HOME >> MEDICINE >> NEWS
Disoriented T cells cause liver disease

T cells activated in the gut during inflammatory bowel disease can be re-routed to the liver and cause chronic liver disease, according to Eksteen and colleagues in the December 1 issue of The Journal of Experimental Medicine.

A chronic liver disease known as primary sclerosing cholangitis (PSC) has been linked to inflammatory bowel disease (IBD) in the past. But the connection between the two disorders has been unclear, especially as the liver condition often develops years after IBD has resolved or the colon has been surgically removed. Eksteen and colleagues now show that T cells that were activated in the gut probably during IBD - are found in the livers of patients with PSC, but not in those of patients with other inflammatory liver diseases.

The authors explain this detour by showing that an attractant protein that normally directs T cells into the gut is aberrantly produced in the liver during PSC. T cells expressing the receptor for the protein are thus re-routed to the liver, although the authors do not know what triggers liver cells to make the attractant in the first place. T cells can survive as memory cells for many years after they are activated, and the authors believe this may explain how the liver disease can crop up years after IBD has resolved.


'"/>

Contact: Nikki Henry
henryn@rockefeller.edu
212-327-8366
Journal of Experimental Medicine
29-Nov-2004


Page: 1

Related medicine news :

1. Suppressing the cells that trigger cat allergy
2. Indiana University researchers closer to helping hearing-impaired using stem cells
3. Some brain cells change channels to fine-tune the message
4. Hopkins begins human trials with donor adult stem cells to repair muscle damaged from heart attack
5. Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression
6. Study suggests smoking while pregnant may increase chromosomal abnormalities in fetal cells
7. Computational tool predicts how drugs work in cells, advancing efforts to design better medicines
8. Smart immune cells kill more cancer
9. CK2 protein sustains colon cancer cells by sabotaging ability to commit suicide
10. Protein that promotes survival of stem cells might be key to poor leukemia prognosis
11. PCBs, fungicide open brain cells to Parkinsons assault

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... ... ... The American College of Medical Informatics (ACMI) will present the 2017 Morris F. ... AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is taking place ... the field of medical informatics, this prestigious award is presented to an individual whose ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa Mohebi, ... a medical article to the newly revamped Cosmetic Town journal section, ... hair transplant procedure known as Follicular Unit Extraction (FUE). , Dr. ...
(Date:10/12/2017)... FL (PRWEB) , ... October 12, 2017 , ... On ... holding a treadmill relay – Miles by Moonlight to raise money for the American ... $300 or more. , Teams will work together to keep their treadmills moving ...
(Date:10/12/2017)... ... 12, 2017 , ... In the United States, single-family home ... states—like New York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and California—the average is ... low property-tax rates, which contributes to the relatively lower cost of living in ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... Pepper Flow promotional review platform at the Promotional Review Committee Compliance and ... help marketers streamline the medical, legal, and regulatory review (MLR) process – ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... 2017  Commended for their devotion to personalized service, SMP ... number one in the South Florida Business Journal,s 50 Fastest-Growing ... yearly list, the national specialty pharmacy has found its niche.  ... will soon be honored by SFBJ as the 2017 Power ... Set to receive his award in October, Bardisa said of ...
(Date:9/25/2017)...  EpiVax, Inc., a leader in the fields ... announced the launch of EpiVax Oncology Inc., a ... cancer vaccines. EpiVax has provided $500,000 in seed ... technologies to the new precision immunotherapy venture. Gad ... as Chief Executive Officer. Gad brings over 25 ...
(Date:9/22/2017)... 22, 2017 AVACEN Medical (AVACEN) announced that ... successfully helping those with the widespread pain associated with ... Amanda in Essex, England commented, ... hair, experiencing no sleep at all, tremendous pain, with ... cannot recommend [the AVACEN 100] enough, how this has ...
Breaking Medicine Technology:
Cached News: