HOME >> MEDICINE >> NEWS
Discovery Hints At Multitude Of New Targets For Drugs

tion, of the receptor. Previously, most scientists believed that this conformational change could only produce an on-off response.

Some of the new findings supported that early view. The researchers found that some of the test compounds were "agonists" of the receptor, switching it on. And others were "antagonists," blocking its action.

However, surprisingly, they discovered a new class of compounds that behaved differently from either of the first two classes. The compounds functioned as agonists in some cellular contexts, but as antagonists in others.

Discovery of this third class has broad clinical implications, said Donald McDonnell, an associate professor of pharmacology in the Duke medical center. The finding extends earlier work in his laboratory showing that the estrogen receptor, a distinctly different kind of steroid receptor, also shows similar mulitple modes of interaction with drugs or hormones.

"The discovery of such complexity in one receptor type is a phenomenon; the discovery of two is a paradigm," said McDonnell. "It's likely that these findings will extend to other receptors, such as the male androgen receptor," he said.

According to McDonnell, the discovery of new ways to affect such receptors could produce significant changes in the strategies by which pharmacologists seek new drugs to modulate them.

"To target drugs to one body tissue, pharmacologists have traditionally looked for subtypes of a receptor unique to that tissue," he said. "They could then design compounds that would select one or another subtype. But if there was only one kind of receptor, they were stuck.

"But now, our laboratory and others are showing that different compounds acting through the same receptor can manifest different biologies in different cells. We believe this extremely exciting realization will bring the next wave in the understanding of hormone a
'"/>

Contact: Karyn George
georg016@mc.duke.edu
919-660-1301
Duke University
20-Aug-1996


Page: 1 2 3 4

Related medicine news :

1. Discovery of pathway in learning impairment caused by liver disease may lead to drug treatment
2. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
3. Discovery of the oldest remains of a woman who died in childbirth
4. Discovery sheds light on how cancer cells grow and divide
5. Discovery changes ideas about damage from strokes
6. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003
7. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003
8. GlaxoSmithKline Drug Discovery and Development Award 2002
9. Discovery may lead to new HIV drugs, says Jefferson virologist
10. GlaxoSmithKline Drug Discovery and Development Award 2002
11. "Radical" Discovery Advances Medicine and Plastics

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/3/2016)... ... May 03, 2016 , ... Sandbox, one of the nation’s ... in the newly created position of executive vice president, chief creative officer.     , ... the Chicago and LA offices. He reports to Nancy Finigan, president of those ...
(Date:5/3/2016)... ... May 03, 2016 , ... ... pharmacies, will be represented at the 2016 Asembia Specialty Pharmacy Summit held May ... is the largest U.S. health care conference for the specialty pharmacy industry, with ...
(Date:5/3/2016)... ... May 03, 2016 , ... ... been selected by Tidelands Health, a three hospital system in South Carolina, to ... on the lookout for technology that enhances communication, drives workflow efficiencies and improves ...
(Date:5/3/2016)... ... 03, 2016 , ... Nationally recognized personal injury law firm Monge & Associates is ... to anyone who wants one for their Mother or any other mother figure. , According ... of Mothers.” Monge goes on to say, “we are choosing to do this by ...
(Date:5/3/2016)... ... , ... Ogawa World USA introduced the first of its kind Ogawa ... Application. The Smart 3D combines the best in technological advancement, design, and massage capability ... specialized massage program, each user has a tailored experience unparalleled by any other massage ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)...   BIOTRONIK will be exhibiting and initiating ... implant at the Heart Rhythm Society,s 37 th ... Francisco . "Physicians and hospitals ... patient care and satisfaction possible. Part of that process ... tomorrow," said Marlou Janssen , President, BIOTRONIK, Inc. ...
(Date:5/3/2016)... According to market research "Global ... and Demand Forecast to 2022 - Industry Insights by ... Very High Field, Low to Mid Field, and Ultra ... Musculoskeletal, Vascular, Breast, Pelvic and Abdomen, Cardiac, and Other)" ... market was valued at $5,351.7 million in 2015, and ...
(Date:5/3/2016)... -- Forté Elements, LLC (Forté) is excited to announce the launch of its Mediceutical line ... of recovery for a variety of clinical conditions. Founded in 2013, Forté spent more ... Logo -  http://photos.prnewswire.com/prnh/20160502/362547LOGO ... ... ...
Breaking Medicine Technology:
Cached News: