Drug Prevents Hearing Loss Caused By Brain Tumor Therapy

New Study Offers Hope To Cancer Patients

PORTLAND, Ore., July 7, 1998 -- Reporting in the July issue of the Journal of Pharmacology and Experimental Therapeutics, researchers with the Portland U.S. Department of Veterans Affairs Medical Center and Oregon Health Sciences University have found that they can prevent or sharply reduce hearing loss caused by one of the most effective therapies for brain tumors.

The VA/OHSU team found that treatment with sodium thiosulfate (STS) significantly reduced hearing loss in 29 brain tumor patients receiving the chemotherapy agent carboplatin delivered by opening the blood-brain barrier.

"These findings are very encouraging," said study leader Edward A. Neuwelt, M.D., a neurosurgeon and professor of neurology and neurosurgery at the Portland VA Medical Center and OHSU. He also directs the Blood-Brain Barrier Program located at both the VA and OHSU.

"Not only did we see fewer patients suffer severe hearing loss, but patients who did experience some hearing loss were able to undergo more courses of carboplatin treatment before any loss occurred."

Before the STS trials began, 15 (79 percent) of 19 similar patients suffered profound hearing loss caused by carboplatin treatment. These patients had an average hearing loss of 20.8 decibels after one treatment with carboplatin, while the STS-treated patients lost only 3.7 decibels.

The Portland researchers previously had paved the way for brain tumor treatment with carboplatin and similar agents by pioneering methods to open the "blood-brain barrier" in order to enhance drug delivery (Neurosurgery, May 1998). This natural barrier normally serves as a wall between the blood and brain, helping protect brain tissue.However, it also prevents large-molecule drugs such as carboplatin from reaching a tumor inside the brain.

Using a sugar solution to temporarily shrink the barrier cell

Contact: Henry Sessions or Marlys Pierson
(503) 494-8231
Oregon Health & Science University

Page: 1 2 3

Related medicine news :

1. New Chest Pain Evaluation Method Saves Lives, Prevents Costly HospitalizationFor Some Patients
2. Physicians Study Whether "Super-Aspirin" Prevents Alzheimers
3. Treatment Of Irregular Heartbeat Saves Money And Prevents Stroke In Older People
4. New Drug Prevents Breast Cancer In Postmenopausal Women, UCSF Researchers Report
5. Compound In Meat Prevents Diabetes, Study Suggests
6. Hearing aid signal not clear? Then switch frequency to FM, finds UCI study
7. Hearing problems may be programmed at birth
8. Hearing aid research gets federal boost
9. Hearing infants show preference for sign language over pantomime
10. New Research Points The Way To Restoring Noise-Induced Hearing Loss In Mammals, Including Humans
11. Can We Prevent Hearing Loss In Elderly Women?

Post Your Comments:

(Date:9/2/2020)... ... 02, 2020 , ... RAM Technologies, Inc., the perennial leader ... Special Needs plans, is proud to support the 2020 National Conferences on Medicare, ... supporting the event as a sponsor and exhibitor and will be showcasing their ...
(Date:9/1/2020)... (PRWEB) , ... September 01, 2020 , ... As fall ... side”, the Cohn Health Institute has taken this time to expand and ... of its 30th Anniversary, the Cohn Health Institute will be relaunching its brand new ...
(Date:8/31/2020)... ... ... found out your dear friend has cancer? , It’s hard to hear your doctor say ... diagnosis. Once the shock wears off, the questions and fears can be overwhelming. , How ... to help? Words are failing me. I’m scared. I want to DO something. , We’ve ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... ... of innovative higher-learning opportunities through high-quality, career-relevant, and affordable online education – is ... Psychology . , Among the first of its kind in the nation, ...
(Date:8/31/2020)... ... ... In an effort to give back to the community in which it serves, ... with a special new rate code to benefit children and families at Ronald ... will be applied to any room type, any time, now through the end of ...
Breaking Medicine News(10 mins):
(Date:8/27/2020)... ... , ... Austin Oral Surgery – an oral and maxillofacial surgery practice with ... MD, has joined the practice. An accomplished oral and maxillofacial surgeon, Dr. Szalay’s primary ... to open this fall. The new office is slated for 1601 E. Pflugerville Parkway, ...
(Date:8/27/2020)... ... ... Bridge To A Cure Foundation announces the appointment of Henry Friedman, M.D. ... serves on the Board of Directors at The Preston Robert Tisch Brain Tumor Center ... recognized, Dr. Friedman is a widely published author of more than 500 peer reviewed ...
(Date:8/26/2020)... ... August 26, 2020 , ... ... Laboratory Testing division, expands its technology footprint with the addition of Novocyte ... available. With industry-leading biomarker solutions, complemented with traditional ligand-binding assays and study ...
Breaking Medicine Technology:
Cached News: