HOME >> MEDICINE >> NEWS
Discovery Hints At Multitude Of New Targets For Drugs

DURHAM, N.C. -- A new study of how drugs plug into the human progesterone receptor in the cell supports a new and different view of how drugs and hormones act on steroid hormone receptors that trigger cellular responses.

The new view holds that steroid receptors are not merely on-off switches, but are far more complicated molecular "control panels" that could be manipulated by drugs customized to produce more targeted effects on the body, said the scientists who made the discovery. The drugs could cause the same receptor to trigger only certain of its normal effects in the body, but not others.

The finding, if confirmed, could point the way to a new wave of drugs with fewer side effects for contraception, hormone replacement therapy, breast and prostate cancer, inflammation, osteoporosis and endometriosis, said the researchers.

The scientists published their findings in the Aug. 6 issue of the Proceedings of the National Academy of Sciences. They are Brandee Wagner, Giuseppe Pollio and Donald McDonnell of the Duke University Medical Center departments of pharmacology and molecular cancer biology; Mansukh Wani, David Lee and C. Edgar Cook of the Research Triangle Institute (RTI), and Susan Leonhardt and Dean Edwards of the University of Colorado Health Science Center department of pathology. Their research was supported by the U.S. Public Health Service.

The researchers used living cells and test tube preparations to analyze how a range of compounds known to plug into the progesterone receptor affected its action.

Compounds that plug into receptors are known as ligands. Steroid receptors are complex proteins that are the principal switches activating cellular responses to steroid hormones. Steroid receptors reside deep in the cell's nucleus, activating genes that produce cellular responses. When a hormone or drug plugs into a receptor, that action changes the shape, or conforma
'"/>

Contact: Karyn George
georg016@mc.duke.edu
919-660-1301
Duke University
20-Aug-1996


Page: 1 2 3 4

Related medicine news :

1. Discovery of pathway in learning impairment caused by liver disease may lead to drug treatment
2. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
3. Discovery of the oldest remains of a woman who died in childbirth
4. Discovery sheds light on how cancer cells grow and divide
5. Discovery changes ideas about damage from strokes
6. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003
7. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003
8. GlaxoSmithKline Drug Discovery and Development Award 2002
9. Discovery may lead to new HIV drugs, says Jefferson virologist
10. GlaxoSmithKline Drug Discovery and Development Award 2002
11. "Radical" Discovery Advances Medicine and Plastics

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... August 31, 2020 , ... Smile ... dental groups in the United States, today announced the grand opening of another ... , Patients will enjoy convenient hours, a comfortable office, and full-service care ...
(Date:8/31/2020)... ... 2020 , ... Dr. Chang has over 20 years of ... developmental disabilities, as well as supporting staff in caring for patients and families. ... and staff development. She joined the company in 2015 as Chief of Clinical ...
(Date:8/28/2020)... ... August 28, 2020 , ... WHAT , Hespiro™ ... patients with respiratory conditions, including COVID-19, while reducing the need for scarce mechanical ... captures exhaled gas and scrubs it free of carbon dioxide in a completely ...
(Date:8/28/2020)... , ... August 28, 2020 , ... ... in advising Adventist Health on its investment in Synchronous Health, a tech-enabled behavioral ... that combines the strength of human empathy with artificial intelligence (AI) to increase ...
(Date:8/27/2020)... ... 2020 , ... Evolution Labs announced today that Florida Virtual ... Suite360:Mental Health and Prevention, a program developed to help students navigate a range ... Florida schools and districts must provide their students with preventative lessons after recent ...
Breaking Medicine News(10 mins):
(Date:8/27/2020)... , ... August 27, 2020 , ... The flu season is right round the corner ... well equipped with all the necessary measures before it begins to harbor its effects on ... and it is leaving a huge impact on our lives. Hence it has become even ...
(Date:8/26/2020)... , ... August 26, 2020 , ... ... Chiropractic Care Helps Sports Injuries. The infographic breaks down ways that chiropractors can ... healthier recovery. , According to ScripHessco “Athletes have an unusual amount of pressure ...
(Date:8/26/2020)... , ... August 26, 2020 , ... As the U.S. ... the daily routine for preventing the Coronavirus. Wear a mask, keep your distance, wash ... advocate Dr. Denis Burkitt said it best in 1977, “How much better it is ...
Breaking Medicine Technology:
Cached News: