HOME >> MEDICINE >> NEWS
Disulfiram and cognitive behavioral therapy appear effective for treating cocaine dependence

CHICAGO Disulfiram (a drug used to help selected patients with alcohol disorders remain sober) and cognitive behavioral therapy appear effective in reducing cocaine use, especially among cocaine users who are not dependent on alcohol, according to an article in the March issue of The Archives of General Psychiatry, one of the JAMA/Archives journals.

Patients taking disulfiram who ingest even small amounts of alcohol develop a reaction that produces nausea, flushing, vomiting, and throbbing headache. At times, this reaction can be severe and can lead to critical illness, such as severe respiratory problems, circulatory problems, or even death. According to the article, alcohol is a powerful "cue" for using cocaine, and can impair judgment and lower resistance to cravings for cocaine. Researchers hypothesize that by reducing alcohol use with disulfiram, users might be less likely to abuse cocaine. However, use of disulfiram has not been evaluated in general populations of cocaine users.

Kathleen M. Carroll, Ph.D., from Yale University School of Medicine, New Haven, Conn., and colleagues randomly assigned 121 cocaine-dependent adults (average age, 34.6 years) to receive either disulfiram or placebo over a 12-week period. Participants were also randomized to participate in either cognitive behavioral therapy (CBT) or interpersonal psychotherapy (IPT, a less structured form of behavioral therapy).

"Participants assigned to disulfiram reduced their cocaine use significantly more than those assigned to placebo, and those assigned to CBT reduced their cocaine use significantly more than those assigned to IPT," the authors found. The benefits of disulfiram and CBT were most pronounced in participants who were not alcohol-dependent and who did not drink during the study.

The authors write, "This is the first placebo-controlled trial, to our knowledge, to demonstrate that disulfiram therapy is effective in nonalcoholic cocaine-dependent o
'"/>

Contact: Jacqueline Weaver
203-432-8555
JAMA and Archives Journals
1-Mar-2004


Page: 1 2

Related medicine news :

1. Boston University team finds link between high cholesterol and better cognitive performance
2. Binge drinking can impair both mood and cognitive performance
3. Nonhuman primate males more susceptible to age-related cognitive decline than females
4. Smoking causes cognitive impairment in adolescents
5. Maintaining physical activity linked to less cognitive decline in older men
6. Metabolic syndrome associated with cognitive decline in elderly persons
7. Study reveals link between cardiovascular risk and cognitive decline
8. Yale to study marijuana, ecstasy and teen cognitive deficits
9. Elderly experience long-term cognitive decline after surgery
10. High blood pressure related decline in cognitive function affects adults young and old
11. Trials launched to test treatment of cognitive dysfunction in schizophrenia

Post Your Comments:
(Date:11/28/2014)... Recently, SWAccessControl.com, a renowned smartware manufacturer, ... moment, all these high end products are offered at ... offer will last from today to Dec 16, 2014. ... to launch the promotion. We are proud of our ... the latest information about our hottest items, we have ...
(Date:11/28/2014)... Miami, FL (PRWEB) November 28, 2014 The ... With over 20,000 car accidents occurring in Florida every ... advise on the importance of auto insurance policies. , "Optional ... to drop. Auto insurance is not cheap I know, actually ... law the costs are even higher, but what I see ...
(Date:11/28/2014)... Boston, MA (PRWEB) November 28, 2014 Agein.com, ... news, and advice from some of the foremost experts in ... tips for preventing dry skin this winter. , “The official ... of North America has already been hit with an icy ... year, many are wondering if 2015 will usher in another ...
(Date:11/28/2014)... 2014 Now that the holiday season ... of the nation's leading cash-for-junk-cars companies, is improving their ... be more competitive and help bring a little bit ... time of year. , Along with purchasing expensive gifts ... US also deal with large travel expenses during the ...
(Date:11/28/2014)... Gables, Florida (PRWEB) November 28, 2014 ... Thanksgiving, Turbana and Sendik’s will present Feeding America Eastern ... with Sendik’s Food Market to donate a portion of ... participated in Sendik’s promotion, “7 Days, 7 Ways to ... throughout fall, Fyffes pineapples were two for $4 and ...
Breaking Medicine News(10 mins):Health News:New Access Control Systems Now Offered At Low Prices By Smartware Manufacturer SWAccessControl.com 2Health News:Car Accident Attorney Sean M. Cleary on Auto Insurance Policies Essential for Florida Drivers 2Health News:Agein Corporation, a Leading Anti-Aging Company, Releases Top Diet and Personal Care Tips for Preventing Dry Skin this Season 2Health News:Rusty's Auto Salvage Increasing Their Cash Offers to Help Drivers Save Throughout the Busy Holiday Season 2Health News:Turbana Partners With Sendik's Food Market to Donate $11,500 to Local Hunger-Relief Non-Profit 2Health News:Turbana Partners With Sendik's Food Market to Donate $11,500 to Local Hunger-Relief Non-Profit 3
(Date:11/28/2014)... QC , Nov. 28, 2014 /CNW Telbec/ - ... announce the appointment of Mrs. Dominique Boudreau ... its management team. Mrs. Dominique Boudreau was ... 2013 and occupied similar duties for more than seven ... Ergioresearch Ltd in January 2013.  Mrs. Boudreau replaces Mr. ...
(Date:11/28/2014)... , Nov. 28, 2014 Aratana Therapeutics, ... focused on the licensing or acquisition, development and commercialization ... companion animals, today announced that it will present at ... to be held December 2-3, 2014, at the New ... . Steven St. Peter , M.D., ...
(Date:11/28/2014)... -- Alimera Sciences, Inc. (NASDAQ: ALIM ... the research, development and commercialization of prescription ophthalmic ... with Deerfield Management and certain of its affiliates ... of preferred stock to Deerfield with an aggregate ... satisfaction of certain closing conditions. Alimera has also ...
Breaking Medicine Technology:Ergoresearch announces the appointment of its new Vice Président Finance 2Ergoresearch announces the appointment of its new Vice Président Finance 3Aratana Therapeutics to Present at the 26th Annual Piper Jaffray Healthcare Conference 2Alimera Sciences Announces Agreement with Deerfield Management for $50.0 Million Financing 2Alimera Sciences Announces Agreement with Deerfield Management for $50.0 Million Financing 3
Cached News: