Disoriented T cells cause liver disease

T cells activated in the gut during inflammatory bowel disease can be re-routed to the liver and cause chronic liver disease, according to Eksteen and colleagues in the December 1 issue of The Journal of Experimental Medicine.

A chronic liver disease known as primary sclerosing cholangitis (PSC) has been linked to inflammatory bowel disease (IBD) in the past. But the connection between the two disorders has been unclear, especially as the liver condition often develops years after IBD has resolved or the colon has been surgically removed. Eksteen and colleagues now show that T cells that were activated in the gut probably during IBD - are found in the livers of patients with PSC, but not in those of patients with other inflammatory liver diseases.

The authors explain this detour by showing that an attractant protein that normally directs T cells into the gut is aberrantly produced in the liver during PSC. T cells expressing the receptor for the protein are thus re-routed to the liver, although the authors do not know what triggers liver cells to make the attractant in the first place. T cells can survive as memory cells for many years after they are activated, and the authors believe this may explain how the liver disease can crop up years after IBD has resolved.


Contact: Nikki Henry
Journal of Experimental Medicine

Page: 1

Related medicine news :

1. Suppressing the cells that trigger cat allergy
2. Indiana University researchers closer to helping hearing-impaired using stem cells
3. Some brain cells change channels to fine-tune the message
4. Hopkins begins human trials with donor adult stem cells to repair muscle damaged from heart attack
5. Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression
6. Study suggests smoking while pregnant may increase chromosomal abnormalities in fetal cells
7. Computational tool predicts how drugs work in cells, advancing efforts to design better medicines
8. Smart immune cells kill more cancer
9. CK2 protein sustains colon cancer cells by sabotaging ability to commit suicide
10. Protein that promotes survival of stem cells might be key to poor leukemia prognosis
11. PCBs, fungicide open brain cells to Parkinsons assault

Post Your Comments:

(Date:11/24/2015)... ... 2015 , ... Preparing for the LDT Regulation:, CLIA Won’t Satisfy the FDA, ... , FDA has long asserted that design and manufacture of Laboratory Developed Tests (LDTs) ... not meet the device regulations. , Come up short in an inspection and the ...
(Date:11/24/2015)... Richey, FL (PRWEB) , ... November 24, 2015 , ... ... deems a growing epidemic as deaths from prescription opioids in the United States grew ... and cocaine. In 2013 alone, opioids were involved in 37 percent of all fatal ...
(Date:11/24/2015)... ... November 24, 2015 , ... American Family Care (AFC), the ... of a holiday pop-up clinic located in Metro Atlanta’s North Point Mall. The clinic ... and different way. The location is scheduled to operate through Dec. 24. , Holiday ...
(Date:11/24/2015)... CA (PRWEB) , ... November 24, 2015 , ... Cold Shoulder , LLC launched ... Kickstarter last week and hit their goal of $20,000 in under 10 hours. ... aims to bring the new PRO Weight Loss Vest to the market. , The PRO ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... its exceptional customer service: the TrustDale certification. The award recognizes good companies for ... stone honing , tile and grout, and hard surface restoration company earned this ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... , November 24, 2015 F1000Workspace ... scientists - since it was launched just six months ago. ... management and authoring platform for scientists - since it was ... references have been loaded on to F1000Workspace - ... - since it was launched just six months ago. ...
(Date:11/24/2015)... , Nov. 24, 2015 iRhythm Technologies, Inc. , ... care, today announced that it will participate in the 27th Annual ... New York, NY . Kevin King ... Tuesday December 1, 2015 at 8:50am ET. ... www.irhythmtech.com . --> www.irhythmtech.com . --> ...
(Date:11/24/2015)... The uptake of recently approved and pipeline premium products for Type 1 ... 2021, says GBI Research . --> ... Diabetes Mellitus (T1DM), will be a key driver of market growth to ... The uptake of recently approved and pipeline premium products for Type ... to 2021, says GBI Research . ...
Breaking Medicine Technology:
Cached News: