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Drug prevents diabetes recurrence after islet cell transplantation

tained healthy glucose levels for just six days. After researchers removed the kidneys, tests showed that insulin-positive beta cells had been retained in the islet cell grafts of the LSF-treated mice.

"We have found that Lisofylline has a unique function in protecting insulin-producing beta cells," said Dr. Zandong Yang, study co-author and assistant professor of research in the division of endocrinology and metabolism at U.Va. "At the cellular level, LSF inhibits a pathway that delivers cytokine damage to beta cells. At the molecular level, we believe LSF enhances the life-span and energy production of beta cells by increasing metabolism in the cellular mitochondria, the engine of a cell."

Yang says U.Va. researchers are hoping to test LSF in human islet cell transplant patients as part of the solution that surrounds the isolated islets. "This would be a great help and protect these cells from dying," he said.


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Contact: Bob Beard
reb8e@virginia.edu
434-982-4490
University of Virginia Health System
20-Jan-2004


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