HOME >> MEDICINE >> NEWS
Discovery Hints At Multitude Of New Targets For Drugs

tion, of the receptor. Previously, most scientists believed that this conformational change could only produce an on-off response.

Some of the new findings supported that early view. The researchers found that some of the test compounds were "agonists" of the receptor, switching it on. And others were "antagonists," blocking its action.

However, surprisingly, they discovered a new class of compounds that behaved differently from either of the first two classes. The compounds functioned as agonists in some cellular contexts, but as antagonists in others.

Discovery of this third class has broad clinical implications, said Donald McDonnell, an associate professor of pharmacology in the Duke medical center. The finding extends earlier work in his laboratory showing that the estrogen receptor, a distinctly different kind of steroid receptor, also shows similar mulitple modes of interaction with drugs or hormones.

"The discovery of such complexity in one receptor type is a phenomenon; the discovery of two is a paradigm," said McDonnell. "It's likely that these findings will extend to other receptors, such as the male androgen receptor," he said.

According to McDonnell, the discovery of new ways to affect such receptors could produce significant changes in the strategies by which pharmacologists seek new drugs to modulate them.

"To target drugs to one body tissue, pharmacologists have traditionally looked for subtypes of a receptor unique to that tissue," he said. "They could then design compounds that would select one or another subtype. But if there was only one kind of receptor, they were stuck.

"But now, our laboratory and others are showing that different compounds acting through the same receptor can manifest different biologies in different cells. We believe this extremely exciting realization will bring the next wave in the understanding of hormone a
'"/>

Contact: Karyn George
georg016@mc.duke.edu
919-660-1301
Duke University
20-Aug-1996


Page: 1 2 3 4

Related medicine news :

1. Discovery of pathway in learning impairment caused by liver disease may lead to drug treatment
2. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
3. Discovery of the oldest remains of a woman who died in childbirth
4. Discovery sheds light on how cancer cells grow and divide
5. Discovery changes ideas about damage from strokes
6. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003
7. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003
8. GlaxoSmithKline Drug Discovery and Development Award 2002
9. Discovery may lead to new HIV drugs, says Jefferson virologist
10. GlaxoSmithKline Drug Discovery and Development Award 2002
11. "Radical" Discovery Advances Medicine and Plastics

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Discovery Hints Multitude New Targets For Drugs

(Date:7/30/2014)... LTC Consumer, an independent, free online service ... features an Instant Quote tool on its website, LTCconsumer.com ... Consumer. Quotes are free and unlimited. , The Instant ... areas – including age, gender, and state of residence – ... don’t need to enter any contact information to get started). ...
(Date:7/30/2014)... 2014 As the controversy surrounding the ... surgeries continues to grow, Bernstein Liebhard LLP notes that ... for a ban on uterine morcellation. According to a ... with leiomyosarcoma following a hysterectomy that involved the use ... diagnosis, the aggressive cancer had progressed to Stage 4. ...
(Date:7/30/2014)... DC (PRWEB) July 30, 2014 ... appreciation to U.S. Sens. Thad Cochran (R-MS) and ... for improvements in telemedicine coverage under Medicare, Medicaid ... and Wicker, both Mississippi Republicans, introduced the Telehealth ... to a House version, H.R. 3306, introduced by ...
(Date:7/30/2014)... Detroit, MI (PRWEB) July 30, 2014 ... community to celebrate Safety Day from 4 p.m. to ... in Livonia (29580 7 Mile Road, Livonia, MI 48152). ... DeKeyser, free bike helmets, children’s activities, music, snacks and ... for $299,497 to the Children’s Hospital of Michigan Foundation. ...
(Date:7/30/2014)... Hospitals continually face the challenge of ... their practitioners provide. During a recent AllMed webinar, ... importance of establishing effective peer review practitioner evaluation ... of care. , With regard to best ... on setting performance expectations, conducting regular evaluations, maintaining ...
Breaking Medicine News(10 mins):Health News:LTC Consumer Launches Online Tool for Getting Instant Long Term Care Insurance Estimates 2Health News:Power Morcellator Controversy Grows, as Bernstein Liebhard LLP Notes Another Call to Ban Uterine Morcellation 2Health News:Power Morcellator Controversy Grows, as Bernstein Liebhard LLP Notes Another Call to Ban Uterine Morcellation 3Health News:Power Morcellator Controversy Grows, as Bernstein Liebhard LLP Notes Another Call to Ban Uterine Morcellation 4Health News:ATA Applauds Senators’ Push for Federal Telemedicine Improvements 2Health News:Kohl’s, Children’s Hospital of Michigan Foundation Host Safety Day with Detroit Red Wings Defenseman Danny DeKeyser, Bike Helmets, Family Activities and More 2Health News:Kohl’s, Children’s Hospital of Michigan Foundation Host Safety Day with Detroit Red Wings Defenseman Danny DeKeyser, Bike Helmets, Family Activities and More 3Health News:Kohl’s, Children’s Hospital of Michigan Foundation Host Safety Day with Detroit Red Wings Defenseman Danny DeKeyser, Bike Helmets, Family Activities and More 4Health News:AllMed Webinar Helps Hospitals Optimize Practitioner Evaluations in Peer Review 2Health News:AllMed Webinar Helps Hospitals Optimize Practitioner Evaluations in Peer Review 3
(Date:7/30/2014)... SCHOFIELD, Wis. , July 30, 2014 /PRNewswire/ ... researcher, developer, and marketer of over-the-counter (OTC) medicinal ... is rebranding the LipiGesic ® M name along with ... will be replaced with the trademarked name MigraPure ... and color palette of PuraMed,s homeopathic, natural migraine ...
(Date:7/30/2014)... , July 30, 2014 Research and Markets ... Reagents Market - Forecasts to 2019" report to their offering. ... market is estimated to grow at a lower CAGR in developed ... countries such as China , India ... five years. The growth of the hematology analyzers and ...
(Date:7/30/2014)... 30, 2014  Today the US Surgeon General issued the ... tanning or sun burns stating they can lead directly to ... Boris Lushniak , says that "skin cancer is a major ... much exposure to indoor and outdoor ultraviolet light is a ... Medicine, in Boca Raton, Florida , ...
Breaking Medicine Technology:PuraMed BioScience Rebrands its Natural Migraine Relief Medication, LipiGesic M 2PuraMed BioScience Rebrands its Natural Migraine Relief Medication, LipiGesic M 3Hematology Analyzers & Reagents Market - Forecasts to 2019 2Indoor and Outdoor Sun Tanning or Sun Burns Directly Linked to Deadly Melanoma Skin Cancer 2
Cached News: