HOME >> MEDICINE >> NEWS
Discovery of pathway in learning impairment caused by liver disease may lead to drug treatment

Liver disease sometimes causes hepatic encephalopathy, which involves brain damage, personality changes, and intellectual impairment due to hyperammonemia (high levels of ammonia in the blood). However, the mechanisms involved in both learning and how liver disease leads to learning impairment are unclear.

In a new study led by Vicente Felipo of the Laboratory of Neurobiology at the Fundacion Valenciana de Investigaciones Biomedicas in Valencia, Spain and published in the February 2005 issue of Hepatology, researchers hypothesized that impaired learning was due to a defect in the glutamate-nitric oxide-cGMP pathway in the brain and that administering sildenafil to increase cGMP would restore learning ability. Sildenafil, commonly known as Viagra, is known to prevent the destruction of cGMP and allow it to accumulate in the body. Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD), published by John Wiley & Sons, Inc. is available online via Wiley InterScience at http://www.interscience.wiley.com/journal/hepatology.

Researchers examined four groups of rats in their study: rats in which they constructed portacaval shunts (a treatment used to treat high blood pressure in the liver due to liver disease that is believed to be one of the causes of hepatic encephalopathy, and also a model of chronic liver failure in rats); rats with portacaval shunts that were given sildenafil; rats that were fed an ammonium-containing diet; and rats that were fed the diet and given sildenafil. They also used control groups consisting of rats fed a normal diet both with and without sildenafil. All animals were subjected to a maze learning test four weeks following surgery or from the date when drug treatment began. Levels of both cGMP and ammonia in brain were measured using a microdialysis probe.

Results showed that while rats with the portacaval
'"/>

Contact: David Greenberg
dgreenbe@wiley.com
201-748-6484
John Wiley & Sons, Inc.
19-Jan-2005


Page: 1 2

Related medicine news :

1. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
2. Discovery of the oldest remains of a woman who died in childbirth
3. Discovery sheds light on how cancer cells grow and divide
4. Discovery changes ideas about damage from strokes
5. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003
6. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003
7. GlaxoSmithKline Drug Discovery and Development Award 2002
8. Discovery may lead to new HIV drugs, says Jefferson virologist
9. GlaxoSmithKline Drug Discovery and Development Award 2002
10. "Radical" Discovery Advances Medicine and Plastics
11. Vanderbilt Cancer Center Discovery May Help Overcome Resistance To Anti-Breast Cancer Drug

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/15/2018)... ... November 15, 2018 , ... Mothers and babies across ... unique collaboration that puts vital health education resources right at their fingertips. The ... Promise Health Plan effective 1/1/19), an affiliate of Blue Shield of California, and ...
(Date:11/15/2018)... , ... November 15, 2018 , ... The National Cancer ... While advancing age is the primary risk factor for cancer and we typically associate ... under the age of 45. And with aggressive treatment and advanced therapies, increasing numbers ...
(Date:11/15/2018)... ... November 15, 2018 , ... Access today announced ... web-based eForms solution for hospitals . This release features tight integration with Epic, ... from any of these systems, have patients electronically sign them on tablets, and ...
(Date:11/15/2018)... ... 2018 , ... Associated Urologists of Nashville today announced that ... designation recognizes that Dr. Dehner has achieved a high level of training and ... men suffering from symptoms associated with Benign Prostatic Hyperplasia or BPH. , ...
(Date:11/15/2018)... Fla. (PRWEB) , ... November 15, 2018 , ... ... and clinical educator for Specialty MED Training will take the stage during ... happening December 13-15, 2019. Dr. Vuich is leading a CME workshop hosted by ...
Breaking Medicine News(10 mins):
(Date:11/16/2018)... ... November 16, 2018 , ... , ChiroTrust, Chiropractic’s first and only group ... their neck and back pain, is attracting patients back to Chiropractic. , “The Pledge ... they need more patients, they have a bigger problem that more new patients won’t ...
(Date:11/16/2018)... ... 16, 2018 , ... All Natural Way, a leader in ... of its newly redesigned website. , The new website’s easy-to-navigate interface aims ... newly redesigned website will be regularly updated with news of product launches, company ...
(Date:11/16/2018)... ... November 16, 2018 , ... OnlineMasters.com, a ... release of the Best Online Master's in Marriage And Family Counseling Programs in ... affordability, and graduate outcomes. , The research organization analyzed graduate schools across the ...
Breaking Medicine Technology:
Cached News: