HOME >> MEDICINE >> NEWS
Docetaxel versus paclitaxel in breast cancer Results of worlds first head to head trial

Copenhagen, Denmark: Eagerly awaited results from the world's first head to head trial between the anti-cancer drugs docetaxel (Taxotere) and paclitaxel (Taxol)[1] have shown that there was a better overall response rate and longer overall survival among breast cancer patients given docetaxel although docetaxel was associated with more severe side effects.

The new results were presented for the first time today (Wednesday 24 September) at ECCO 12 The European Cancer Conference taking place in Copenhagen.

Four hundred and forty nine women with advanced incurable breast cancer who had received previous treatment with an anthracycline-based chemotherapy were randomised into the Phase III trial from multiple centres across the USA between 1994 and 20012. Half were treated with paclitaxel and half were treated with docetaxel.

The trial's principal investigator, Professor Peter Ravdin, associate professor in the Department of Medicine at the University of Texas Health Science Center in San Antonio, told a news briefing that the women treated with docetaxel survived for a median 15.4 months compared with a median 12.7 months for the women who received paclitaxel.

There was an overall response rate of nearly a third among the docetaxel patients compared with a quarter for the paclitaxel patients. The median time before the breast cancer progressed (TTP) was 5.7 months for the docetaxel patients and 3.6 months for the paclitaxel patients. The results for overall survival and for TTP were statistically significantly superior for docetaxel and the overall response rate in favour of docetaxel approached statistical significance.

However, the women who received docetaxel did experience more severe side effects (grade 3/4 toxicities) with higher incidences of neutropenia (reduction in infection-fighting white blood cells), asthenia (loss of strength), infection, oedema (abnormal accumulation of fluid), mouth ulcers and neuromotor and n
'"/>

Contact: Margaret Willson
m.willson@mwcommunications.org.uk
45-3252-4163
Federation of European Cancer Societies
24-Sep-2003


Page: 1 2

Related medicine news :

1. Good intentions versus bad habits: Why the old ways win out
2. Normal aging versus Alzheimers disease and the potential for prevention
3. Regulatory T cells keep graft-versus-host disease in check
4. Study evaluates Abacavir, Lamivudine and Efavirenz versus Zidovudine, Lamivudine and Efavirenz
5. U-M study finds new target in war against graft-versus-host disease
6. Weekly Taxol (paclitaxel) plus Paraplatin (carboplatin) is safe and effective in patients with advanced lung cancer
7. International breast cancer prevention study launches in the United States and Canada
8. Unexpected benefit seen in treating HER-2 breast cancer with new preoperative drug combo
9. Risk of cardiac death after radiotherapy for breast cancer has declined, study finds
10. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
11. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/23/2017)... ... July 23, 2017 , ... ... ™(iaedp), the leading provider of education and training standards for healthcare treatment ... competency for Traditional Certification: the iaedp™ Core Curriculum. , Presented as either ...
(Date:7/23/2017)... Rosa, CA (PRWEB) , ... July 23, 2017 , ... ... of Medicine in St. Louis, and led by the Minneapolis Veterans Administration Health Care ... early stages of the disease offers very few benefits. , In the cases ...
(Date:7/23/2017)... Santa Rosa, CA (PRWEB) , ... July 23, 2017 , ... ... a study indicating women who underwent brief bursts of high-intensity, weight-bearing activity equivalent to ... better bone health. , “As an orthopaedic surgeon who specializes in total spine care, ...
(Date:7/23/2017)... ONTARIO, CANADA (PRWEB) , ... July 23, 2017 ... ... effects of single sport specialization is critical, say researchers presenting their work today ... in Toronto, Canada. , “Our study is the first one to prospectively ...
(Date:7/23/2017)... ... July 23, 2017 , ... Specializing in one sport early in ... college scholarship or even go on to the pros. However, researchers presenting their work ... Canada today say “not so fast.” , “Our study, which is the largest ...
Breaking Medicine News(10 mins):
(Date:7/21/2017)... and EDMONTON, Alberta , July ... and the University of Alberta in ... in Nature,s partner journal, Schizophrenia 1 , demonstrating ... instances of schizophrenia with 74% accuracy. This retrospective ... of specific symptoms in schizophrenia patients with significant ...
(Date:7/21/2017)... RESEARCH TRIANGLE PARK, N.C. , July 21, ... UTHR ) announced today that it will report its ... on Thursday, July 27, 2017. ... Thursday, July 27, 2017, at 9:00 a.m. Eastern Time.  ... callers dialing 1-970-315-0533.  A rebroadcast of the teleconference will ...
(Date:7/21/2017)...  Endo International plc (NASDAQ: ENDP ) ... its manufacturing network, the Company will be ceasing operations ... Huntsville, Alabama . The closure of the ... 12 to 18 months. The Huntsville ... commoditized products and these restructuring actions are intended to ...
Breaking Medicine Technology:
Cached News: