HOME >> MEDICINE >> NEWS
Disulfiram and cognitive behavioral therapy appear effective for treating cocaine dependence

CHICAGO Disulfiram (a drug used to help selected patients with alcohol disorders remain sober) and cognitive behavioral therapy appear effective in reducing cocaine use, especially among cocaine users who are not dependent on alcohol, according to an article in the March issue of The Archives of General Psychiatry, one of the JAMA/Archives journals.

Patients taking disulfiram who ingest even small amounts of alcohol develop a reaction that produces nausea, flushing, vomiting, and throbbing headache. At times, this reaction can be severe and can lead to critical illness, such as severe respiratory problems, circulatory problems, or even death. According to the article, alcohol is a powerful "cue" for using cocaine, and can impair judgment and lower resistance to cravings for cocaine. Researchers hypothesize that by reducing alcohol use with disulfiram, users might be less likely to abuse cocaine. However, use of disulfiram has not been evaluated in general populations of cocaine users.

Kathleen M. Carroll, Ph.D., from Yale University School of Medicine, New Haven, Conn., and colleagues randomly assigned 121 cocaine-dependent adults (average age, 34.6 years) to receive either disulfiram or placebo over a 12-week period. Participants were also randomized to participate in either cognitive behavioral therapy (CBT) or interpersonal psychotherapy (IPT, a less structured form of behavioral therapy).

"Participants assigned to disulfiram reduced their cocaine use significantly more than those assigned to placebo, and those assigned to CBT reduced their cocaine use significantly more than those assigned to IPT," the authors found. The benefits of disulfiram and CBT were most pronounced in participants who were not alcohol-dependent and who did not drink during the study.

The authors write, "This is the first placebo-controlled trial, to our knowledge, to demonstrate that disulfiram therapy is effective in nonalcoholic cocaine-dependent o
'"/>

Contact: Jacqueline Weaver
203-432-8555
JAMA and Archives Journals
1-Mar-2004


Page: 1 2

Related medicine news :

1. Boston University team finds link between high cholesterol and better cognitive performance
2. Binge drinking can impair both mood and cognitive performance
3. Nonhuman primate males more susceptible to age-related cognitive decline than females
4. Smoking causes cognitive impairment in adolescents
5. Maintaining physical activity linked to less cognitive decline in older men
6. Metabolic syndrome associated with cognitive decline in elderly persons
7. Study reveals link between cardiovascular risk and cognitive decline
8. Yale to study marijuana, ecstasy and teen cognitive deficits
9. Elderly experience long-term cognitive decline after surgery
10. High blood pressure related decline in cognitive function affects adults young and old
11. Trials launched to test treatment of cognitive dysfunction in schizophrenia

Post Your Comments:
(Date:4/27/2015)... 27, 2015 The Doctors on Liens ... clients of personal injury attorneys with the best doctors working ... seen steady growth throughout their history and that trend continues ... and his team in the Tujunga / Sunland ... and massage therapist, patients can find comprehensive care and detailed ...
(Date:4/27/2015)... Sitting or standing for long periods of time can ... those whose occupation requires them to be sitting while they ... to be on their feet for most of the day, ... severe and longer lasting. These people suffer from a condition ... Northeast Houston Vein Center is offering tips on how to ...
(Date:4/27/2015)... Data Integrity Problems on the Rise: , ... Partners/Suppliers, **FDAnews Webinar**, May 19, 2015 — 1:30 p.m. ... integrity issues have become a common and ever increasing ... issues within manufacturing operations or partner networks can be ... remediating them can be even more difficult. , ...
(Date:4/27/2015)... 2015 Douglas Fitzpatrick not only ... feel secure, but also helps secure homes for animals. On ... will be manning a booth at the 2015 Fetch A ... E. 17th Ave., Columbus, Ohio. , “I am very ... feature hundreds of adoptable pets from more than forty different ...
(Date:4/27/2015)... April 27, 2015 A' Design Award ... project SMRT IMAGE Lumica by Boombang Inc Design Team ... A' Design Award in Scientific Instruments, Medical Devices and ... on SMRT IMAGE Lumica, Boombang Inc Design Team, the ... IMAGE Lumica explained “SMRT Image Lumica is a two-way ...
Breaking Medicine News(10 mins):Health News:Prominent Doctors with Distinguished Backgrounds Join Doctors on Liens in Tujunga 2Health News:Northeast Houston Vein Center Offers Tips on How to Treat Achy Legs 2Health News:Northeast Houston Vein Center Offers Tips on How to Treat Achy Legs 3Health News:FDAnews Announces — Data Integrity Problems on the Rise: Confronting Data Integrity Issues Within Your Operations or Your Partners/Suppliers Webinar, May 19, 2015 2Health News:FDAnews Announces — Data Integrity Problems on the Rise: Confronting Data Integrity Issues Within Your Operations or Your Partners/Suppliers Webinar, May 19, 2015 3Health News:FDAnews Announces — Data Integrity Problems on the Rise: Confronting Data Integrity Issues Within Your Operations or Your Partners/Suppliers Webinar, May 19, 2015 4Health News:Farmers Insurance Agent Douglas Fitzpatrick Ensures Pets Find Homes 2Health News:Boombang Inc Design Team wins Platinum in A' Medical Product Design Awards 2
(Date:4/27/2015)... , April 27, 2015 Numerous Zofran ... courts around the U.S. have highlighted serious concerns surrounding ... LLP reports. According to the U.S. Centers for ... currently on the market have enough information to determine ... of 10 expectant mothers in the U.S. take at ...
(Date:4/27/2015)... and WASHINGTON , April ... Pharmacy (NASP) and SmartBrief recently partnered to deliver a ... snapshot of the top news in the industry. The ... pharmaceutical and biotechnology manufacturers, GPOs, distributors and other specialty ... will launch on April 27, 2015. "We ...
(Date:4/27/2015)... 2015  Together with its parent partners and the ... an initiative of Morris County Prevention is Key (MCPIK), ... first-of-its-kind community effort to address the heroin/opiate crisis in ... Volunteer Parent Coaches from the ... Denise Mariano , National Council on Alcoholism and ...
Breaking Medicine Technology:Growing Zofran Birth Defects Litigation Highlights Concerns Surrounding Use of Prescription Medications During Pregnancy, According to Bernstein Liebhard LLP 2Growing Zofran Birth Defects Litigation Highlights Concerns Surrounding Use of Prescription Medications During Pregnancy, According to Bernstein Liebhard LLP 3NASP and SmartBrief Partner on Specialty Pharmacy SmartBrief 2Partnership for Drug-Free Kids Brings Life-Saving Kits and Training to New Jersey Families 2Partnership for Drug-Free Kids Brings Life-Saving Kits and Training to New Jersey Families 3
Cached News: