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Direct link found between chronic inflammation, colon cancer

Investigators in the A.B. Hancock Jr. Memorial Research Center at Vanderbilt have identified a type of DNA damage caused by chronic inflammation as a potential risk factor for colorectal cancer.

The findings, published this week in the early online edition of the website of the Proceedings of the National Academy of Science (www.pnas.org), shed more light on the role that inflammation might play in cancer and suggests that measurement of this type of DNA damage might be useful in assessment and management of a patient's colorectal cancer risk.

"A number of studies have implicated chronic inflammation in the development of cancers, but the specific way that occurs is not clear," said Dr. Lawrence J. Marnett, Ph.D., director of the Hancock Research Center and the Vanderbilt Institute of Chemical Biology.

"These studies suggest a direct link between oxidative stress, like that seen in chronic inflammation, and genetic mutations that cause human disease."

The work reported in PNAS builds on years of research at Vanderbilt into how overproduction of the inflammation-causing enzyme cyclooxygenase-2 (COX-2) may contribute to cancer and conversely, how aspirin-like drugs that block COX-2 might help treat or prevent cancer.

"When the body experiences oxidative stress, molecules called free radicals are produced, and these free radicals can damage cells the cell membrane and the DNA," Marnett said.

The researchers examined a type of DNA damage caused by malondialdehye (MDA), a product of COX-2. The question they wanted to answer was whether the DNA damage would stop with the damaged cell or whether it would cause genetic abnormalities, or mutations, which would be replicated in future cell lines.

They built a DNA molecule that incorporated the MDA-caused damage and inserted that into mammalian kidney cells. After the cells divided, the DNA was recovered from the ne
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Contact: Cynthia Floyd Manley or Clinton Colmenares
cynthia.manley@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
4-Nov-2003


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