HOME >> MEDICINE >> NEWS
Drug protects infants with high-risk heart defect from neurologic and cardiac injury after heart surgery

Philadelphia, Pa. A drug used to treat gout in adults also helps protect infants from neurological and cardiac injury after heart surgery for a high-risk birth defect, according to researchers at The Childrens Hospital of Philadelphia. The drug, allopurinol, benefited infants with hypoplastic left heart syndrome (HLHS), in which a severely underdeveloped left ventricle is unable to pump enough blood to the body.

The research team, reporting in the July 2001 issue of the journal Pediatrics, compared 131 infants with HLHS to 187 infants having lower-risk heart defects. "We found that infants with HLHS treated with allopurinol had significantly fewer seizures than those not treated, and significantly fewer cardiac events, such as acute reductions in heart and respiratory rate," said pediatric neurologist Robert R. Clancy, M.D., of Childrens Hospital, the studys lead author. Allopurinol had no corresponding benefit for infants in the study with lower-risk heart conditions.

All 318 infants underwent heart surgery that required cardio-pulmonary bypass and deep hypothermic circulatory arrest (DHCA) in which blood circulation is halted under low-temperature conditions. "This was the first study of neuro-cardiac protection in infants with congenital heart disease who had surgery using DHCA," added Dr. Clancy. Allopurinol caused no significant adverse effects in any of the infants studied.

Allopurinol is commonly used to treat gout in adults. Previous studies in other diseases showed allopurinol could protect the heart and nervous system. Dr. Clancy said the benefits seen in this study may result from the drugs ability to scavenge or inhibit the production of oxygen free radicals, tissue-damaging chemicals produced during circulatory arrest.

Before reconstructive surgery was introduced in the early 1980s, HLHS was invariably fatal in early childhood. Survival rates for HLHS have been improving over the past 20 years, although children wi
'"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
215-590-7332
Children's Hospital of Philadelphia
2-Jul-2001


Page: 1 2

Related medicine news :

1. Red wine protects the heart
2. Component of green tea protects injured livers in mice
3. Substance protects resilient staph bacteria
4. Gene vaccine protects mice against development of Her2/neu breast cancer
5. Blocking molecules protects health of implants
6. New drug protects against the hardening of arteries
7. Good parenting protects against chronic illness says professor of public health
8. Exercising limbs protects brain cells affected by Parkinsons, study in rodents shows
9. Mechanism found that protects aggressive melanoma from angiogenesis inhibitors
10. Chicken pox vaccine saves $$, protects whole population
11. Diet of worms protects against bowel cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... IRVINE, Calif. (PRWEB) , ... August 31, 2020 ... ... providers of business support services to dental groups in the United States, today ... serving the community of Beaumont, CA. , Patients will enjoy convenient hours, ...
(Date:8/31/2020)... ... 31, 2020 , ... Dr. Chang has over 20 years ... other developmental disabilities, as well as supporting staff in caring for patients and ... consultation, and staff development. She joined the company in 2015 as Chief of ...
(Date:8/28/2020)... ... August 28, 2020 , ... WHAT ... help treat patients with respiratory conditions, including COVID-19, while reducing the need for ... but it captures exhaled gas and scrubs it free of carbon dioxide in ...
(Date:8/28/2020)... , ... August 28, 2020 , ... ... in advising Adventist Health on its investment in Synchronous Health, a tech-enabled behavioral ... that combines the strength of human empathy with artificial intelligence (AI) to increase ...
(Date:8/27/2020)... ... August 27, 2020 , ... ... Evolution Labs to provide their students with Suite360:Mental Health and Prevention, a program ... Substance Abuse and Child Trafficking Prevention. , Florida schools and districts must provide ...
Breaking Medicine News(10 mins):
(Date:8/31/2020)... ... 31, 2020 , ... Cloudticity announced today that Network Products ... winner in the 15th Annual 2020 Network PG’s IT World Awards®. , The ... Network Products Guide honoring achievements of world’s best in organizational performance, product and ...
(Date:8/28/2020)... ... August 28, 2020 , ... Dr. Mark Surrey has been in ... serves as a clinical professor in the Department of OBGYN at UCLA’s David Geffen ... & Pacific Coast Reproductive Society and is a Clinical Director of Fellowship Training for ...
(Date:8/27/2020)... ... August 27, 2020 , ... InfoMC, a leading ... completion of their 2020 System and Organizational Controls (SOC) 1® Type 2 and ... MARS-E compliance assessment. These achievements reflect their long-standing commitment to privacy, security, and ...
Breaking Medicine Technology:
Cached News: