HOME >> MEDICINE >> NEWS
Discovery Hints At Multitude Of New Targets For Drugs

tion, of the receptor. Previously, most scientists believed that this conformational change could only produce an on-off response.

Some of the new findings supported that early view. The researchers found that some of the test compounds were "agonists" of the receptor, switching it on. And others were "antagonists," blocking its action.

However, surprisingly, they discovered a new class of compounds that behaved differently from either of the first two classes. The compounds functioned as agonists in some cellular contexts, but as antagonists in others.

Discovery of this third class has broad clinical implications, said Donald McDonnell, an associate professor of pharmacology in the Duke medical center. The finding extends earlier work in his laboratory showing that the estrogen receptor, a distinctly different kind of steroid receptor, also shows similar mulitple modes of interaction with drugs or hormones.

"The discovery of such complexity in one receptor type is a phenomenon; the discovery of two is a paradigm," said McDonnell. "It's likely that these findings will extend to other receptors, such as the male androgen receptor," he said.

According to McDonnell, the discovery of new ways to affect such receptors could produce significant changes in the strategies by which pharmacologists seek new drugs to modulate them.

"To target drugs to one body tissue, pharmacologists have traditionally looked for subtypes of a receptor unique to that tissue," he said. "They could then design compounds that would select one or another subtype. But if there was only one kind of receptor, they were stuck.

"But now, our laboratory and others are showing that different compounds acting through the same receptor can manifest different biologies in different cells. We believe this extremely exciting realization will bring the next wave in the understanding of hormone a
'"/>

Contact: Karyn George
georg016@mc.duke.edu
919-660-1301
Duke University
20-Aug-1996


Page: 1 2 3 4

Related medicine news :

1. Discovery of pathway in learning impairment caused by liver disease may lead to drug treatment
2. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
3. Discovery of the oldest remains of a woman who died in childbirth
4. Discovery sheds light on how cancer cells grow and divide
5. Discovery changes ideas about damage from strokes
6. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003
7. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003
8. GlaxoSmithKline Drug Discovery and Development Award 2002
9. Discovery may lead to new HIV drugs, says Jefferson virologist
10. GlaxoSmithKline Drug Discovery and Development Award 2002
11. "Radical" Discovery Advances Medicine and Plastics

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now ... of Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. ... Final Cut Pro X users can now reveal the media of their split ...
(Date:6/27/2016)... ... 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to Best Buy ... in the United States and Canada wear eyeglasses. Once considered to be a purely ... make a fashion statement. Even celebrities use glasses as a way of creating an ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned by ... to enhance the health of felines. The formula is all-natural and is made from ... the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery ... of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , ... for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey ...
(Date:6/25/2016)... CA (PRWEB) , ... June 25, 2016 , ... As ... with Magna Cum Laude and his M.D from the David Geffen School of Medicine ... and returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... OAKLAND, N.J. , June 24, 2016 /PRNewswire/ ... in the design, development and manufacturing of collagen ... and regeneration announced today that Bill Messer ... Sales and Marketing to further leverage the growing ... surgery medical devices. Bill joins the ...
(Date:6/24/2016)... Dublin ... of the " Global Markets for Spectroscopy Equipment" ... This report focuses on the global ... including its applications in various applications. The report deals ... three main industries: pharmaceutical and biotechnology, food and beverage, ...
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical ... the "Company"), which develops, markets and sells medical devices ... , signed a strategic cooperation agreement with Hongyuan ... "Hongyuan Supply Chain") on June 20, 2016, to develop ... the strategic cooperation agreement, Dehaier will leverage Hongyuan Supply ...
Breaking Medicine Technology:
Cached News: