Drug cocktail prevents hepatitis B virus from recurring after liver transplant

Aiming to prevent recurrence of the hepatitis B virus (HBV) in post liver-transplant patients, UCLA researchers retrospectively reviewed survival rates of hepatitis B liver-transplantation patients. Their findings show that a combination of two drug therapies improved patient survival rates when compared to existing drug therapies given alone and that long-term treatment dramatically decreases recurrence of the disease.

The results, published in the May issue of the Annals of Surgery, showed the viral prophylaxis therapy or preventive treatment of hepatitis B immune globulin (HBIg) and lamivudine in combination prevents recurrence of HBV infection and lengthens patient survival rates following liver transplantation.

Researchers studied a total of 3,094 liver transplants performed at UCLA Medical Center from 1984 through April 2001. Of those, 191 transplant operations were performed on 166 patients afflicted with HBV cirrhosis. The patients were divided into four treatment groups: no prophylaxis, lamivudine monotherapy, HBIg monotherapy, or a lamivudine and HBIg combination.

When comparing the combination therapy to the monotherapy or no therapy, the HBV-free survival rates were considerably higher for patients who received the combination of HBIg and lamivudine. The one-year and three-year survival rates for the combination therapy were 92 percent and 81 percent, respectively. Survival rates for lamivudine alone were 72 percent and 62 percent. Survival rates for patients who were given HBIg alone were even lower at 45 percent and 36 percent.

Researchers also considered what effect therapy duration might have in HBV recurrence. With short-term HBIg monotherapy, HBV infection recurred in 60 percent of patients after transplant. With long term HBIg monotherapy, which is defined as greater than six months, 40 percent of the patients suffered HBV recurrence. But patients receiving long-term HBIg and lamivudine therapy had a dramatic redu

Contact: Kirsten Holguin
University of California - Los Angeles

Page: 1 2 3

Related medicine news :

1. Screening for osteoporosis prevents hip fractures in older adults
2. Understanding how prostaglandin prevents gut injury during radiation therapy
3. Exercise prevents Parkinsons symptoms in lab model mimicking human form of the disease
4. Study finds once-daily Valcyte prevents serious viral infection after kidney transplant
5. Enzyme prevents lung damage in premature infants
6. Enoxaparin prevents stillbirth in pregnant women with clotting disorder
7. New drug prevents arrhythmias that cause sudden cardiac death
8. Detecting vitamin B12 deficiency prevents anaemia and memory loss
9. Drug prevents diabetes recurrence after islet cell transplantation
10. Gene targeting prevents memory loss in Alzheimers disease model
11. Combined drug therapy prevents progression of prostate enlargement

Post Your Comments:

(Date:9/24/2018)... , ... September 24, 2018 , ... On Sunday, October ... BXP), will host Runyon Up, a stair climb at the new Salesforce Tower in ... their friends, family members and colleagues are expected to take part in this unique ...
(Date:9/24/2018)... TAMPA, Fla. (PRWEB) , ... September 24, 2018 , ... ... – invites all to rise up for a faster cure during Childhood Cancer Awareness ... with a future of uncertainty. Cancer is the number one cause of death by ...
(Date:9/24/2018)... YORK (PRWEB) , ... September 24, 2018 , ... ... 100% homemade and healthy food right to customers’ doorsteps. Its roster of talented ... or businesses once or twice per week. In addition to its standard weekly ...
(Date:9/23/2018)... Mexico (PRWEB) , ... September 22, 2018 , ... Every ... clinics in Mexico. Once thought of decades ago as a poor quality cheap ... of the world’s most advanced computerized dental equipment and an on-site lab. Minutes ...
(Date:9/22/2018)... ... September 21, 2018 , ... From 1991 to 2012, Works of ... Carolina’s programs and clients, all thanks to the generous artists, sponsors, and patrons who ... 1991—about HIV/AIDS, about community response to HIV/AIDS, about the Alliance of AIDS Services - ...
Breaking Medicine News(10 mins):
(Date:9/15/2018)... , ... September 14, 2018 ... ... platform connecting patients and health professionals in Africa, and Axa Insurance Morocco ... strategic shareholders. AXA is DabaDoc’s first institutional shareholder. The capital raise will ...
(Date:9/15/2018)... ... 2018 , ... Today, Mediaplanet announces the launch of this ... within rare diseases research diagnostics and highlights what industry experts and patients see ... , The print component of "Rare Diseases" is distributed in this weekend's edition ...
(Date:9/15/2018)... ... September 14, 2018 , ... "As of Thursday, Sept. ... thanks to Hurricane Florence. I am planning this Women of Influence tour with the ... a suitcase and knowing I have to hold onto my faith through this storm. ...
Breaking Medicine Technology:
Cached News: