HOME >> MEDICINE >> NEWS
Discovery changes ideas about damage from strokes

In experiments in the laboratory and with mice, the Johns Hopkins researchers found that the chemical prostaglandin-E2 protects brain cells from damage. The finding was completely unexpected, the researchers say, because prostaglandin-E2 causes damage in other tissues and is made by an enzyme, COX-2, known to wreak havoc in the brain after injury. The findings appear in the Jan. 7 issue of the Journal of Neuroscience.

"It's kind of paradoxical, that the product of an enzyme that causes damage is itself beneficial," says Katrin Andreasson, M.D., an assistant professor of neurology and of neuroscience. "It's possible that future treatments for stroke might use drugs to block COX-2 and enhance the effects of prostaglandin-E2, providing sort of a double whammy of protection.

"Prostaglandins have not previously been implicated in reducing damage from stroke, so our finding provides a completely new strategy for tackling and understanding the condition," she adds.

In experiments with individual brain cells and with brain slices from mice, the researchers discovered that prostaglandin-E2 (PGE2), one of many related molecules created by COX-2, protects brain cells traumatized by over-stimulation or by insufficient oxygen. Furthermore, in genetically engineered mice lacking one of the receptors, or docking points, for this prostaglandin, stroke damage was much greater than in normal mice, the researchers report.

"Together, these results provide very strong evidence that PGE-2 is indeed protective in the brain even though it may not be elsewhere in the body," says Andreasson, who obtained the genetically engineered mice from Richard Breyer at Vanderbilt University School of Medicine.

After their surprising discovery, the research team searched for why PGE2 is a "good guy" in the brain. Their experiments showed that stimulation of PGE2's receptor increases production of a molecule called cyclic-AMP, which is known to he
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
12-Jan-2004


Page: 1 2 3

Related medicine news :

1. Discovery of pathway in learning impairment caused by liver disease may lead to drug treatment
2. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
3. Discovery of the oldest remains of a woman who died in childbirth
4. Discovery sheds light on how cancer cells grow and divide
5. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003
6. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003
7. GlaxoSmithKline Drug Discovery and Development Award 2002
8. Discovery may lead to new HIV drugs, says Jefferson virologist
9. GlaxoSmithKline Drug Discovery and Development Award 2002
10. "Radical" Discovery Advances Medicine and Plastics
11. Vanderbilt Cancer Center Discovery May Help Overcome Resistance To Anti-Breast Cancer Drug

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Discovery changes ideas about damage from strokes

(Date:4/28/2015)... 2015 Foot and Ankle Specialists ... D. Palmer ( Annapolis and Clarksville Divisions ) ... at the Maryland Podiatric Medical Association meeting on April ... University in 1992 with a Bachelor of Arts in ... in intercollegiate soccer, track and cross-country. He then attended ...
(Date:4/27/2015)... 2015 Churchview Supportive Living, a Gardant ... Brunch and Fashion Show from 10:30 a.m. to noon ... at 2626 W. 63rd St. in Chicago, serves low-income ... help to maintain their independence. , “Mothers, grandmothers, godmothers ... Mother’s Day Brunch,” said Director of Marketing Elizabeth Clippard. ...
(Date:4/27/2015)... 28, 2015 Healthcare marketing specialists ... called “Website Anatomy 101.” Available for ... necessary design elements for a successful hospital website. ... design, user experience, search results and lead generation ... a well-designed website on patient volume and retention. ...
(Date:4/27/2015)... Tennessee (PRWEB) April 27, 2015 A variety ... help young people trapped in substance abuse. Programming for Jericho ... will serve girls, is launching this summer. , The first ... than $100,000 to serve adolescents. The Youth Town Jim Jackson ... Collierville on Monday, May 4, with tee times at 8 ...
(Date:4/27/2015)... 2015 "Understanding Mental Disorders: Your Guide ... by American Psychiatric Publishing, a division of the American ... at the National Press Club in Washington, D.C.. The ... by APA President Paul Summergrad, MD. Guest speakers will ... foreword to the book; Paul Gionfriddo, President and CEO ...
Breaking Medicine News(10 mins):Health News:Foot and Ankle Specialists of the Mid-Atlantic, LLC Podiatrist Receives Maryland Podiatric Medical Association Outstanding Service Award 2Health News:Churchview Supportive Living Community in Chicago to Host Mother's Day Brunch 2Health News:Smith & Jones Publishes 2015 Website Design White Paper 2Health News:Golf, Sermon on the Mount and More to Support Youth Town’s Jericho and Eden Programs 2Health News:American Psychiatric Association, Patrick Kennedy To Debut New Consumer Guidebook “Understanding Mental Disorders” 2
(Date:4/27/2015)... , April 27, 2015 Harwood Feffer LLP ... board of directors of Aerie Pharmaceuticals, Inc. ("Aerie" or ... board has breached its fiduciary duties to shareholders. ... press release announcing results from its first Phase 3 ... release disclosed that in the trial, Rhopressa failed to ...
(Date:4/27/2015)... Bronstein, Gewirtz & Grossman, LLC is investigating ... of Celladon Corporation ("Celladon" or the "Company") (NasdaqGM: CLDN ... Bronstein or his investor relations coordinator Eitan ... The investigation concerns whether Celladon and certain of ... 20(a) of the Securities Exchange Act of 1934.  ...
(Date:4/27/2015)... 2015  Eiger BioPharmaceuticals, Incorporated today announced the presentation ... in patients with chronic hepatitis delta viral (HDV) infection. ... at Ankara University Medical School, Turkey ... LOWR HDV - 1 (LOnafarnib With and ... randomized subjects to receive different doses of lonafarnib with ...
Breaking Medicine Technology:Harwood Feffer LLP Announces Investigation of Aerie Pharmaceuticals, Inc. 2SHAREHOLDER ALERT: Bronstein, Gewirtz & Grossman, LLC Announces Investigation of Celladon Corporation 2Eiger Bio Announces Interim Results of Lonafarnib in Combination with Ritonavir or Pegylated Interferon in Patients Infected with Hepatitis Delta Virus (HDV) 2Eiger Bio Announces Interim Results of Lonafarnib in Combination with Ritonavir or Pegylated Interferon in Patients Infected with Hepatitis Delta Virus (HDV) 3
Cached News: