Doris Duke Charitable Foundation selects Emory HIV/AIDS research team for innovation award

ce and where the electrical supply and refrigeration may be intermittent. We want to develop tests that can be used in resource-poor countries so they can also conduct high-quality monitoring of antiretroviral therapy."

"All of the ongoing efforts to make antiretroviral therapy available in developing countries will be compromised unless effective clinical monitoring tools to determine who needs treatment most and how well someone is responding to treatment are made available in these countries," says Mark Feinberg, MD, PhD, Emory professor of medicine and principal investigator of the Emory project. "At present, HIV therapy in developed countries can be highly effective when it is overseen by knowledgeable clinicians, with the support of state-of-the art clinical monitoring labs. Indeed, many lives are being saved as a result of therapeutic advances. However, both the antiretroviral drugs and the clinical monitoring tools are very expensive and complex to use. Further, the technology needed for contemporary clinical monitoring tools involves complex, expensive equipment that requires near-constant up-keep, and thus will be difficult or impossible to sustain in resource-poor countries. It is imperative that simpler and cheaper, yet reliable tests be developed to enable HIV-infected individuals living in developing countries to derive long-term benefit from the increased availability of antiretroviral therapies."

During the first year of the two-year project, the Emory investigators will work to develop the reconfigured technologies; then, during the second year, they will travel to Ethiopia to field test the new tools to determine their feasibility and effectiveness in the Ethiopian population and in HIV subtype C, the predominant HIV strain in Ethiopia. Subtype B is the predominant strain in the United States.

In addition to Dr. Priddy and Dr. Feinberg, the Emory team includes Angela Caliendo, MD, PhD and Sylvija Staprans, PhD.

If the pil

Contact: Holly Korschun
Emory University Health Sciences Center

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