HOME >> MEDICINE >> NEWS
Docetaxel versus paclitaxel in breast cancer Results of worlds first head to head trial

Copenhagen, Denmark: Eagerly awaited results from the world's first head to head trial between the anti-cancer drugs docetaxel (Taxotere) and paclitaxel (Taxol)[1] have shown that there was a better overall response rate and longer overall survival among breast cancer patients given docetaxel although docetaxel was associated with more severe side effects.

The new results were presented for the first time today (Wednesday 24 September) at ECCO 12 The European Cancer Conference taking place in Copenhagen.

Four hundred and forty nine women with advanced incurable breast cancer who had received previous treatment with an anthracycline-based chemotherapy were randomised into the Phase III trial from multiple centres across the USA between 1994 and 20012. Half were treated with paclitaxel and half were treated with docetaxel.

The trial's principal investigator, Professor Peter Ravdin, associate professor in the Department of Medicine at the University of Texas Health Science Center in San Antonio, told a news briefing that the women treated with docetaxel survived for a median 15.4 months compared with a median 12.7 months for the women who received paclitaxel.

There was an overall response rate of nearly a third among the docetaxel patients compared with a quarter for the paclitaxel patients. The median time before the breast cancer progressed (TTP) was 5.7 months for the docetaxel patients and 3.6 months for the paclitaxel patients. The results for overall survival and for TTP were statistically significantly superior for docetaxel and the overall response rate in favour of docetaxel approached statistical significance.

However, the women who received docetaxel did experience more severe side effects (grade 3/4 toxicities) with higher incidences of neutropenia (reduction in infection-fighting white blood cells), asthenia (loss of strength), infection, oedema (abnormal accumulation of fluid), mouth ulcers and neuromotor and n
'"/>

Contact: Margaret Willson
m.willson@mwcommunications.org.uk
45-3252-4163
Federation of European Cancer Societies
24-Sep-2003


Page: 1 2

Related medicine news :

1. Good intentions versus bad habits: Why the old ways win out
2. Normal aging versus Alzheimers disease and the potential for prevention
3. Regulatory T cells keep graft-versus-host disease in check
4. Study evaluates Abacavir, Lamivudine and Efavirenz versus Zidovudine, Lamivudine and Efavirenz
5. U-M study finds new target in war against graft-versus-host disease
6. Weekly Taxol (paclitaxel) plus Paraplatin (carboplatin) is safe and effective in patients with advanced lung cancer
7. International breast cancer prevention study launches in the United States and Canada
8. Unexpected benefit seen in treating HER-2 breast cancer with new preoperative drug combo
9. Risk of cardiac death after radiotherapy for breast cancer has declined, study finds
10. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
11. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women

Post Your Comments:
(Date:11/26/2014)... (PRWEB) November 27, 2014 Recently, ... women’s special occasion dresses, has unveiled its 2014 Cyber ... on these new dresses, up to 90 percent off. ... to Dec. 3. Free delivery is provided for orders ... of women’s dresses, shoes, handbags and other fashion accessories. ...
(Date:11/26/2014)... Sweetdressy.com, the well-known wedding dress manufacturer for ... cheap prom dresses for ladies worldwide. Meanwhile, these graceful ... from Sweetdressy.com are very popular in the world and ... Sweetdressy.com now. , Sweetdressy.com believes that a company ... best items and best services. The spirit of the ...
(Date:11/26/2014)... a well-known wedding dress manufacturer and retailer, has recently ... . Included in the new range are hundreds of ... charming outfits are offered at deeply discounted prices, up ... all of the sweet 16 cocktail gowns are made ... all of them are set according to the latest ...
(Date:11/26/2014)... Norwalk Hospital is pleased to ... by the American Nurses Credentialing Center (ANCC). , ... of work environments where nurses can flourish. The ... Norwalk Hospital and identifies it as one of ... an organizations’ commitment to nurses and their contributions ...
(Date:11/26/2014)... WEDNESDAY, Nov. 26, 2014 (HealthDay News) -- Deaf teens have ... detected at an early age, a new study suggests. ... who were diagnosed with permanent hearing loss through an infant ... the children at age 8 found that those who were ... better language and reading skills than deaf children who weren,t ...
Breaking Medicine News(10 mins):Health News:DressVe.com: Best 2014 Special Monday Sales Online 2Health News:Cheap Prom Dresses For Ladies Introduced At SweetDressy.com 2Health News:iFitDress.com: Trendy Sweet 16 Cocktail Dresses Unveiled 2Health News:Norwalk Hospital Announces American Nurses Credentialing Center PATHWAY TO EXCELLENCE® DESIGNATION 2Health News:Norwalk Hospital Announces American Nurses Credentialing Center PATHWAY TO EXCELLENCE® DESIGNATION 3Health News:Spotting Hearing Problems in Infancy May Boost Reading Skills in Deaf Teens 2
(Date:11/26/2014)... , Nov. 25, 2014  Medtronic,s ... has been widely discussed in the media ... also creating a stronger leading player in one ... Kalorama Information.  The healthcare market research firm said ... will feature a diverse set of solutions spanning ...
(Date:11/26/2014)... Heska Corporation (NASDAQ: HSKA ) - ( ... advanced veterinary diagnostic and other specialty veterinary products , announced ... The Benchmark Company, LLC,s Micro Cap Discovery Conference on Thursday, ... The Palmer House Hilton, 17 E. Monroe Street, ... Please email hska@haydenir.com or contact your Benchmark representative ...
(Date:11/26/2014)... 25, 2014  Array BioPharma Inc. (Nasdaq: ... its Chief Executive Officer, Ron Squarer ... conferences.  The public is welcome to participate ... Array BioPharma website:  www.arraybiopharma.com .Event: Piper Jaffray ...  Eastern Time Location: Palace Hotel, New York ...
Breaking Medicine Technology:Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 2Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 3Heska to Attend Benchmark Micro Cap Discovery Conference 2
Cached News: