HOME >> MEDICINE >> NEWS
Discovery May Boost Effectiveness Of Chemotherapy

Researchers at the University of Maryland Greenebaum Cancer Center have made a discovery that may explain why some cases of breast cancer and other forms of cancer are resistant to chemotherapy. Their findings, published in the December 22, 1998, issue of Proceedings of the National Academy of Sciences, may lead to better ways to target chemotherapy to individual patients and may open the door to new strategies to reverse resistance to cancer-fighting drugs.

"We have found a cancer resistance protein that rapidly pumps out chemotherapy from a certain line of breast cancer cells," says L. Austin Doyle, M.D., associate professor of medicine at the University of Maryland School of Medicine who is the lead author of the article.

The researchers call the newly-discovered pump Breast Cancer Resistance Protein (BCRP). They found that this protein pumped three common anti-cancer drugs out of cells rapidly, before the drugs could get to the nucleus of the cancer cells and destroy them.

"This is only the fourth molecular drug resistance pump of anti-cancer drugs to be identified, and it is half the size of the other pumps," says Douglas D. Ross, M.D., Ph.D, professor of medicine at the University of Maryland School of Medicine. "We had been looking for years for a way to explain resistance among this group of resistant cancer cells, so this is an important step," adds Dr. Ross, who is a co-author of the article.

The researchers, along with Lynne Abrusso, M.D., Ph.D, assistant professor of pathology at the University of Maryland School of Medicine, studied resistant and non-resistant cancer cells to find genes that were different among the two groups. They used molecular biology techniques to isolate the unique BCRP gene from drug-resistant cancer cells. Then, they tested their theory by changing non-resistant cells into resistant ones by inserting the BCRP gene into them.

"Drug resistance is a big
'"/>

Contact: Ellen Beth Levitt
eblevitt@umms001.ab.umd.edu
410-328-8919
University of Maryland Medical Center
21-Dec-1998


Page: 1 2

Related medicine news :

1. Discovery of pathway in learning impairment caused by liver disease may lead to drug treatment
2. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
3. Discovery of the oldest remains of a woman who died in childbirth
4. Discovery sheds light on how cancer cells grow and divide
5. Discovery changes ideas about damage from strokes
6. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003
7. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003
8. GlaxoSmithKline Drug Discovery and Development Award 2002
9. Discovery may lead to new HIV drugs, says Jefferson virologist
10. GlaxoSmithKline Drug Discovery and Development Award 2002
11. "Radical" Discovery Advances Medicine and Plastics

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... ProVest Insurance Group, a family ... and Raleigh regions, is organizing an extended charity drive to benefit the family ... abnormality. , After struggling since birth with several health challenges, T.J. was later ...
(Date:10/13/2017)... ... October 13, 2017 , ... As health professionals work ... as “patient engagement.” The patient is doing more than filling out a survey; in ... “There is an increasing emphasis in health care and research on the importance of ...
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of Family Medicine's ... President and Chief Executive Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. ... 2018 until Dr. Puffer’s retirement at the end of 2018. Upon assuming the role ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... PurhealthRX ... CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil will ... and providing a CBD form that can be easily incorporated into liquid products, while ...
(Date:10/13/2017)... ... 13, 2017 , ... Lori R. Somekh, founder of the Law Office ... of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our office ... forum to network with elder law attorneys nationwide,” said Somekh. , ElderCounsel ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... 27, 2017  Commended for their devotion to personalized service, ... as number one in the South Florida Business Journal,s 50 ... 5000 yearly list, the national specialty pharmacy has found its ... will soon be honored by SFBJ as the 2017 ... Set to receive his award in October, Bardisa said ...
(Date:9/22/2017)... Md. , Sept. 22, 2017  As the ... Republican Senators Bill Cassidy (R-LA) and ... Information notes that the medical device industry is in ... medical device tax, the 2.3% excise tax on medical ... But they also want covered patients, increased visits and ...
(Date:9/18/2017)... 2017 EpiVax, Inc. ("EpiVax") a ... immune engineering, today announced a new NIH-funded ... ... and presents a challenge for traditional flu ... be effective. Using state-of-the-art bioinformatics and molecular modeling methods, ...
Breaking Medicine Technology:
Cached News: