HOME >> MEDICINE >> NEWS
Discovery Hints At Multitude Of New Targets For Drugs

tion, of the receptor. Previously, most scientists believed that this conformational change could only produce an on-off response.

Some of the new findings supported that early view. The researchers found that some of the test compounds were "agonists" of the receptor, switching it on. And others were "antagonists," blocking its action.

However, surprisingly, they discovered a new class of compounds that behaved differently from either of the first two classes. The compounds functioned as agonists in some cellular contexts, but as antagonists in others.

Discovery of this third class has broad clinical implications, said Donald McDonnell, an associate professor of pharmacology in the Duke medical center. The finding extends earlier work in his laboratory showing that the estrogen receptor, a distinctly different kind of steroid receptor, also shows similar mulitple modes of interaction with drugs or hormones.

"The discovery of such complexity in one receptor type is a phenomenon; the discovery of two is a paradigm," said McDonnell. "It's likely that these findings will extend to other receptors, such as the male androgen receptor," he said.

According to McDonnell, the discovery of new ways to affect such receptors could produce significant changes in the strategies by which pharmacologists seek new drugs to modulate them.

"To target drugs to one body tissue, pharmacologists have traditionally looked for subtypes of a receptor unique to that tissue," he said. "They could then design compounds that would select one or another subtype. But if there was only one kind of receptor, they were stuck.

"But now, our laboratory and others are showing that different compounds acting through the same receptor can manifest different biologies in different cells. We believe this extremely exciting realization will bring the next wave in the understanding of hormone a
'"/>

Contact: Karyn George
georg016@mc.duke.edu
919-660-1301
Duke University
20-Aug-1996


Page: 1 2 3 4

Related medicine news :

1. Discovery of pathway in learning impairment caused by liver disease may lead to drug treatment
2. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
3. Discovery of the oldest remains of a woman who died in childbirth
4. Discovery sheds light on how cancer cells grow and divide
5. Discovery changes ideas about damage from strokes
6. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003
7. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003
8. GlaxoSmithKline Drug Discovery and Development Award 2002
9. Discovery may lead to new HIV drugs, says Jefferson virologist
10. GlaxoSmithKline Drug Discovery and Development Award 2002
11. "Radical" Discovery Advances Medicine and Plastics

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Discovery Hints Multitude New Targets For Drugs

(Date:4/21/2015)... 21, 2015 Carinsuranceshoppingsource.com has released ... comprehensive auto insurance plans . , Comprehensive ... coverage for numerous situations. The coverage limit can also ... auto insurance will protect a car against fire damage, ... Comparing quotes is no longer difficult and it can ...
(Date:4/21/2015)... 2015 As a provider of holistic, ... that their rehabilitation strategy, which involves various treatment modalities, ... In an effort to offer hope and encouragement to ... lives, Best Drug Rehabilitation has featured a series of ... successful graduates of their recovery program. , One ...
(Date:4/21/2015)... April 21, 2015 – Vancouver, BC – ... http://www.idataresearch.com ), growth within the U.S. spinal implant market ... in existing technologies. The most notable development in spinal ... Many companies are developing new minimally invasive products to ... more traditional spinal fixation products. , Some spinal ...
(Date:4/21/2015)... Le Petit Retreat Day Spa in L.A. is ... the leafy, historic Larchmont neighborhood, newly renamed as the Larchmont ... of “Disconnect to Reconnect.” Tina Figueroa, a former tech ... spa, announces the new name and new vision for the ... help celebrate connections with Moms and their adult children. ...
(Date:4/21/2015)... Carinsuranceshoppingsource.com has released a new blog ... for ecological vehicles. , Eco-friendly cars can ... safer driving experience. Some insurance agencies may even offer ... a new vehicle, clients should consider the costs of ... car will always cost more to insure. Eco-friendly vehicles ...
Breaking Medicine News(10 mins):Health News:Comprehensive Auto Insurance Is An Important But Complex Policy 2Health News:Best Drug Rehabilitation Graduate Discusses Making Amends and Rebuilding Relationships 2Health News:Increasing Competition Driven by Technological Shifts in U.S. Spinal Implant Market; DePuy Synthes Continues to Challenge Medtronic’s Lead 2Health News:Increasing Competition Driven by Technological Shifts in U.S. Spinal Implant Market; DePuy Synthes Continues to Challenge Medtronic’s Lead 3Health News:Larchmont Sanctuary Spa Revealed as New Name For Neighborhood Spa; New Owner, New Eco Offerings & New Theme: “Disconnect to Reconnect” 2Health News:Larchmont Sanctuary Spa Revealed as New Name For Neighborhood Spa; New Owner, New Eco Offerings & New Theme: “Disconnect to Reconnect” 3Health News:Auto Insurance Quotes For Eco-Friendly Vehicles 2
(Date:4/21/2015)... , April 21, 2015  Decision Diagnostics Corp. ... and the exclusive worldwide sales, service and regulatory ... FDA-cleared Green Alternative Strip, specifically designed to work ... OneTouch Ultra family of glucose testing meters, the ... today that Johnson & Johnson/Lifescan has requested an ...
(Date:4/21/2015)... 2015  Navitas has launched Aviator, a Cloud Based ... offerings for life sciences clients. Aviator supports Regulatory, Clinical ... seamless flow of data across all applications and into ... worked closely with Oracle to provide Argus, Life Sciences ... the Cloud. ...
(Date:4/21/2015)...  TissueGene, Inc. a clinical-stage biopharmaceutical company focused ... of cell therapy, today announced the appointment of ... Operating Officer.  Mr. Newman was most recently Senior ... at ZIOPHARM Oncology, a Boston, Massachusetts ... control and cell technologies in the cancer treatment ...
Breaking Medicine Technology:Decision Diagnostics Shrugs Off New Attack As Johnson & Johnson Panics In Patent Case 2Decision Diagnostics Shrugs Off New Attack As Johnson & Johnson Panics In Patent Case 3Navitas Launches Aviator - Cloud Based Platforms for Oracle Solutions 2Navitas Launches Aviator - Cloud Based Platforms for Oracle Solutions 3Navitas Launches Aviator - Cloud Based Platforms for Oracle Solutions 4TissueGene, Inc. Hires Robert Newman as Chief Operating Officer 2
Cached News: