAQ: ... has joined the company,s Board of Directors.  Dr. ... a director of Evans Analytical Group, a leading ... analytical services to companies in a wide range ... Evans Analytical Group, Dr. Kadia spent nine years ...
(Date:12/19/2014)... 2014 Breckenridge Pharmaceutical, Inc. announced today that ... Laboratories Pvt. Ltd. ( Hyderabad, India ) ... new ANDAs.  Under the terms of the agreement, MSN ... Breckenridge for the U.S. market, and Breckenridge will market ... MSN have agreed to develop an oral antibiotic with ...
(Date:12/19/2014)... , Dec. 19, 2014 In ... research and marketing communication tools are essential for ... competitive – consequently consumers, desires, preferences, and unmet ... environment, market research groups across all industries are ... communication tools. However, the adoption of new market ...
Breaking Medicine Technology:Siddhartha Kadia, Ph.D. Joins Board of Directors of Newport Corporation 2Breckenridge Pharmaceutical signs Multi-Product Generic Agreement with MSN Laboratories Pvt. Ltd. 2Study Uncovers New Tools and Techniques for Understanding Consumer Decision Making 2
Cached News: