HOME >> MEDICINE >> NEWS
Discovery changes ideas about damage from strokes

In experiments in the laboratory and with mice, the Johns Hopkins researchers found that the chemical prostaglandin-E2 protects brain cells from damage. The finding was completely unexpected, the researchers say, because prostaglandin-E2 causes damage in other tissues and is made by an enzyme, COX-2, known to wreak havoc in the brain after injury. The findings appear in the Jan. 7 issue of the Journal of Neuroscience.

"It's kind of paradoxical, that the product of an enzyme that causes damage is itself beneficial," says Katrin Andreasson, M.D., an assistant professor of neurology and of neuroscience. "It's possible that future treatments for stroke might use drugs to block COX-2 and enhance the effects of prostaglandin-E2, providing sort of a double whammy of protection.

"Prostaglandins have not previously been implicated in reducing damage from stroke, so our finding provides a completely new strategy for tackling and understanding the condition," she adds.

In experiments with individual brain cells and with brain slices from mice, the researchers discovered that prostaglandin-E2 (PGE2), one of many related molecules created by COX-2, protects brain cells traumatized by over-stimulation or by insufficient oxygen. Furthermore, in genetically engineered mice lacking one of the receptors, or docking points, for this prostaglandin, stroke damage was much greater than in normal mice, the researchers report.

"Together, these results provide very strong evidence that PGE-2 is indeed protective in the brain even though it may not be elsewhere in the body," says Andreasson, who obtained the genetically engineered mice from Richard Breyer at Vanderbilt University School of Medicine.

After their surprising discovery, the research team searched for why PGE2 is a "good guy" in the brain. Their experiments showed that stimulation of PGE2's receptor increases production of a molecule called cyclic-AMP, which is known to he
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
12-Jan-2004


Page: 1 2 3

Related medicine news :

1. Discovery of pathway in learning impairment caused by liver disease may lead to drug treatment
2. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
3. Discovery of the oldest remains of a woman who died in childbirth
4. Discovery sheds light on how cancer cells grow and divide
5. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003
6. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003
7. GlaxoSmithKline Drug Discovery and Development Award 2002
8. Discovery may lead to new HIV drugs, says Jefferson virologist
9. GlaxoSmithKline Drug Discovery and Development Award 2002
10. "Radical" Discovery Advances Medicine and Plastics
11. Vanderbilt Cancer Center Discovery May Help Overcome Resistance To Anti-Breast Cancer Drug

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... Aliso Viejo, California (PRWEB) , ... June 26, 2016 , ... ... for Final Cut Pro X. , "Film editors can give their videos a whole ... artistically," said Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels ...
(Date:6/25/2016)... ... 2016 , ... Experts from the American Institutes for Research ... June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR experts ... planning, healthcare costs and patient and family engagement. , AIR researchers will be ...
(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of ... of the latter, setting the bar too high can result in disappointment, perhaps even ... progress toward their goal. , Research from PsychTests.com reveals that behind ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Research and Markets has announced the addition ... to their offering. The ... commercial environment for MedImmune to enter. The US ageing population ... to drive considerable growth for effective anti-influenza medications. The introduction ... considerably, but development is still in its infancy. ...
(Date:6/23/2016)... , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with ... Latin America . ... ... ... ...
(Date:6/23/2016)... -- Research and Markets has announced the ... (United States, China, Japan, Brazil, United Kingdom, Germany, France, ... Surgical Procedure Volumes: ... provides surgical procedure volume data in a geographic context. ... analysis of growth drivers and inhibitors, including world population ...
Breaking Medicine Technology:
Cached News: