HOME >> MEDICINE >> NEWS
Differences in human brain chemistry may account for different responses to,,stimulants

Scientists have discovered a mechanism that appears to account for the different levels of euphoria people experience when taking a stimulant drug, according to a new study funded by the National Institute on Drug Abuse (NIDA) and the U.S. Department of Energy. The study, which will appear in the September issue of the American Journal of Psychiatry, found that people who have lower levels of dopamine D2 receptors in their brains are more inclined to like the effects of methylphenidate, a mild stimulant, than people who have higher levels of these receptors and who were found to dislike the drug's effects.

"This finding supports the theory that brain chemistry may predispose some people to becoming drug abusers," says NIDA Director Dr. Alan I. Leshner. "Understanding these biological issues will help us learn why some people are particularly vulnerable to abusing drugs and provides new potential targets for both prevention and treatment efforts."

In the study, Dr. Nora Volkow and her colleagues at Brookhaven National Laboratory in Upton, New York, and at the State University of New York at Stony Brook used a brain imaging technique called positron emission tomography to measure dopamine D2 receptor, or D2, levels in the brains of 23 men who were not drug abusers. The men were given methylphenidate and asked to describe its effects.

Twelve of the men described methylphenidate as pleasant, saying that the drug made them happy or improved their mood. Nine described the drug as unpleasant, saying that it made them annoyed or distrustful, and two described the drug as neutral in its effects.

The results of this study showed that those who described methylphenidate's effects as pleasant had lower numbers of D2 receptors than did those who described the drug's effects as unpleasant. "The fact that the people in the current study who liked methylphenidate also had low levels of these receptors and yet were not stimulant abusers indicates that o
'"/>

Contact: Beverly Jackson or Michelle Muth
mm488g@nih.gov
301-443-6245
NIH/National Institute on Drug Abuse
1-Sep-1999


Page: 1 2

Related medicine news :

1. Differences in cancer screening rates reported
2. Differences in brain function make it hard for people with schizophrenia to interpret other peoples feelings
3. Sex Differences Found In Proportions Of Gray And White Matter In The Brain: Links To Differences In Cognitive Performance Seen
4. ALA/ATS Meeting Explores Gender Differences In Smoking And Lung Transplant Outcomes And Heart Attack Risk From Asthma Medication
5. Differences In Brain Function Found For Attention Deficit Disorder
6. Study Reveals Possible Clue For Racial Differences In Prevalence Of High Blood Pressure
7. UIC professor receives international humanitarian award
8. UCSF study offers insight into human circadian rhythms
9. Hopkins begins human trials with donor adult stem cells to repair muscle damaged from heart attack
10. Protecting human subjects focus of national FDA conference at UH
11. Test could improve detection of prion disease in humans

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/9/2019)... ... November 09, 2019 , ... On Monday, DOROT was featured in a ... disabled 64-year-old New Yorker who recently faced homelessness. A call to 311 eventually connected ... she found a new home in an assisted-living facility in Brooklyn. , DOROT alleviates ...
(Date:11/7/2019)... ... 2019 , ... , Entomol’s safe and effective, EPA-approved all-natural insect repellent ... 4 and a 7 hour formulations. , “Entomol helps people live healthier lives by ... and Encephalitis, without exposing them to the harmful chemicals found in other repellents,” said ...
(Date:11/6/2019)... ... November 06, 2019 , ... Nellson, LLC (Nellson), a ... powder solutions, recently achieved FSSC 22000 Certification of GFSA standard scheme at their ... the news that we have achieved FSSC 22000 compliance at our Salt Lake ...
(Date:11/6/2019)... ... ... Heritage Woods of Dwight is celebrating 10 years of service to area ... on Nov. 7. , “Since the beginning, Heritage Woods of Dwight has established itself ... Solutions, the company that manages the community. “With the opportunity for seniors to live ...
(Date:11/5/2019)... Mich. (PRWEB) , ... November 05, 2019 , ... ... am-2 pm. Call Jane at 616-575-9990 to schedule your appointment. All treatment available ... Cervical Advocates) health care medical bills. His books (What Time Tuesday?) available free ...
Breaking Medicine News(10 mins):
(Date:11/11/2019)... , ... November 11, 2019 , ... The Advocator Group, ... Top 100 Women-Led Businesses in Massachusetts as published in the Boston Globe Magazine. This ... Julie Turpin, who has held this position since 2014. , The rankings for ...
(Date:11/11/2019)... ... November 10, 2019 , ... A gifted actor and ... leading health management tools on an episode of "Behind The Scenes." The growth of ... of patients by the medical staff. This segment will focus on which tools are ...
(Date:11/11/2019)... ... ... Dr. Todd M. Britten and the team at Britten Periodontics & Implant Dentistry held their ... that dental coverage for veterans for major dental surgery can be very hard to attain, ... many veterans as they could. Dr. Britten says he owes the success of the event ...
Breaking Medicine Technology:
Cached News: