HOME >> MEDICINE >> NEWS
Dopamine may play role in cue-induced craving distinct from its role regulating reward effects

NIDA-supported researchers from Brookhaven National Laboratory and the State University of New York at Stony Brook have found evidence in humans that dopamine plays a role in the conditioned cue response to food. Cuesseeing, smelling, and tasting something enjoyableincrease the desire for the reward without necessarily enhancing the pleasure of the reward itself.

Positron emission tomography (PET) was used to measure changes in dopamine in the brains of 10 healthy adults (eight men and two women) during food and neutral stimulations. Food stimulation consisted of the participants viewing, smelling, and tasting their favorite foods but not actually eating the foods. For neutral stimulation, participants described their family genealogy in detail. Prior to and during food stimulation, participants were instructed to rate their feelings of "hunger," "desire for food," "alertness," "stimulation," and "talkativeness" on a scale of 1 to 10. Participants had fasted 16-20 hours before PET scans were conducted.

Food stimulation caused an increase in dopamine in the dorsal striatum but not in the ventral striatum, where the nucleus accumbens is located. This suggests that dopamine may be involved in food motivation that is distinct from its role in regulating food's reward effects through the nucleus accumbens. Previous research has linked increases in dopamine in the nucleus accumbens, the reward center of the brain, with addiction.

WHAT IT MEANS: The finding that dopamine may play a role in cue-induced effects could have important implications in drug addiction research. Many individuals addicted to drugs, especially cocaine and nicotine, are susceptible to cue-induced cravings. A better understanding of the biological basis of cue-related behaviors may provide better insights in the development of more effective behavioral and pharmacological treatments for drug addiction.


'"/>

Contact: Blair Gately
bgately@nida.nih.gov
301-443-6245
NIH/National Institute on Drug Abuse
28-May-2002


Page: 1

Related medicine news :

1. Dopamine key to learning likes and dislikes, says Colorado U. team
2. Its a gamble: Dopamine levels tied to uncertainty of rewards
3. New Findings On Dopamine Receptor Biology: Implications For Mental Illness
4. Breakthrough? Study Finds Dopamine Cannot Be Source Of Pleasure In Brain
5. Brain regions activated by food craving overlap with areas implicated in drug craving
6. Single cocaine exposure boosts both drug craving and avoidance
7. Comfort-food cravings may be bodys attempt to put brake on chronic stress
8. Compounds also present in alcoholic beverages may explain chocolate cravings
9. Drug that curbs nicotine craving may do same for cocaine
10. Patients recovering from depression with talk therapy show a distinct pattern of brain changes
11. Late-onset schizophrenia found to be distinct condition

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... recover from injury. Recently, he has implemented orthobiologic procedures as a method for ... is one of the first doctors to perform the treatment. Orthobiologics are substances ...
(Date:6/24/2016)... ... 24, 2016 , ... Those who have experienced traumatic events may suffer from ... avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid this ... coping following a traumatic event. , Trauma sufferers tend to feel a range of ...
(Date:6/24/2016)... ... 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida ... their peers for this recognition are considered among the top 2 percent of lawyers ... as members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark ...
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing ... which patients and their families pay tribute to a genetic counselor by nominating him ... Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Any dentist who has made ... the current process. Many of them do not even offer ... difficulties and high laboratory costs involved. And those who ARE ... at such a high cost that the majority of today,s ... Dr. Parsa Zadeh , founder of Dental Evolutions Inc. ...
(Date:6/23/2016)... a startling report released today, National Safety Council research ... proven plan to eliminate prescription opioid overdoses. Prescription Nation ... tackling the worst drug crisis in recorded U.S. history, assigned a ... , New Mexico , Tennessee ... failing states, three – Michigan , ...
(Date:6/23/2016)... 2016 Research and Markets has announced ... Analysis 2016 - Forecast to 2022" report to their ... contains up to date financial data derived from varied research ... trends with potential impact on the market during the next ... which comprises of sub markets, regional and country level analysis. ...
Breaking Medicine Technology:
Cached News: