HOME >> MEDICINE >> NEWS
Disulfiram and cognitive behavioral therapy appear effective for treating cocaine dependence

CHICAGO Disulfiram (a drug used to help selected patients with alcohol disorders remain sober) and cognitive behavioral therapy appear effective in reducing cocaine use, especially among cocaine users who are not dependent on alcohol, according to an article in the March issue of The Archives of General Psychiatry, one of the JAMA/Archives journals.

Patients taking disulfiram who ingest even small amounts of alcohol develop a reaction that produces nausea, flushing, vomiting, and throbbing headache. At times, this reaction can be severe and can lead to critical illness, such as severe respiratory problems, circulatory problems, or even death. According to the article, alcohol is a powerful "cue" for using cocaine, and can impair judgment and lower resistance to cravings for cocaine. Researchers hypothesize that by reducing alcohol use with disulfiram, users might be less likely to abuse cocaine. However, use of disulfiram has not been evaluated in general populations of cocaine users.

Kathleen M. Carroll, Ph.D., from Yale University School of Medicine, New Haven, Conn., and colleagues randomly assigned 121 cocaine-dependent adults (average age, 34.6 years) to receive either disulfiram or placebo over a 12-week period. Participants were also randomized to participate in either cognitive behavioral therapy (CBT) or interpersonal psychotherapy (IPT, a less structured form of behavioral therapy).

"Participants assigned to disulfiram reduced their cocaine use significantly more than those assigned to placebo, and those assigned to CBT reduced their cocaine use significantly more than those assigned to IPT," the authors found. The benefits of disulfiram and CBT were most pronounced in participants who were not alcohol-dependent and who did not drink during the study.

The authors write, "This is the first placebo-controlled trial, to our knowledge, to demonstrate that disulfiram therapy is effective in nonalcoholic cocaine-dependent o
'"/>

Contact: Jacqueline Weaver
203-432-8555
JAMA and Archives Journals
1-Mar-2004


Page: 1 2

Related medicine news :

1. Boston University team finds link between high cholesterol and better cognitive performance
2. Binge drinking can impair both mood and cognitive performance
3. Nonhuman primate males more susceptible to age-related cognitive decline than females
4. Smoking causes cognitive impairment in adolescents
5. Maintaining physical activity linked to less cognitive decline in older men
6. Metabolic syndrome associated with cognitive decline in elderly persons
7. Study reveals link between cardiovascular risk and cognitive decline
8. Yale to study marijuana, ecstasy and teen cognitive deficits
9. Elderly experience long-term cognitive decline after surgery
10. High blood pressure related decline in cognitive function affects adults young and old
11. Trials launched to test treatment of cognitive dysfunction in schizophrenia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/2/2016)... Las Vegas, NV (PRWEB) , ... May 02, ... ... with Specialty Pharmacy Times, has announced a new Specialty Pharmacy Patient Satisfaction Award ... be determined based on the quarterly results from Zitter Health Insights’ Specialty Pharmacy ...
(Date:5/2/2016)... ... 02, 2016 , ... The 2016 World Ultimate & Guts Championship (WUGC) Mixed roster was announced ... the cut. The WUGC is being held in London, England this year from June 18-25. ... men’s division, another gold in the women’s masters division, and a silver in the women’s ...
(Date:5/2/2016)... ... May 02, 2016 , ... Pregnancy Awareness Month offers a great time to ... , “If you are ready to have a baby, it’s best to get started ... Babies is your Personal Conception & Pregnancy Organizer, written for women who plan on ...
(Date:5/2/2016)... MO (PRWEB) , ... May 02, 2016 , ... ... a division of Permobil, recently completed two groundbreaking studies that determined that the ... mattresses – are critical in the prevention of pressure injuries, which are now ...
(Date:5/2/2016)... ... May 02, 2016 , ... Atlantic Information Services, Inc. (AIS) ... B Payment Model Could Transform the Pharma Landscape .” CMS recently proposed a test ... spend on provider-administered drugs while preserving care provided to beneficiaries. The webinar will review ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... FREMONT, Calif. , April 28, 2016 ... Enterprise Validation Lifecycle Management Solutions (VLMS) today ... products and services for sufferers of chronic ... management System to manage their corporate validation ... been seeking a software solution to manage ...
(Date:4/27/2016)... Mass., April 27, 2016  Hologic, Inc. (Nasdaq: ... financial results for the fiscal second quarter ended ... (EPS) of $0.24 increased 41.2%, and non-GAAP diluted ... million increased 5.8% on a reported basis, and ... "We posted another good quarter, highlighted by ...
(Date:4/27/2016)... --   , Total Sales ... Sales  Clinical sales grow 16% year-over-year  , ... OTCQX: MKEAY) inventor of Cellvizio®, the multidisciplinary confocal laser ... quarter ended March 31, 2016 and provided an update ... strategy. First Quarter 2016 Revenue Results by ...
Breaking Medicine Technology:
Cached News: