HOME >> MEDICINE >> NEWS
Docetaxel versus paclitaxel in breast cancer Results of worlds first head to head trial

Copenhagen, Denmark: Eagerly awaited results from the world's first head to head trial between the anti-cancer drugs docetaxel (Taxotere) and paclitaxel (Taxol)[1] have shown that there was a better overall response rate and longer overall survival among breast cancer patients given docetaxel although docetaxel was associated with more severe side effects.

The new results were presented for the first time today (Wednesday 24 September) at ECCO 12 The European Cancer Conference taking place in Copenhagen.

Four hundred and forty nine women with advanced incurable breast cancer who had received previous treatment with an anthracycline-based chemotherapy were randomised into the Phase III trial from multiple centres across the USA between 1994 and 20012. Half were treated with paclitaxel and half were treated with docetaxel.

The trial's principal investigator, Professor Peter Ravdin, associate professor in the Department of Medicine at the University of Texas Health Science Center in San Antonio, told a news briefing that the women treated with docetaxel survived for a median 15.4 months compared with a median 12.7 months for the women who received paclitaxel.

There was an overall response rate of nearly a third among the docetaxel patients compared with a quarter for the paclitaxel patients. The median time before the breast cancer progressed (TTP) was 5.7 months for the docetaxel patients and 3.6 months for the paclitaxel patients. The results for overall survival and for TTP were statistically significantly superior for docetaxel and the overall response rate in favour of docetaxel approached statistical significance.

However, the women who received docetaxel did experience more severe side effects (grade 3/4 toxicities) with higher incidences of neutropenia (reduction in infection-fighting white blood cells), asthenia (loss of strength), infection, oedema (abnormal accumulation of fluid), mouth ulcers and neuromotor and n
'"/>

Contact: Margaret Willson
m.willson@mwcommunications.org.uk
45-3252-4163
Federation of European Cancer Societies
24-Sep-2003


Page: 1 2

Related medicine news :

1. Good intentions versus bad habits: Why the old ways win out
2. Normal aging versus Alzheimers disease and the potential for prevention
3. Regulatory T cells keep graft-versus-host disease in check
4. Study evaluates Abacavir, Lamivudine and Efavirenz versus Zidovudine, Lamivudine and Efavirenz
5. U-M study finds new target in war against graft-versus-host disease
6. Weekly Taxol (paclitaxel) plus Paraplatin (carboplatin) is safe and effective in patients with advanced lung cancer
7. International breast cancer prevention study launches in the United States and Canada
8. Unexpected benefit seen in treating HER-2 breast cancer with new preoperative drug combo
9. Risk of cardiac death after radiotherapy for breast cancer has declined, study finds
10. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
11. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women

Post Your Comments:
(Date:7/6/2015)... ... July 06, 2015 , ... Dr. Lawrence Green is now offering the newly ... is a non-surgical method to dissolve fat cells and is the first of ... deposits under the chin, commonly known as a double chin. Dr. Green participated in ...
(Date:7/6/2015)... , ... July 06, 2015 , ... ... Jeffrey R. Carlson finished his 100th case using SpineFrontier’s® PedFuse® REmind® Screws. The ... Hospital in Newport News, VA. The procedure was an L5-S1 posterior lumbar interbody ...
(Date:7/6/2015)... ... 06, 2015 , ... Thanks to donations and a generous grant from the ... Memory Certification for hospice patients and adult day center participants. , The Music & ... but also to their families and volunteers. Music & Memory is a non-profit organization ...
(Date:7/5/2015)... ... July 06, 2015 , ... Security ... excited to announce the next generation of PrimeStar Individual Dental Insurance. Beginning now, ... include two network options—Maximum Allowable Charge (MAC) and usual, customary and reasonable (UCR). ...
(Date:7/5/2015)... ... July 05, 2015 , ... Women's Excellence in Wellness, powered by ... These classes are geared towards families that want their children to stay active as ... The fitness class will take place TUESDAYS at 4:30pm. Questions? Call 248-601-6683. Women’s ...
Breaking Medicine News(10 mins):Health News:Rockville, MD Practice Now Offering New FDA-Approved Non-Surgical Double Chin Treatment 2Health News:100th Outpatient Less Exposure Surgery Procedure Completed by Industry Leading Surgeon Dr. Jeffrey Carlson 2Health News:100th Outpatient Less Exposure Surgery Procedure Completed by Industry Leading Surgeon Dr. Jeffrey Carlson 3Health News:Music & Memory Program Brings Joy and Excitement to Hospice Patients 2Health News:Music & Memory Program Brings Joy and Excitement to Hospice Patients 3Health News:Music & Memory Program Brings Joy and Excitement to Hospice Patients 4Health News:Security Life Insurance Company of America Launches the Next Generation of PrimeStar Individual Dental Insurance Plans 2
(Date:7/3/2015)... A global continuing medical education provider is ... in Central and South-East Asia ... dedicated to these diseases.      (Logo: http://photos.prnewswire.com/prnh/20150630/227090) ... Manage Hypertension Online and Manage Thyroid Online ... - combine the world,s top expertise with dynamic ...
(Date:7/3/2015)... , July 3, 2015  Obsidian HDS, the developer ... online service for the management of data on pharmaceutical ... that PharmaShine now includes the 2014 Open Payments General ... Services on June 30. The data disclosed on Open ... between industry and providers totaling $6.49 billion and is ...
(Date:7/2/2015)... , July 2, 2015 /PRNewswire/ - ESSA Pharma Inc. ... common shares have been approved for listing and trading on ... ESSA will begin trading on NASDAQ on July 9, ... Venture Exchange under the symbol "EPI". As a ... NASDAQ, each of the Company,s outstanding special warrants issued on ...
Breaking Medicine Technology:Combating Three Major Chronic Diseases in Central and South-East Asia With Medical Education 2New Open Payments (Sunshine Act) Data Now Searchable on PharmaShine 2ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 2ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 3ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 4
Cached News: